dbPTM

SOX12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SOX12_HUMAN
UniProt AC	O15370
Protein Name	Transcription factor SOX-12
Gene Name	SOX12
Organism	Homo sapiens (Human).
Sequence Length	315
Subcellular Localization	Nucleus .
Protein Description	Binds to the sequence 5'-AACAAT-3'..
Protein Sequence	MVQQRGARAKRDGGPPPPGPGPAEEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGGSGGGSRLKPGPQLPGRGGRRAAGGPLGGGAAAPEDDDEDDDEELLEVRLVETPGRELWRMVPAGRAARGQAERAQGPSGEGAAAAAAASPTPSEDEEPEEEEEEAAAAEEGEEETVASGEESLGFLSRLPPGPAGLDCSALDRDPDLQPPSGTSHFEFPDYCTPEVTEMIAGDWRPSSIADLVFTY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Ubiquitination	EAERLRLKHMADYPD HHHHHCHHHHHCCCC	25.54	-
104	Phosphorylation	RLKHMADYPDYKYRP CHHHHHCCCCCCCCC	6.62	22817900
107	Phosphorylation	HMADYPDYKYRPRKK HHHCCCCCCCCCCCC	12.86	22817900
108	Ubiquitination	MADYPDYKYRPRKKS HHCCCCCCCCCCCCC	42.01	-
130	Phosphorylation	RPRPPGGSGGGSRLK CCCCCCCCCCCCCCC	39.93	24732914
134	Phosphorylation	PGGSGGGSRLKPGPQ CCCCCCCCCCCCCCC	37.40	24732914
137	Ubiquitination	SGGGSRLKPGPQLPG CCCCCCCCCCCCCCC	46.98	-
145	Methylation	PGPQLPGRGGRRAAG CCCCCCCCCCCCCCC	42.31	54559557
148	Methylation	QLPGRGGRRAAGGPL CCCCCCCCCCCCCCC	28.08	115383491
181	Phosphorylation	LEVRLVETPGRELWR HHEEEEECCCHHHHH	24.46	29978859
218	Phosphorylation	AAAAAAASPTPSEDE HHHHHHCCCCCCCCC	25.28	25921289
222	Phosphorylation	AAASPTPSEDEEPEE HHCCCCCCCCCCCHH	61.22	25921289

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SOX12_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SOX12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SOX12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SPEE_HUMAN	SRM	physical	21988832

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SOX12_HUMAN

Related Literatures of Post-Translational Modification