| UniProt ID | SMC1_ARATH | |
|---|---|---|
| UniProt AC | Q6Q1P4 | |
| Protein Name | Structural maintenance of chromosomes protein 1 | |
| Gene Name | SMC1 | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 1218 | |
| Subcellular Localization | Nucleus. Chromosome. Associates with chromatin.. | |
| Protein Description | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity). Essential protein plant viability. Required for chromosome segregation (e.g. sister chromatid alignment) and cell division during embryogenesis.. | |
| Protein Sequence | MPAIQSPSGKILQLEMENFKSYKGHQLVGPFKDFTAIIGPNGSGKSNLMDAISFVLGVRTGQLRGSQLKDLIYAFDDRDKEQRGRKAFVRLVYQMDDGVELRFTRSITSAGGSEYRIDNRVVNLDEYNGKLRSLGILVKARNFLVFQGDVESIASKNPKELTGLLEEISGSEELKKEYEGLEEKKASAEEKAALIYQKKKTIGNEKKLKKAQKEEAEKHLRLQEELKALKRERFLWQLYNIENDIEKANEDVDSEKSNRKDVMRELEKFEREAGKRKVEQAKYLKEIAQREKKIAEKSSKLGKIQPELLRFKEEIARIKAKIETNRKDVDKRKKEKGKHSKEIEQMQKSIKELNKKMELFNKKRQDSSGKLPMLDSQLQDYFRLKEEAGMKTIKLRDEHEVLERQRRTDLEALRNLEENYQQLINRKNDLDEQIKRFKDRQGEIETSSSKYKNETTSLKTELRALQEKHVNAREASAKLKTRIAELEDQLSDLTAERYENERDSRLTQAVESLKRLFQGVHGRMTDLCRPNRKKYNLAVTVAMGRFMDAVVVEDENTGKDCIKYLKEQRLPPMTFIPLQSVRVKQVFERLRNLGGTAKLVFDVIQFDPELEKAVLYAVGNTLVCDELEEAKVLSWSGERFKVVTVDGILLTKAGTMTGGTSGGMEAKSNKWDDKKIEGLKKNKEDFEQQLENIGSIREMQMKESEISGKISGLEKKIQYAEIEKKSIKDKLPQLEQEERNIIEEIDRIKPELSKARTEVDKRKTEMNKLEKRMNEIVDRIYKDFSQSVGVPNIRVYEETQLKTAEKEAEERLELSNQLAKLKYQLEYEQNRDVGSRIRKIESSISSLETDLEGIQKTMSERKETAVKITNEINNWKKEMEECKQKSEEYEKEILDWKKQASQATTSITKLNRQIHSKETQIEQLISQKQEITEKCELEHITLPVLSDAMEEDDSDGPQFDFSELGRAYLQERRPSAREKVEAEFRQKIESKTSEIERTAPNLRALDQYEAIQEKEKQVSQEFEAARKEEKQVADAFNTVKQKRYELFMEAFNHIASNIDKIYKQLTKSNTHPLGGTAYLNLENEDDPFLHGIKYTTMPPTKRFRDMEQLSGGEKTVAALALLFSIHSYRPSPFFILDEVDAALDNLNVAKVAKFIRSKSCQAARDNQDAEDGNGFQSIVISLKDSFYDKAEALVGVYRDTERSCSSTMSFDLRNYQES | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 152 | Phosphorylation | VFQGDVESIASKNPK EEECCHHHHHCCCHH | 19880383 | ||
| 178 | Phosphorylation | SEELKKEYEGLEEKK CHHHHHHHCCHHHHH | 19880383 | ||
| 535 | Phosphorylation | CRPNRKKYNLAVTVA CCCCCCCCCEEEEHH | 24894044 | ||
| 557 | Phosphorylation | VVVEDENTGKDCIKY EEEECCCCCHHHHHH | 24894044 | ||
| 1207 | Phosphorylation | TERSCSSTMSFDLRN CCCCCCCCCCEECCC | 23572148 | ||
| 1227 | Phosphorylation | ---------------- ---------------- | 23572148 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SMC1_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SMC1_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SMC1_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SMC1_ARATH !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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