SNX3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNX3_RAT
• UniProt AC: Q5U211
• Protein Name: Sorting nexin-3
• Gene Name: Snx3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 162
• Subcellular Localization: Early endosome . Cytoplasmic vesicle, phagosome . Colocalizes to clathrin-coated endosomal vesicles morphologically distinct from retromer-decorated non-branched endosomal tubule structures. Colocalizes with EEA1 on nascent phagosomes in dendritic ce
• Protein Description: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC). May act in part as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor Tfrc presuambly by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex. Involved in regulation of neurite outgrowth in primary neurons..
• Protein Sequence: MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAETVADTR ------CCCCHHHHH	22.59	-
22	Phosphorylation	PQNLNDAYGPPSNFL CCCCCCCCCCCCCCE	32.78	22276854
26	Phosphorylation	NDAYGPPSNFLEIDV CCCCCCCCCCEEEEC	43.26	25532521
43	Methylation	PQTVGVGRGRFTTYE CCEEEECCCCCEEEE	30.61	31124813
45	Methylation	TVGVGRGRFTTYEIR EEEECCCCCEEEEEE	25.11	31122787
71	Phosphorylation	ESTVRRRYSDFEWLR CCHHHHHHHCHHHHH	15.69	22108457
72	Phosphorylation	STVRRRYSDFEWLRS CHHHHHHHCHHHHHH	33.73	21738781
95	Ubiquitination	VVPPLPGKAFLRQLP ECCCCCCCHHHHCCC	33.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNX3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNX3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNX3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SNX3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.