SPAG4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPAG4_HUMAN
• UniProt AC: Q9NPE6
• Protein Name: Sperm-associated antigen 4 protein
• Gene Name: SPAG4
• Organism: Homo sapiens (Human).
• Sequence Length: 437
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, flagellum axoneme . Nucleus envelope . Nucleus inner membrane . In spermatids, it is localized in the transient manchette and in the axoneme of elongating spe
• Protein Description: Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail..
• Protein Sequence: MRRSSRPGSASSSRKHTPNFFSENSSMSITSEDSKGLRSAEPGPGEPEGRRARGPSCGEPALSAGVPGGTTWAGSSQQKPAPRSHNWQTACGAATVRGGASEPTGSPVVSEEPLDLLPTLDLRQEMPPPRVFKSFLSLLFQGLSVLLSLAGDVLVSMYREVCSIRFLFTAVSLLSLFLSAFWLGLLYLVSPLENEPKEMLTLSEYHERVRSQGQQLQQLQAELDKLHKEVSTVRAANSERVAKLVFQRLNEDFVRKPDYALSSVGASIDLQKTSHDYADRNTAYFWNRFSFWNYARPPTVILEPHVFPGNCWAFEGDQGQVVIQLPGRVQLSDITLQHPPPSVEHTGGANSAPRDFAVFGLQVYDETEVSLGKFTFDVEKSEIQTFHLQNDPPAAFPKVKIQILSNWGHPRFTCLYRVRAHGVRTSEGAEGSAQGPH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Acetylation	GSASSSRKHTPNFFS CCCCCCCCCCCCCCC	54.50	7467799
35	Acetylation	SITSEDSKGLRSAEP EEECCCCCCCCCCCC	74.43	7467807
228	Ubiquitination	AELDKLHKEVSTVRA HHHHHHHHHHHHHHH	70.96	29967540
243	Ubiquitination	ANSERVAKLVFQRLN HCHHHHHHHHHHHCC	42.18	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPAG4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPAG4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPAG4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ODFP1_HUMAN	ODF1	physical	10373309

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.