SMOC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMOC2_HUMAN
• UniProt AC: Q9H3U7
• Protein Name: SPARC-related modular calcium-binding protein 2
• Gene Name: SMOC2
• Organism: Homo sapiens (Human).
• Sequence Length: 446
• Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane.
• Protein Description: Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis..
• Protein Sequence: MLLPQLCWLPLLAGLLPPVPAQKFSALTFLRVDQDKDKDCSLDCAGSPQKPLCASDGRTFLSRCEFQRAKCKDPQLEIAYRGNCKDVSRCVAERKYTQEQARKEFQQVFIPECNDDGTYSQVQCHSYTGYCWCVTPNGRPISGTAVAHKTPRCPGSVNEKLPQREGTGKTDDAAAPALETQPQGDEEDIASRYPTLWTEQVKSRQNKTNKNSVSSCDQEHQSALEEAKQPKNDNVVIPECAHGGLYKPVQCHPSTGYCWCVLVDTGRPIPGTSTRYEQPKCDNTARAHPAKARDLYKGRQLQGCPGAKKHEFLTSVLDALSTDMVHAASDPSSSSGRLSEPDPSHTLEERVVHWYFKLLDKNSSGDIGKKEIKPFKRFLRKKSKPKKCVKKFVEYCDVNNDKSISVQELMGCLGVAKEDGKADTKKRHTPRGHAESTSNRQPRKQG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Methylation	LSRCEFQRAKCKDPQ HHHHHHHHHCCCCCC	41.14	115917289
193	Phosphorylation	EEDIASRYPTLWTEQ HHHHHHHCCCHHHHH	9.70	18083107
206	N-linked_Glycosylation	EQVKSRQNKTNKNSV HHHHHHCCCCCCCCC	52.59	UniProtKB CARBOHYD
362	N-linked_Glycosylation	YFKLLDKNSSGDIGK HHHHHCCCCCCCCCC	40.86	UniProtKB CARBOHYD
363	O-linked_Glycosylation	FKLLDKNSSGDIGKK HHHHCCCCCCCCCCH	41.25	30620550
403	Phosphorylation	CDVNNDKSISVQELM HCCCCCCCEEHHHHH	23.98	24719451
414	Phosphorylation	QELMGCLGVAKEDGK HHHHHHHHHHHCCCC	22.78	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMOC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMOC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMOC2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SMOC2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 125400: Dentin dysplasia 1 (DTDP1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.