SNPH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNPH_HUMAN
• UniProt AC: O15079
• Protein Name: Syntaphilin
• Gene Name: SNPH
• Organism: Homo sapiens (Human).
• Sequence Length: 494
• Subcellular Localization: Membrane ; Single-pass membrane protein . Cell junction, synapse, synaptosome.
• Protein Description: Inhibits SNARE complex formation by absorbing free syntaxin-1..
• Protein Sequence: MAMSLPGSRRTSAGSRRRTSPPVSVRDAYGTSSLSSSSNSGSYKGSDSSPTPRRSMKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQNGMAKEDGTGESAGGSPARSLTRSSTYTKLSDPAVCGDRQPGDPSSGSAEDGADSGFAAADDTLSRTDALEASSLLSSGVDCGTEETSLHSSFGLGPRFPASNTYEKLLCGMEAGVQASCMQERAIQTDFVQYQPDLDTILEKVTQAQVCGTDPESGDRCPELDAHPSGPRDPNSAVVVTVGDELEAPEPITRGPTPQRPGANPNPGQSVSVVCPMEEEEEAAVAEKEPKSYWSRHYIVDLLAVVVPAVPTVAWLCRSQRRQGQPIYNISSLLRGCCTVALHSIRRISCRSLSQPSPSPAGGGSQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAMSLPGSRRTSAGS CCCCCCCCCCCCCCC	19.35	24719451
11	Phosphorylation	SLPGSRRTSAGSRRR CCCCCCCCCCCCCCC	23.09	-
12	Phosphorylation	LPGSRRTSAGSRRRT CCCCCCCCCCCCCCC	28.90	-
15	Phosphorylation	SRRTSAGSRRRTSPP CCCCCCCCCCCCCCC	23.48	24719451
19	Phosphorylation	SAGSRRRTSPPVSVR CCCCCCCCCCCCCHH	43.72	29691806
20	Phosphorylation	AGSRRRTSPPVSVRD CCCCCCCCCCCCHHH	25.95	29691806
29	Phosphorylation	PVSVRDAYGTSSLSS CCCHHHCCCCCCCCC	25.81	25332170
31	Phosphorylation	SVRDAYGTSSLSSSS CHHHCCCCCCCCCCC	11.49	25332170
33	Phosphorylation	RDAYGTSSLSSSSNS HHCCCCCCCCCCCCC	31.91	25332170
35	Phosphorylation	AYGTSSLSSSSNSGS CCCCCCCCCCCCCCC	30.07	30576142
36	Phosphorylation	YGTSSLSSSSNSGSY CCCCCCCCCCCCCCC	42.98	30576142
37	Phosphorylation	GTSSLSSSSNSGSYK CCCCCCCCCCCCCCC	30.11	-
41 (in isoform 2)	Phosphorylation	-	38.96	22210691
42	Phosphorylation	SSSSNSGSYKGSDSS CCCCCCCCCCCCCCC	24.40	30576142
43 (in isoform 2)	Phosphorylation	-	23.93	22210691
43	Phosphorylation	SSSNSGSYKGSDSSP CCCCCCCCCCCCCCC	23.93	-
71	Phosphorylation	NHGIKPPTPEQYLTP CCCCCCCCHHHHCCH	48.24	28348404
77	Phosphorylation	PTPEQYLTPLQQKEV CCHHHHCCHHHHHHH	19.61	28348404
90	Methylation	EVCIRHLKARLKDTQ HHHHHHHHHHCHHHH	25.90	-
90	Trimethylation	EVCIRHLKARLKDTQ HHHHHHHHHHCHHHH	25.90	-
90	Acetylation	EVCIRHLKARLKDTQ HHHHHHHHHHCHHHH	25.90	7850809
94	Methylation	RHLKARLKDTQDRLQ HHHHHHCHHHHHHHH	53.85	-
94	Acetylation	RHLKARLKDTQDRLQ HHHHHHCHHHHHHHH	53.85	7850817
94	Trimethylation	RHLKARLKDTQDRLQ HHHHHHCHHHHHHHH	53.85	-
111	Ubiquitination	DTEIDDLKTQLSRMQ CCHHHHHHHHHHHHH	41.02	-
136	Ubiquitination	VEAQLALKEARKEIK HHHHHHHHHHHHHHH	43.66	-
166	Phosphorylation	KDKGLQKYFVDINIQ CCCCHHHEEEEEEEC	8.89	-
200	Phosphorylation	KEDGTGESAGGSPAR CCCCCCCCCCCCCCC	33.29	29396893
204	Phosphorylation	TGESAGGSPARSLTR CCCCCCCCCCCCCCC	17.92	29396893
214	Phosphorylation	RSLTRSSTYTKLSDP CCCCCCCCCCCCCCC	36.13	-
219	Phosphorylation	SSTYTKLSDPAVCGD CCCCCCCCCCCCCCC	43.00	28348404
290	Phosphorylation	LGPRFPASNTYEKLL CCCCCCCCCHHHHHH	29.91	-
455	Phosphorylation	RRQGQPIYNISSLLR HHCCCCCCCHHHHHH	17.08	-
458	Phosphorylation	GQPIYNISSLLRGCC CCCCCCHHHHHHHHH	15.99	-
459	Phosphorylation	QPIYNISSLLRGCCT CCCCCHHHHHHHHHH	27.85	24719451
466	Phosphorylation	SLLRGCCTVALHSIR HHHHHHHHHHHHHHH	16.94	30576142
471	Phosphorylation	CCTVALHSIRRISCR HHHHHHHHHHHEECC	20.74	28787133
484	Phosphorylation	CRSLSQPSPSPAGGG CCCCCCCCCCCCCCC	30.30	25307156
486	Phosphorylation	SLSQPSPSPAGGGSQ CCCCCCCCCCCCCCC	31.55	25332170

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNPH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNPH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNPH_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SNPH_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.