SORC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SORC2_HUMAN
• UniProt AC: Q96PQ0
• Protein Name: VPS10 domain-containing receptor SorCS2
• Gene Name: SORCS2
• Organism: Homo sapiens (Human).
• Sequence Length: 1159
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Sequence: MAHRGPSRASKGPGPTARAPSPGAPPPPRSPRSRPLLLLLLLLGACGAAGRSPEPGRLGPHAQLTRVPRSPPAGRAEPGGGEDRQARGTEPGAPGPSPGPAPGPGEDGAPAAGYRRWERAAPLAGVASRAQVSLISTSFVLKGDATHNQAMVHWTGENSSVILILTKYYHADMGKVLESSLWRSSDFGTSYTKLTLQPGVTTVIDNFYICPTNKRKVILVSSSLSDRDQSLFLSADEGATFQKQPIPFFVETLIFHPKEEDKVLAYTKESKLYVSSDLGKKWTLLQERVTKDHVFWSVSGVDADPDLVHVEAQDLGGDFRYVTCAIHNCSEKMLTAPFAGPIDHGSLTVQDDYIFFKATSANQTKYYVSYRRNEFVLMKLPKYALPKDLQIISTDESQVFVAVQEWYQMDTYNLYQSDPRGVRYALVLQDVRSSRQAEESVLIDILEVRGVKGVFLANQKIDGKVMTLITYNKGRDWDYLRPPSMDMNGKPTNCKPPDCHLHLHLRWADNPYVSGTVHTKDTAPGLIMGAGNLGSQLVEYKEEMYITSDCGHTWRQVFEEEHHILYLDHGGVIVAIKDTSIPLKILKFSVDEGLTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFGHISFRSDWELVKVDFRPSFSRQCGEEDYSSWELSNLQGDRCIMGQQRSFRKRKSTSWCIKGRSFTSALTSRVCECRDSDFLCDYGFERSSSSESSTNKCSANFWFNPLSPPDDCALGQTYTSSLGYRKVVSNVCEGGVDMQQSQVQLQCPLTPPRGLQVSIQGEAVAVRPGEDVLFVVRQEQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHRYESPGIYRVSVRAENTAGHDEAVLFVQVNSPLQALYLEVVPVIGLNQEVNLTAVLLPLNPNLTVFYWWIGHSLQPLLSLDNSVTTRFSDTGDVRVTVQAACGNSVLQDSRVLRVLDQFQVMPLQFSKELDAYNPNTPEWREDVGLVVTRLLSKETSVPQELLVTVVKPGLPTLADLYVLLPPPRPTRKRSLSSDKRLAAIQQVLNAQKISFLLRGGVRVLVALRDTGTGAEQLGGGGGYWAVVVLFVIGLFAAGAFILYKFKRKRPGRTVYAQMHNEKEQEMTSPVSHSEDVQGAVQGNHSGVVLSINSREMHSYLVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Acetylation	RGPSRASKGPGPTAR CCCCCCCCCCCCCCC	69.05	19806587
21	O-linked_Glycosylation	GPTARAPSPGAPPPP CCCCCCCCCCCCCCC	34.67	OGP
65	O-linked_Glycosylation	LGPHAQLTRVPRSPP CCCCCCCEECCCCCC	19.96	55833777
133	Phosphorylation	VASRAQVSLISTSFV HCCHHEEEEEEEEEE	14.12	22964224
136	Phosphorylation	RAQVSLISTSFVLKG HHEEEEEEEEEEEEC	24.24	22964224
137	Phosphorylation	AQVSLISTSFVLKGD HEEEEEEEEEEEECC	21.13	22964224
158	N-linked_Glycosylation	MVHWTGENSSVILIL EEEEECCCCEEEEEE	40.71	UniProtKB CARBOHYD
179	Phosphorylation	DMGKVLESSLWRSSD CHHHHHHHHHHCCCC	26.94	23403867
180	Phosphorylation	MGKVLESSLWRSSDF HHHHHHHHHHCCCCC	23.68	23403867
184	Phosphorylation	LESSLWRSSDFGTSY HHHHHHCCCCCCCCC	23.76	-
189	Phosphorylation	WRSSDFGTSYTKLTL HCCCCCCCCCEEEEE	20.67	29083192
190	Phosphorylation	RSSDFGTSYTKLTLQ CCCCCCCCCEEEEEC	31.05	29083192
