SNG3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNG3_HUMAN
• UniProt AC: O43761
• Protein Name: Synaptogyrin-3 {ECO:0000305}
• Gene Name: SYNGR3 {ECO:0000312|HGNC:HGNC:11501}
• Organism: Homo sapiens (Human).
• Sequence Length: 229
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Cell junction, synapse . Found at the neuromuscular synapses.
• Protein Description: May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal..
• Protein Sequence: MEGASFGAGRAGAALDPVSFARRPQTLLRVASWVFSIAVFGPIVNEGYVNTDSGPELRCVFNGNAGACRFGVALGLGAFLACAAFLLLDVRFQQISSVRDRRRAVLLDLGFSGLWSFLWFVGFCFLTNQWQRTAPGPATTQAGDAARAAIAFSFFSILSWVALTVKALQRFRLGTDMSLFATEQLSTGASQAYPGYPVGSGVEGTETYQSPPFTETLDTSPKGYQVPAY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGASFGA -------CCCCCCCC	10.93	22223895
19	Phosphorylation	GAALDPVSFARRPQT CCCCCHHHHCCCHHH	20.69	24076635
96	Phosphorylation	DVRFQQISSVRDRRR HHHHHHHHCHHHHHH	20.60	24719451
139	Phosphorylation	RTAPGPATTQAGDAA HCCCCCCCCHHHHHH	23.68	25332170
140	Phosphorylation	TAPGPATTQAGDAAR CCCCCCCCHHHHHHH	20.66	25307156
175	Phosphorylation	LQRFRLGTDMSLFAT HHHHCCCCCHHHEEE	32.87	-
182	Phosphorylation	TDMSLFATEQLSTGA CCHHHEEEEECCCCC	19.55	-
220	Phosphorylation	FTETLDTSPKGYQVP CCCCCCCCCCCCCCC	25.04	25332170

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNG3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNG3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNG3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SNG3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.