SMYD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMYD4_HUMAN
• UniProt AC: Q8IYR2
• Protein Name: SET and MYND domain-containing protein 4
• Gene Name: SMYD4
• Organism: Homo sapiens (Human).
• Sequence Length: 804
• Protein Sequence: MDLPVDEWKSYLLQKWASLPTSVQVTISTAETLRDIFLHSSSLLQPEDELFLKRLSKGYLVGKDSDAPLFYREEGNKKFQEKDYTGAAVLYSKGVSHSRPNTEDMSLCHANRSAALFHLGQYETCLKDINRAQTHGYPERLQPKIMLRKAECLVALGRLQEASQTISDLERNFTATPALADVLPQTLQRNLHRLKMKMQEKDSLTESFPAALAKTLEDAALREENEQLSNASSSIGLCVDPLKGRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCLKHTLATVPCDGCSYAKYCSQECLQQAWELYHRTECPLGGLLLTLGVFCHIALRLTLLVGFEDVRKIITKLCDKISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDINGKYENNYNAVFNLLPHTENHSPEHKFLCALCVSALCRQLEAASLQAIPTERIVNSSQLKAAVTPELCPDVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNHSCSPNTSVSFISTVATIRASQRIRKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPACQTEAHRMAAGPRWEAFCCNSCGAPMQGDDVLRCGSRSCAESAVSRDHLVSRLQDLQQQVRVAQKLLRDGELERAVQRLSGCQRDAESFLWAEHAVVGEIADGLARACAALGDWQKSATHLQRSLYVVEVRHGPSSVEMGHELFKLAQIFFNGFAVPEALSTIQKAEEVLSLHCGPWDDEIQELQKMKSCLLDLPPTPVGPAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Ubiquitination	DLPVDEWKSYLLQKW CCCHHHHHHHHHHHH	27.46	29967540
53	Ubiquitination	PEDELFLKRLSKGYL CCCHHHHHHHHCCEE	43.91	-
57	Ubiquitination	LFLKRLSKGYLVGKD HHHHHHHCCEECCCC	57.05	-
63	Ubiquitination	SKGYLVGKDSDAPLF HCCEECCCCCCCCCE	46.72	29967540
144	Ubiquitination	YPERLQPKIMLRKAE CCHHHCHHHHHHHHH	27.99	29967540
149	Ubiquitination	QPKIMLRKAECLVAL CHHHHHHHHHHHHHH	44.57	29967540
165	Phosphorylation	RLQEASQTISDLERN HHHHHHHHHHHHHHH	21.69	-
186	Phosphorylation	LADVLPQTLQRNLHR HHHHHHHHHHHHHHH	23.95	27050516
214	Ubiquitination	SFPAALAKTLEDAAL HHHHHHHHHHHHHHH	55.27	29967540
243	Ubiquitination	GLCVDPLKGRCLVAT CEEECCCCCCEEEEE	50.09	29967540
377	Ubiquitination	LCDKISNKDICLPES HHHHHCCCCCCCCCC	41.50	29967540
389	Ubiquitination	PESNNQVKTLNYGLG CCCCCCEEEECCCCC	37.21	29967540
458	Phosphorylation	CRQLEAASLQAIPTE HHHHHHHHCCCCCHH	28.23	22210691
577	Ubiquitination	LHCYGPHKSRMGVAE EEECCCCHHCCCHHH	42.78	29967540
666	Ubiquitination	QQVRVAQKLLRDGEL HHHHHHHHHHHHCHH	39.49	-
717	Ubiquitination	AALGDWQKSATHLQR HHHCCHHHHHHHHHH	37.49	-
789	Ubiquitination	IQELQKMKSCLLDLP HHHHHHHHHHHCCCC	45.08	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMYD4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMYD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMYD4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SMYD4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.