SPART_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPART_DROME
• UniProt AC: Q9VN45
• Protein Name: Protein spartin {ECO:0000303|PubMed:23439121}
• Gene Name: spartin {ECO:0000312|FlyBase:FBgn0037265}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 553
• Subcellular Localization: Cell junction, synapse, presynaptic cell membrane . Early endosome . Lipid droplet . Colocalizes with Eps-15 at presynaptic cell membrane.
• Protein Description: During postembryonic development, functions with endocytic adapter Eps-15 in neurons to restrain synaptic growth, by inhibiting BMP signaling, and to control synaptic endocytosis. Required presynaptically for neuromuscular junction (NMJ) neurotransmission. Inhibits neuronal BMP signaling by promoting endocytic internalization and subsequent endosomal trafficking of the BMP receptor wit. In this way, regulates the Fmr1 translational regulator controlling Futsch expression to modulate neuronal microtubule stability, which controls both synaptogenesis and neuronal survival..
• Protein Sequence: MAEEESEFLEAYAGIRTAYKAAMTQVDLAVSHEEQESPGQAIVAYELALRMIEDTFGIPVGLPNKIDTVQAEWNDACALIQKLKSAETELRYRLKVLRSQKQSIDDSAVEATEESRAEMDTKRPPLLAENPSTQYGIANASGAPKTYRELAAGLRELLAVRDAKVLLDELFRAQVKMYRIEASGSVTTISGSSTMSLVMCTVGGKWKYLSGIYFIQCSMPNEGTAGIWLYPLVPSITNCYQTEYGAFIFPDMECQQPGNAFGLMLTKEGQTSRTEDELEDLQQFFLDLLEAVLAGTVVQLKSPTSQRAGLASDTVSGSEQVSRHIVSAADFIASNLVRGAEKTGGFMLRSTPYIISKMTPASMDAQVPSSVQTSVEVAQKVTHAAAGMTGWIAGKVGTASMAVGRYLAPHIQEQGSKLLQKGFGYDTSEANSTMEGAMTIAAGAVEGVSTVFDGLETSAKILGSSLSENSVKIIEHKYGQQTGNLASGTFDTVGNVFVVSQNVNYITPKGIAKKMVKRTGEAVVSDYKRDLRKSESHYINAGSLYPDLRALKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
132	Phosphorylation	PLLAENPSTQYGIAN CCCCCCCCCCCCCCC		21082442
534	Phosphorylation	YKRDLRKSESHYINA HHHHHHHCHHCCCCH		19429919
536	Phosphorylation	RDLRKSESHYINAGS HHHHHCHHCCCCHHC		19429919
538	Phosphorylation	LRKSESHYINAGSLY HHHCHHCCCCHHCCC		19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPART_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPART_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPART_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GAS8_DROME	Gas8	physical	14605208
FUTSC_DROME	futsch	genetic	23439121

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.