SP20H_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SP20H_MOUSE
• UniProt AC: Q7TT00
• Protein Name: Transcription factor SPT20 homolog
• Gene Name: Supt20h
• Organism: Mus musculus (Mouse).
• Sequence Length: 530
• Protein Description: Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy..
• Protein Sequence: MQQAVEQALDCAEYIVESAQQRPPKRKYLSSGRKSIFQKLYDLYVEECEKEPEVKKLRRNVNLLEKLVMQETLSCLVVNLYPGNEGYSLMLRGKNGSDSETIRLPYEEGELLEYLDAEELPPILVDLLEKSQVNIFHCGCVIAEIRDYRQSSNMKSPGYQSRHILLRPTMQTLVCDVHSITSDNHKWTQEDKLLLESQLILATAEPLCLDPSVAVACTANRLLYNRQKMNTRPMKRCWKRYSRSSLNRQQDLSHGPPPPQLRLLDFLQKRKERKAGQHYDLKISKAGNCVDMWKRSPCNLAVPSEVDVEKYAKVEESIKSDDSQPTMWPAHDVKDDYVFECEGGNQYQKTKLTILQSLGDPLYYGKIQPWKADEENDSQMSPSHSSADDHSNWFVIGSKTDAERVVNQYQELVQNEAKCPVKMSHSSSGSAALSPGEEAEQAETSSIQSSVLGKGVKHRPPPIKLPSGSGNSSSGNYFTAQQASSFLKSPTPPPSCKPSLSRKSSVDLSQVSMLSPAALSPASSSQRHES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
172	Phosphorylation	LLRPTMQTLVCDVHS HHCCCCCEEEEEEEC		23567750
246	Phosphorylation	KRYSRSSLNRQQDLS HHHCCHHHHCHHCHH		24719451
296	Phosphorylation	CVDMWKRSPCNLAVP CCCCCCCCCCCCCCC		25266776
378	Phosphorylation	KADEENDSQMSPSHS CCCCCCCCCCCCCCC		21149613
381	Phosphorylation	EENDSQMSPSHSSAD CCCCCCCCCCCCCCC		27087446
383	Phosphorylation	NDSQMSPSHSSADDH CCCCCCCCCCCCCCC		21149613
385	Phosphorylation	SQMSPSHSSADDHSN CCCCCCCCCCCCCCC		21149613
391	Phosphorylation	HSSADDHSNWFVIGS CCCCCCCCCEEEEEC		21183079
398	Phosphorylation	SNWFVIGSKTDAERV CCEEEEECHHHHHHH		23375375
424	Phosphorylation	AKCPVKMSHSSSGSA CCCCCCCCCCCCCCC		28066266
426	Phosphorylation	CPVKMSHSSSGSAAL CCCCCCCCCCCCCCC		28066266
427	Phosphorylation	PVKMSHSSSGSAALS CCCCCCCCCCCCCCC		28066266
428	Phosphorylation	VKMSHSSSGSAALSP CCCCCCCCCCCCCCC		25619855
430	Phosphorylation	MSHSSSGSAALSPGE CCCCCCCCCCCCCCH		28066266
434	Phosphorylation	SSGSAALSPGEEAEQ CCCCCCCCCCHHHHH		25619855
444	Phosphorylation	EEAEQAETSSIQSSV HHHHHHHHHCCHHHH		25619855
489	Phosphorylation	QASSFLKSPTPPPSC HHHHHHCCCCCCCCC		25619855
491	Phosphorylation	SSFLKSPTPPPSCKP HHHHCCCCCCCCCCC		25619855
495	Phosphorylation	KSPTPPPSCKPSLSR CCCCCCCCCCCCCCC		25619855
497	Acetylation	PTPPPSCKPSLSRKS CCCCCCCCCCCCCCC		23806337
501	Phosphorylation	PSCKPSLSRKSSVDL CCCCCCCCCCCCCCH		25619855
504	Phosphorylation	KPSLSRKSSVDLSQV CCCCCCCCCCCHHHH		21082442
505	Phosphorylation	PSLSRKSSVDLSQVS CCCCCCCCCCHHHHH		21082442
506	Phosphorylation	SLSRKSSVDLSQVSM CCCCCCCCCHHHHHH		24719451
509	Phosphorylation	RKSSVDLSQVSMLSP CCCCCCHHHHHHCCH		25619855
512	Phosphorylation	SVDLSQVSMLSPAAL CCCHHHHHHCCHHHC		25619855
515	Phosphorylation	LSQVSMLSPAALSPA HHHHHHCCHHHCCCC		21082442
520	Phosphorylation	MLSPAALSPASSSQR HCCHHHCCCCCCCCC		21082442
523	Phosphorylation	PAALSPASSSQRHES HHHCCCCCCCCCCCC		26745281
530	Phosphorylation	SSSQRHES------- CCCCCCCC-------		28576409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SP20H_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SP20H_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SP20H_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MK14_MOUSE	Mapk14	physical	16751104

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.