SMS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMS1_HUMAN
• UniProt AC: Q86VZ5
• Protein Name: Phosphatidylcholine:ceramide cholinephosphotransferase 1
• Gene Name: SGMS1
• Organism: Homo sapiens (Human).
• Sequence Length: 413
• Subcellular Localization: Golgi apparatus membrane ; Multi-pass membrane protein .
• Protein Description: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide..
• Protein Sequence: MKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLCRVSSDNGQRLLDMIETLKMEHHLEAHKNGHANGHLNIGVDIPTPDGSFSIKIKPNGMPNGYRKEMIKIPMPELERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGMHFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MKEVVYWSPK -----CCCCEECCHH	20.90	29083192
5	Phosphorylation	---MKEVVYWSPKKV ---CCCCEECCHHHH	26.17	22468782
6	Phosphorylation	--MKEVVYWSPKKVA --CCCCEECCHHHHH	31.79	24114839
8	Phosphorylation	MKEVVYWSPKKVADW CCCCEECCHHHHHHH	47.66	23186163
10	Ubiquitination	EVVYWSPKKVADWLL CCEECCHHHHHHHHH	3.14	33845483
12	Phosphorylation	VYWSPKKVADWLLEN EECCHHHHHHHHHHC	12.82	29116813
14	Phosphorylation	WSPKKVADWLLENAM CCHHHHHHHHHHCCC	14.78	25159151
59	Phosphorylation	VSSDNGQRLLDMIET ECCCCHHHHHHHHHH	16.78	-
60	Phosphorylation	SSDNGQRLLDMIETL CCCCHHHHHHHHHHH	32.03	26853621
103	Phosphorylation	GSFSIKIKPNGMPNG CCEEEEECCCCCCCC	24.17	24719451
105	Phosphorylation	FSIKIKPNGMPNGYR EEEEECCCCCCCCCC	25.35	24719451
117	Ubiquitination	GYRKEMIKIPMPELE CCCHHCEECCCCHHH	25.75	33845483
117	Phosphorylation	GYRKEMIKIPMPELE CCCHHCEECCCCHHH	25.75	-
141	Phosphorylation	KTFLAFLYALSCFVL HHHHHHHHHHHHHHH	21.68	-
147	Phosphorylation	LYALSCFVLTTVMIS HHHHHHHHHHHHHHH	10.07	-
209	Phosphorylation	WLLLKYKSIISRRFF HHHHHHHHHHHHHHH	1.99	-
212	Phosphorylation	LKYKSIISRRFFCIV HHHHHHHHHHHHHHH	51.07	-
215	Phosphorylation	KSIISRRFFCIVGTL HHHHHHHHHHHHHHH	23.28	24719451
218	Phosphorylation	ISRRFFCIVGTLYLY HHHHHHHHHHHHHHH	18.74	24719451
239	Phosphorylation	VTTLPVPGMHFNCSP HHCCCCCCCCCCCCH	12.72	25404012
240	Phosphorylation	TTLPVPGMHFNCSPK HCCCCCCCCCCCCHH	21.01	25404012
251	Phosphorylation	CSPKLFGDWEAQLRR CCHHHHCCHHHHHHH	26.61	25404012
306	Phosphorylation	YSPRRLWWYHWICWL HCHHHHHHHHHHHHH	17.02	26091039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMS1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SMS1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.