SLIK2_HUMAN - dbPTM
SLIK2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SLIK2_HUMAN
UniProt AC Q9H156
Protein Name SLIT and NTRK-like protein 2
Gene Name SLITRK2
Organism Homo sapiens (Human).
Sequence Length 845
Subcellular Localization Membrane
Single-pass type I membrane protein . Cell membrane .
Protein Description It is involved in synaptogenesis and promotes excitatory synapse differentiation. [PubMed: 27273464]
Protein Sequence MLSGVWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDLCPRKSASDSSQRGSHADTHVQRLSPTMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICPDSPNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVPRNTNNLDVSSFQLQYGSYNTETHDKTDGHVYNYIPPPVGQMCQNPIYMQKEGDPVAYYRNLQEFSYSNLEEKKEEPATPAYTISATELLEKQATPREPELLYQNIAERVKELPSAGLVHYNFCTLPKRQFAPSYESRRQNQDRINKTVLYGTPRKCFVGQSKPNHPLLQAKPQSEPDYLEVLEKQTAISQL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MLSGVWFLSV
-----CCCHHHHHHH		29.9618187866
9PhosphorylationLSGVWFLSVLTVAGI
CCHHHHHHHHHHHHH		12.9522817900
12PhosphorylationVWFLSVLTVAGILQT
HHHHHHHHHHHHHCC		13.22-
19PhosphorylationTVAGILQTESRKTAK
HHHHHHCCCCHHHHH		32.2724719451
21PhosphorylationAGILQTESRKTAKDI
HHHHCCCCHHHHHHH		42.3324719451
84N-linked_GlycosylationLYPNEFVNYSNAVTL
CCCCCCCCCCCCEEE		39.58UniProtKB CARBOHYD
269O-linked_GlycosylationLCPRKSASDSSQRGS
CCCCCCCCCCCCCCC		45.1529351928
271O-linked_GlycosylationPRKSASDSSQRGSHA
CCCCCCCCCCCCCCC		26.3529351928
286PhosphorylationDTHVQRLSPTMNPAL
HHHHHHCCCCCCCCC		22.1022210691
288PhosphorylationHVQRLSPTMNPALNP
HHHHCCCCCCCCCCC		26.6324043423
296PhosphorylationMNPALNPTRAPKASR
CCCCCCCCCCCCCCC		38.0922210691
300AcetylationLNPTRAPKASRPPKM
CCCCCCCCCCCCCCC		58.997823339
302PhosphorylationPTRAPKASRPPKMRN
CCCCCCCCCCCCCCC		51.9922210691
306AcetylationPKASRPPKMRNRPTP
CCCCCCCCCCCCCCC		53.857823351
421N-linked_GlycosylationIQEGAFTNLTSLRRL
EECCCCCCHHHHHHH		34.56UniProtKB CARBOHYD
497PhosphorylationIFGGTALTRLNLRNN
CCCCCHHHHCCCCCC		30.55-
588PhosphorylationSPNLSDGTVLSMNHN
CCCCCCCCEEECCCC		24.2222817900
648AcetylationVFVLKRRKGVPSVPR
HHHHHCCCCCCCCCC		69.1930592449
732PhosphorylationEKKEEPATPAYTISA
HHCCCCCCCCEEEEH		21.11-
748PhosphorylationELLEKQATPREPELL
HHHHHCCCCCCHHHH		22.00-
756PhosphorylationPREPELLYQNIAERV
CCCHHHHHHHHHHHH		16.4927196784
787PhosphorylationPKRQFAPSYESRRQN
CHHHCCCCHHHHHCC		37.8024043423
788PhosphorylationKRQFAPSYESRRQNQ
HHHCCCCHHHHHCCH		19.5024043423
790PhosphorylationQFAPSYESRRQNQDR
HCCCCHHHHHCCHHH		25.2424043423
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SLIK2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SLIK2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SLIK2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SLIK2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SLIK2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-588, AND MASSSPECTROMETRY.

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