SLIK5_HUMAN - dbPTM
SLIK5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SLIK5_HUMAN
UniProt AC O94991
Protein Name SLIT and NTRK-like protein 5
Gene Name SLITRK5
Organism Homo sapiens (Human).
Sequence Length 958
Subcellular Localization Membrane
Single-pass type I membrane protein .
Protein Description Suppresses neurite outgrowth..
Protein Sequence MHTCCPPVTLEQDLHRKMHSWMLQTLAFAVTSLVLSCAETIDYYGEICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPSKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPASLGAGGGASSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHTSTNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHMCKNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGEEERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPKFPCSPAAYTFSPNYDLRRPHQYLHPGAGDSRLREPVLYSPPSAVFVEPNRNEYLELKAKLNVEPDYLEVLEKQTTFSQF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
77PhosphorylationIISLSEISPPRFPIY
EEEHHHCCCCCCCHH		25.4627486199
103N-linked_GlycosylationLYPNEFVNYTGASIL
HCCCCCCCCCCCCEE		33.69UniProtKB CARBOHYD
245PhosphorylationNCSCELISLKDWLDS
CCEEEEEEHHHHHHH		41.8324719451
301O-linked_GlycosylationMRPQTPLSTTGYLHT
CCCCCCCCCCCCCCC		25.73OGP
366O-linked_GlycosylationGPSIAYQTKSPVPLE
CCCCEEECCCCCCCC		22.3355830049
417PhosphorylationNPKKMYLTENYIAVV
CCCCEEECCCEEEEE		12.5122210691
420PhosphorylationKMYLTENYIAVVRRT
CEEECCCEEEEEECC		5.5222210691
446PhosphorylationHLGNNRISMIQDRAF
EECCCCEEHHHHHHH		13.44-
463PhosphorylationLTNLRRLYLNGNRIE
CCHHHEEHCCCCCHH		9.05-
485PhosphorylationYGLQSLQYLFLQYNL
HHHHHHHHHHHHHHH		12.52-
490PhosphorylationLQYLFLQYNLIREIQ
HHHHHHHHHHHHHHH		17.68-
541PhosphorylationNLRSNHFTSLPVSGV
CCCCCCCCCCCCCHH		23.0822210691
542PhosphorylationLRSNHFTSLPVSGVL
CCCCCCCCCCCCHHH		29.7222210691
644N-linked_GlycosylationVTPAVRLNSTGAPAS
CCCCEEECCCCCCCC		27.28UniProtKB CARBOHYD
714PhosphorylationVSSFNMQYSVYGGGG
CHHEEEEEEEECCCC		6.85-
717PhosphorylationFNMQYSVYGGGGGTG
EEEEEEEECCCCCCC		12.24-
743PhosphorylationPALPKVKTPAGHVYE
CCCCCCCCCCCCHHH		22.7429978859
749PhosphorylationKTPAGHVYEYIPHPL
CCCCCCHHHCCCCCC		9.4229978859
751PhosphorylationPAGHVYEYIPHPLGH
CCCCHHHCCCCCCHH		11.3229978859
767PhosphorylationCKNPIYRSREGNSVE
CCCCCHHCCCCCCCC		20.0829449344
772PhosphorylationYRSREGNSVEDYKDL
HHCCCCCCCCCCHHH		37.4329214152
776PhosphorylationEGNSVEDYKDLHELK
CCCCCCCCHHHHHCE		7.9029978859
777UbiquitinationGNSVEDYKDLHELKV
CCCCCCCHHHHHCEE		67.1629967540
825PhosphorylationGEEERRESHHLRSPA
CHHHHHHHHCCCCCC		17.8827642862
830PhosphorylationRESHHLRSPAYSVST
HHHHCCCCCCEECCC		21.9021945579
833PhosphorylationHHLRSPAYSVSTIEP
HCCCCCCEECCCCCC		17.0021945579
834PhosphorylationHLRSPAYSVSTIEPR
CCCCCCEECCCCCCH		16.2321945579
836PhosphorylationRSPAYSVSTIEPRED
CCCCEECCCCCCHHH		20.0921945579
837PhosphorylationSPAYSVSTIEPREDL
CCCEECCCCCCHHHH		27.4921945579
846PhosphorylationEPREDLLSPVQDADR
CCHHHHCCHHHCHHH		30.2621815630
855PhosphorylationVQDADRFYRGILEPD
HHCHHHHHHCCCCCC		14.6029978859
866PhosphorylationLEPDKHCSTTPAGNS
CCCCCCCCCCCCCCC		34.7329978859
867PhosphorylationEPDKHCSTTPAGNSL
CCCCCCCCCCCCCCC		42.0429978859
868PhosphorylationPDKHCSTTPAGNSLP
CCCCCCCCCCCCCCC		8.5429978859
873PhosphorylationSTTPAGNSLPEYPKF
CCCCCCCCCCCCCCC		44.3729978859
877PhosphorylationAGNSLPEYPKFPCSP
CCCCCCCCCCCCCCC		15.1327642862
888PhosphorylationPCSPAAYTFSPNYDL
CCCCCCEECCCCCCC		16.9527642862
893PhosphorylationAYTFSPNYDLRRPHQ
CEECCCCCCCCCCCC		21.5322817900
917PhosphorylationRLREPVLYSPPSAVF
CCCCCCCCCCCCCEE		21.2629978859
918PhosphorylationLREPVLYSPPSAVFV
CCCCCCCCCCCCEEE		26.6129978859
921PhosphorylationPVLYSPPSAVFVEPN
CCCCCCCCCEEECCC		40.2129978859
932PhosphorylationVEPNRNEYLELKAKL
ECCCCHHCCHHHHCC		14.7129978859
938UbiquitinationEYLELKAKLNVEPDY
HCCHHHHCCCCCHHH		38.7229967540
945PhosphorylationKLNVEPDYLEVLEKQ
CCCCCHHHHHHHHHH		18.5825884760
951UbiquitinationDYLEVLEKQTTFSQF
HHHHHHHHHCCCCCC		49.1129967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SLIK5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SLIK5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SLIK5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SLIK5_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SLIK5_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of HeLa cells using stable isotope labelingwith amino acids in cell culture (SILAC).";
Amanchy R., Kalume D.E., Iwahori A., Zhong J., Pandey A.;
J. Proteome Res. 4:1661-1671(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-833, AND MASSSPECTROMETRY.

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