SO4A1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SO4A1_HUMAN
• UniProt AC: Q96BD0
• Protein Name: Solute carrier organic anion transporter family member 4A1
• Gene Name: SLCO4A1
• Organism: Homo sapiens (Human).
• Sequence Length: 722
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate..
• Protein Sequence: MPLHQLGDKPLTFPSPNSAMENGLDHTPPSRRASPGTPLSPGSLRSAAHSPLDTSKQPLCQLWAEKHGARGTHEVRYVSAGQSVACGWWAFAPPCLQVLNTPKGILFFLCAAAFLQGMTVNGFINTVITSLERRYDLHSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLLMGTGSLVFALPHFTAGRYEVELDAGVRTCPANPGAVCADSTSGLSRYQLVFMLGQFLHGVGATPLYTLGVTYLDENVKSSCSPVYIAIFYTAAILGPAAGYLIGGALLNIYTEMGRRTELTTESPLWVGAWWVGFLGSGAAAFFTAVPILGYPRQLPGSQRYAVMRAAEMHQLKDSSRGEASNPDFGKTIRDLPLSIWLLLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFFVNKLRLRGSAVIKFCLFCTVVSLLGILVFSLHCPSVPMAGVTASYGGSLLPEGHLNLTAPCNAACSCQPEHYSPVCGSDGLMYFSLCHAGCPAATETNVDGQKVYRDCSCIPQNLSSGFGHATAGKCTSTCQRKPLLLVFIFVVIFFTFLSSIPALTATLRCVRDPQRSFALGIQWIVVRILGGIPGPIAFGWVIDKACLLWQDQCGQQGSCLVYQNSAMSRYILIMGLLYKVLGVLFFAIACFLYKPLSESSDGLETCLPSQSSAPDSATDSQLQSSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Ubiquitination	PLHQLGDKPLTFPSP CHHHCCCCCCCCCCC	39.88	29967540
12	Phosphorylation	QLGDKPLTFPSPNSA HCCCCCCCCCCCCHH	41.86	23186163
15	Phosphorylation	DKPLTFPSPNSAMEN CCCCCCCCCCHHHHC	32.30	25159151
18	Phosphorylation	LTFPSPNSAMENGLD CCCCCCCHHHHCCCC	32.17	25159151
27	Phosphorylation	MENGLDHTPPSRRAS HHCCCCCCCCCCCCC	36.24	25159151
30	Phosphorylation	GLDHTPPSRRASPGT CCCCCCCCCCCCCCC	35.29	25159151
34	Phosphorylation	TPPSRRASPGTPLSP CCCCCCCCCCCCCCC	23.27	30266825
37	Phosphorylation	SRRASPGTPLSPGSL CCCCCCCCCCCCCCH	25.17	23927012
40	Phosphorylation	ASPGTPLSPGSLRSA CCCCCCCCCCCHHHH	28.55	23927012
43	Phosphorylation	GTPLSPGSLRSAAHS CCCCCCCCHHHHCCC	24.80	25159151
46	Phosphorylation	LSPGSLRSAAHSPLD CCCCCHHHHCCCCCC	34.79	25159151
50	Phosphorylation	SLRSAAHSPLDTSKQ CHHHHCCCCCCCCCC	23.56	28355574
54	Phosphorylation	AAHSPLDTSKQPLCQ HCCCCCCCCCCCHHH	45.57	29396449
55	Phosphorylation	AHSPLDTSKQPLCQL CCCCCCCCCCCHHHH	29.03	30576142
56	Ubiquitination	HSPLDTSKQPLCQLW CCCCCCCCCCHHHHH	59.01	21963094
66	Ubiquitination	LCQLWAEKHGARGTH HHHHHHHHHCCCCEE	39.32	21963094
197	Phosphorylation	PHFTAGRYEVELDAG CCCCCCCEEEEEECC	24.33	-
300	Phosphorylation	MGRRTELTTESPLWV CCCCCCCCCCCCCEE	23.45	22210691
353 (in isoform 3)	Ubiquitination	-	49.33	21906983
353 (in isoform 1)	Ubiquitination	-	49.33	21906983
353 (in isoform 4)	Ubiquitination	-	49.33	21906983
353	Ubiquitination	AAEMHQLKDSSRGEA HHHHHHCCCCCCCCC	49.33	21906983
355	Phosphorylation	EMHQLKDSSRGEASN HHHHCCCCCCCCCCC	21.98	25159151
356	Phosphorylation	MHQLKDSSRGEASNP HHHCCCCCCCCCCCC	55.21	25627689
361	Phosphorylation	DSSRGEASNPDFGKT CCCCCCCCCCCCCCH	44.59	26657352
367 (in isoform 1)	Ubiquitination	-	40.55	21906983
367 (in isoform 3)	Ubiquitination	-	40.55	21906983
367 (in isoform 4)	Ubiquitination	-	40.55	21906983
367	Ubiquitination	ASNPDFGKTIRDLPL CCCCCCCCHHHHCCH	40.55	21963094
394	Phosphorylation	LLCLAGATEATLITG HHHHCCCCHHHHHHC	25.82	-
406	Phosphorylation	ITGMSTFSPKFLESQ HHCCCCCCHHHHHHC	27.54	24719451
499	N-linked_Glycosylation	LLPEGHLNLTAPCNA CCCCCCCCCCCCCCC	29.66	UniProtKB CARBOHYD
557	N-linked_Glycosylation	DCSCIPQNLSSGFGH CCCCCCCCCCCCCCC	36.21	UniProtKB CARBOHYD
569	Ubiquitination	FGHATAGKCTSTCQR CCCCCCCCCCCHHCC	31.69	21963094
666	Phosphorylation	QNSAMSRYILIMGLL CCCHHHHHHHHHHHH	7.86	25072903
674	Phosphorylation	ILIMGLLYKVLGVLF HHHHHHHHHHHHHHH	12.23	25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SO4A1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SO4A1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SO4A1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SO4A1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; THR-37; SER-40;SER-43; SER-46 AND SER-50, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND MASSSPECTROMETRY.
PubMed: 18691976

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40, AND MASSSPECTROMETRY.
PubMed: 18220336

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40, AND MASSSPECTROMETRY.
PubMed: 15302935