SO1C1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SO1C1_RAT
• UniProt AC: Q9EPZ7
• Protein Name: Solute carrier organic anion transporter family member 1C1
• Gene Name: Slco1c1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 716
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus.
• Protein Description: Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency (By similarity). May play a signifiant role in regulating T4 flux into and out of the brain..
• Protein Sequence: MDTSSKENAHLFHKNSAQPAGGPSFKAGYPSTEEARPCCGKLKVFLGALSFVYFAKALTEGYLKSTITQIERRFDIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGFGTMLIAVPQFFMEKYSYEKYERYSPSSNLTPNISPCYLESSSPSPRSIVGKSQNKINDECEVDTSSSMWVYVFLGNLLRGLGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGFLSLLAAVPFWCLPKTLPRSQSREDSGSSSEKSKFITDDPVNYQMAPREESMKIMEMARDFLPSLKSLFRNPVYILYLCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLLFLSLFALGCENSSVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYASACLAGCQSSSRSGKNIIFSNCTCVGFAAPKSGNWSGMMGRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRCIQPQLKSFALGIYTLAVRVLAGIPAPVYFGVLIDTSCLKWGFKKCGSRGSCRLYDSHAFRHIYLGLTTLLGTVSVFLSTAVLLVLKKKYVSKRSSFITAREKIVMSSSVKKETCAARDHGLQPKYWPGKETRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
163	Phosphorylation	PCYLESSSPSPRSIV CCEECCCCCCCHHHC	38.38	22668510
165	Phosphorylation	YLESSSPSPRSIVGK EECCCCCCCHHHCCC	34.59	22668510
313	Phosphorylation	QSREDSGSSSEKSKF HCCCCCCCCCCCCCC	34.34	25403869
314	Phosphorylation	SREDSGSSSEKSKFI CCCCCCCCCCCCCCC	46.14	25403869
319	Ubiquitination	GSSSEKSKFITDDPV CCCCCCCCCCCCCCC	52.43	-
453	N-linked_Glycosylation	LFALGCENSSVAGLT HHHHCCCCCCCCCEE	43.60	-
524	N-linked_Glycosylation	GKNIIFSNCTCVGFA CCCEEEECCEEEEEE	17.86	-
537	N-linked_Glycosylation	FAAPKSGNWSGMMGR EECCCCCCCCHHHCC	36.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SO1C1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SO1C1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SO1C1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SO1C1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.