SMC4_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMC4_CAEEL
• UniProt AC: Q20060
• Protein Name: Structural maintenance of chromosomes protein 4
• Gene Name: smc-4
• Organism: Caenorhabditis elegans.
• Sequence Length: 1549
• Subcellular Localization: Nucleus . Chromosome . Localizes to condensed chromosomes during mitosis and meiosis. Localizes to chromosomes in a faint speckled pattern during prophase, then appears in two stripes outlining each chromosome during prometaphase. During metaphase, l
• Protein Description: Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. [PubMed: 11914278]
• Protein Sequence: MPPKTSAAPPQSDESDSDFDDAPVKKPQKKTTKPVNRHKEGSKDPEEELQRAVNEKFDGSDGEDDDSDLFSLQLPSRPDFLTKPNRADRLMIRNVEVDNFKSYFGKASIGPFHKSFTSIIGPNGSGKSNLIDSLLFVFGFRASKIRSAKVSNLIHKSAGRNPDKCTVTIHFQRIVDIPGHYEVVKDSEFTISRTAFQNNSSSYAIDGRPATKNEVEARLRRVDIDIEHNRFLILQGEVEQIAMMKPVKTTKSETGMVEYLEDIIGTNRLEPFVKLFQRRVNRLTCDLSQQRIARDHARNSKVAMENPVRAAIEFLMKENEATTIHMKLEQRRRQRYLDKIAPKQAELDKMKEEMKSIAETLDTNKNEYKQSEEAQKVMIEERSKLDKNFDSLSKELSDLGTEETRRKEALKRHQANISKAEAEKEKEVKKRSNLEAAPEKAERKIAKCQEEVEQLLEIEKTANEEADKNLDEFEKRSEAPKEEQKKIQETWAQKSNEFNKVRGEARIAREDFEDLKKLANSGTDKLIELKKRLESSEESYAKEKDELDKLKPEFDSWNDKLKQLSTELPTLRNTARQKNQDLAKTRDRLETLRQQNSSCSSSNKVIQALMKEKEAGRIKSFHGRLGDLGVIDPKYEGAICTNFGARLNYLIVGKEEDAKNVINFLVANKLPRQTVQPLDKIKCDKRDLAPNPTNPLPAPRLIDLIDCDPVLKPAFYDMVRSAIVGDSTQEAQRMHRMPACRGVTVCTLEGSMIHPSGSFTGGGKTVKGLILTDKNKMAKQVTPEDKAAERDLAEKLGKLRDEADELKGQEHEMDGQLIEARRKVAEMSNRLSIVTSSVQSAAPAIETLKKTIANQEKEAAKVKVDAKTLEDKQKIVEELEKKRDELGEEAAKVKARQAEIQSKLDGIFKELVQCHRDEAKESLQKRQKLEKDIAKETANISNSGRNIAKCDENISRHDKDIEKMKKKCEELMEKAIDDEEVKSKKETVERFEKQIKKLQTKGEEMTKKQSELSAAETKLEGELKKCSEGIKELKESMLADRLKVEDIEKKLAALKVNRIPRFQFLIESSRPEDLEMQIDDKMPVVDENQSPEEVERQKKHMACVMSDAAYALEFEMRQKVLENTESYENVDGEDRVPVELLSDEKINEISSRDAEEMQMKLKVCEQQVEALKAKVDISSIKAYVDKVKQYNEQVIKLTIATEVHRKHNQELQRIKQMRLEEFHSAFEFIGKHLVAVFKMLTDGGDAKLEYIDKDDPFRQGISFMVRPAKKAWKQIQFLSGGEKTLSSLALIFALHMFRPTPFYVMDEIDAALDYRNVSIIAQYVRQKTENAQFIIISLRNNMFELANRLVGIYKVDGCTRNVAIDPLRVCEMAKQITDSLGQATCTLPDEVTQRFNETMSRQNKEMIAQEKQYPNFPSSNEISKAEKIVNVEGRVRKELIQTTRDVTSRPQSKATTSGDGTERPASRSASRPESRINQMKYPAPRLVERSSSQNVRSPRKARNIEADETTPPSKRSNSASTPKRSPMKPLTPSSKKKEKAIVDDDDDME

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	VNRHKEGSKDPEEEL CCCCCCCCCCHHHHH	34.67	28854356
60	Phosphorylation	VNEKFDGSDGEDDDS HHHCCCCCCCCCCCC	44.26	28854356
1090	Phosphorylation	PVVDENQSPEEVERQ CCCCCCCCHHHHHHH	45.95	30078680
1466	Phosphorylation	DGTERPASRSASRPE CCCCCCCCCCCCCCH	29.47	30078680
1497	Phosphorylation	SSSQNVRSPRKARNI CCCCCCCCCHHHCCC	25.44	30078680
1509	Phosphorylation	RNIEADETTPPSKRS CCCCCCCCCCCCCCC	45.19	30078680
1510	Phosphorylation	NIEADETTPPSKRSN CCCCCCCCCCCCCCC	31.02	30078680
1518	Phosphorylation	PPSKRSNSASTPKRS CCCCCCCCCCCCCCC	25.50	30078680
1520	Phosphorylation	SKRSNSASTPKRSPM CCCCCCCCCCCCCCC	45.09	30078680
1521	Phosphorylation	KRSNSASTPKRSPMK CCCCCCCCCCCCCCC	32.33	30078680
1525	Phosphorylation	SASTPKRSPMKPLTP CCCCCCCCCCCCCCC	35.16	21082442
1531	Phosphorylation	RSPMKPLTPSSKKKE CCCCCCCCCCCCCCC	29.65	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMC4_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMC4_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMC4_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of SMC4_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.