191	Phosphorylation	SSDFGTSYTKLTLQP CCCCCCCCEEEEECC	14.02	29083192
192	Phosphorylation	SDFGTSYTKLTLQPG CCCCCCCEEEEECCC	21.24	29083192
223	Phosphorylation	KVILVSSSLSDRDQS EEEEEECCCCCCCHH	25.12	-
234	Phosphorylation	RDQSLFLSADEGATF CCHHCEEECCCCCCC	26.75	-
240	Phosphorylation	LSADEGATFQKQPIP EECCCCCCCCCCCCC	37.14	-
267	Phosphorylation	EDKVLAYTKESKLYV HCCEEEEECCCCEEE	23.80	-
276	Phosphorylation	ESKLYVSSDLGKKWT CCCEEECCCCCCCEE	27.15	-
328	N-linked_Glycosylation	YVTCAIHNCSEKMLT EEEEEEECCCCCCEE	25.54	UniProtKB CARBOHYD
362	N-linked_Glycosylation	FFKATSANQTKYYVS EEEECCCCCEEEEEE	50.23	UniProtKB CARBOHYD
407	Phosphorylation	FVAVQEWYQMDTYNL EEEEEEEEECCCCCC	8.00	26074081
411	Phosphorylation	QEWYQMDTYNLYQSD EEEEECCCCCCCCCC	14.68	26074081
412	Phosphorylation	EWYQMDTYNLYQSDP EEEECCCCCCCCCCC	10.02	26074081
415	Phosphorylation	QMDTYNLYQSDPRGV ECCCCCCCCCCCHHC	11.44	26074081
417	Phosphorylation	DTYNLYQSDPRGVRY CCCCCCCCCCHHCEE	35.71	26074081
424	Phosphorylation	SDPRGVRYALVLQDV CCCHHCEEEEEEHHH	11.24	26074081
434	Phosphorylation	VLQDVRSSRQAEESV EEHHHHCCCCCHHHE	20.18	23532336
440	Phosphorylation	SSRQAEESVLIDILE CCCCCHHHEEEEHHH	17.46	23532336
471	Phosphorylation	KVMTLITYNKGRDWD EEEEEEEEECCCCCC	14.10	-
516	Phosphorylation	DNPYVSGTVHTKDTA CCCEECCEEECCCCC	11.12	22210691
519	Phosphorylation	YVSGTVHTKDTAPGL EECCEEECCCCCCCE	26.69	22210691
522	Phosphorylation	GTVHTKDTAPGLIMG CEEECCCCCCCEEEC	35.99	21214269
535	Phosphorylation	MGAGNLGSQLVEYKE ECCCCHHHHHHHEEC	24.41	-
540	Phosphorylation	LGSQLVEYKEEMYIT HHHHHHHEECCEEEE	19.07	21214269
600	N-linked_Glycosylation	GLTWSTHNFTSTSVF CCCEECCCCCCEEEE	41.81	UniProtKB CARBOHYD
726	Phosphorylation	ESSTNKCSANFWFNP CCCCCCCCCCEECCC	28.05	-
828	Phosphorylation	GDGFKAMYVNLTLTG CCCEEEEEEEEEECC	7.34	30576142
830	N-linked_Glycosylation	GFKAMYVNLTLTGEP CEEEEEEEEEECCCC	15.15	UniProtKB CARBOHYD
891	N-linked_Glycosylation	IGLNQEVNLTAVLLP ECCCCCEEEEEEEEE	30.81	UniProtKB CARBOHYD
902	N-linked_Glycosylation	VLLPLNPNLTVFYWW EEEECCCCCEEEEEE	47.47	UniProtKB CARBOHYD
1034	Phosphorylation	TRKRSLSSDKRLAAI CCCCCCCHHHHHHHH	53.06	-
1051	Phosphorylation	VLNAQKISFLLRGGV HHHHHHHHHHHCCCE	19.51	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SORC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SORC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SORC2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SORC2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.