dbPTM

SLC31_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SLC31_HUMAN
UniProt AC	Q07837
Protein Name	Neutral and basic amino acid transport protein rBAT
Gene Name	SLC3A1
Organism	Homo sapiens (Human).
Sequence Length	685
Subcellular Localization	Membrane Single-pass type II membrane protein .
Protein Description	Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule..
Protein Sequence	MAEDKSKRDSIEMSMKGCQTNNGFVHNEDILEQTPDPGSSTDNLKHSTRGILGSQEPDFKGVQPYAGMPKEVLFQFSGQARYRIPREILFWLTVASVLVLIAATIAIIALSPKCLDWWQEGPMYQIYPRSFKDSNKDGNGDLKGIQDKLDYITALNIKTVWITSFYKSSLKDFRYGVEDFREVDPIFGTMEDFENLVAAIHDKGLKLIIDFIPNHTSDKHIWFQLSRTRTGKYTDYYIWHDCTHENGKTIPPNNWLSVYGNSSWHFDEVRNQCYFHQFMKEQPDLNFRNPDVQEEIKEILRFWLTKGVDGFSLDAVKFLLEAKHLRDEIQVNKTQIPDTVTQYSELYHDFTTTQVGMHDIVRSFRQTMDQYSTEPGRYRFMGTEAYAESIDRTVMYYGLPFIQEADFPFNNYLSMLDTVSGNSVYEVITSWMENMPEGKWPNWMIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGIDRIFIVVLNFGESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLNILYTSC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 4)	Phosphorylation	-	33.42	30257219
6	Phosphorylation	--MAEDKSKRDSIEM --CCCCHHHHHHHHH	45.29	28857561
10	Phosphorylation	EDKSKRDSIEMSMKG CCHHHHHHHHHHHCC	25.20	28857561
14	Phosphorylation	KRDSIEMSMKGCQTN HHHHHHHHHCCHHCC	12.45	24719451
39	Phosphorylation	EQTPDPGSSTDNLKH HHCCCCCCCCCCCCC	35.14	28857561
40	Phosphorylation	QTPDPGSSTDNLKHS HCCCCCCCCCCCCCC	45.77	28857561
41	Phosphorylation	TPDPGSSTDNLKHST CCCCCCCCCCCCCCC	30.51	28857561
47	Phosphorylation	STDNLKHSTRGILGS CCCCCCCCCCCCCCC	20.43	28857561
48	Phosphorylation	TDNLKHSTRGILGSQ CCCCCCCCCCCCCCC	32.41	28857561
54	Phosphorylation	STRGILGSQEPDFKG CCCCCCCCCCCCCCC	28.11	28857561
111	Phosphorylation	TIAIIALSPKCLDWW HHHHHHCCHHHHHHH	17.19	24719451
134	Phosphorylation	YPRSFKDSNKDGNGD CCCCCCCCCCCCCCC	46.50	26270265
214	N-linked_Glycosylation	LIIDFIPNHTSDKHI EEEEECCCCCCCCEE	46.37	UniProtKB CARBOHYD
236	Phosphorylation	RTGKYTDYYIWHDCT CCCCCCCEEEEEECC	6.77	22817900
243	Phosphorylation	YYIWHDCTHENGKTI EEEEEECCCCCCCCC	37.98	22817900
261	N-linked_Glycosylation	NWLSVYGNSSWHFDE CEEEEECCCCCCHHH	18.38	UniProtKB CARBOHYD
332	N-linked_Glycosylation	LRDEIQVNKTQIPDT HHHHHCCCCCCCCCH	25.86	UniProtKB CARBOHYD
367	Phosphorylation	IVRSFRQTMDQYSTE HHHHHHHHHHHHCCC	20.61	24043423
371	Phosphorylation	FRQTMDQYSTEPGRY HHHHHHHHCCCCCCE	17.19	24043423
372	Phosphorylation	RQTMDQYSTEPGRYR HHHHHHHCCCCCCEE	22.21	24043423
373	Phosphorylation	QTMDQYSTEPGRYRF HHHHHHCCCCCCEEE	41.06	24043423
378	Phosphorylation	YSTEPGRYRFMGTEA HCCCCCCEEECCCHH	17.70	24043423
461	Phosphorylation	TSRLGNQYVNVMNML HHHHHHHHHCCEEHH	9.67	-
495	N-linked_Glycosylation	NIVAANLNESYDINT CEEEEECCCCCCCCC	35.66	UniProtKB CARBOHYD
513	N-linked_Glycosylation	KSPMQWDNSSNAGFS CCCCCCCCCCCCCCC	44.36	UniProtKB CARBOHYD
575	N-linked_Glycosylation	GWFCHLRNDSHYVVY CCEEECCCCCCEEEE	62.59	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SLC31_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SLC31_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SLC31_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SLC31_HUMAN !!

Drug and Disease Associations

Kegg Disease
H00901	Cystinuria
OMIM Disease
220100	Cystinuria (CSNU)
606407	Hypotonia-cystinuria syndrome (HCS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00138	L-Cystine

Regulatory Network of SLC31_HUMAN

Related Literatures of Post-Translational Modification