SKN1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SKN1_CAEEL
• UniProt AC: P34707
• Protein Name: Protein skinhead-1
• Gene Name: skn-1
• Organism: Caenorhabditis elegans.
• Sequence Length: 623
• Subcellular Localization: Nucleus . Cytoplasm . In absence of stress, localizes in the cytoplasm of intestinal cells. Upon paraquat or arsenite treatments or upon bacterial infection, localizes in the nucleus (PubMed:16166371, PubMed:22216003). Nuclear localization is regulat
• Protein Description: Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. [PubMed: 1547503]
• Protein Sequence: MGGSSRRQRSTSATRRDDKRRRRQCFSSVADDEEETTSIYGVSSIFIWILATSSLILVISSPSSNTSIQSSSYDRITTKHLLDNISPTFKMYTDSNNRNFDEVNHQHQQEQDFNGQSKYDYPQFNRPMGLRWRDDQRMMEYFMSNGPVETVPVMPILTEHPPASPFGRGPSTERPTTSSRYEYSSPSLEDIDLIDVLWRSDIAGEKGTRQVAPADQYECDLQTLTEKSTVAPLTAEENARYEDLSKGFYNGFFESFNNNQYQQKHQQQQREQIKTPTLEHPTQKAELEDDLFDEDLAQLFEDVSREEGQLNQLFDNKQQHPVINNVSLSEGIVYNQANLTEMQEMRDSCNQVSISTIPTTSTAQPETLFNVTDSQTVEQWLPTEVVPNDVFPTSNYAYIGMQNDSLQAVVSNGQIDYDHSYQSTGQTPLSPLIIGSSGRQQQTQTSPGSVTVTATATQSLFDPYHSQRHSFSDCTTDSSSTCSRLSSESPRYTSESSTGTHESRFYGKLAPSSGSRYQRSSSPRSSQSSIKIARVVPLASGQRKRGRQSKDEQLASDNELPVSAFQISEMSLSELQQVLKNESLSEYQRQLIRKIRRRGKNKVAARTCRQRRTDRHDKMSHYI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
164	Phosphorylation	LTEHPPASPFGRGPS EECCCCCCCCCCCCC	26.91	16166371
394	Phosphorylation	PNDVFPTSNYAYIGM CCCCCCCCCCEEEEE	28.25	18358814
430	Phosphorylation	STGQTPLSPLIIGSS CCCCCCCCCEEECCC	20.90	16166371
470	O-linked_Glycosylation	PYHSQRHSFSDCTTD CCCCCCCCCCCCCCC	28.74	28272406
493	O-linked_Glycosylation	SSESPRYTSESSTGT CCCCCCCCCCCCCCC	27.57	28272406

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
164	S	Phosphorylation	Kinase	PMK-1	Q17446	Uniprot
394	S	Phosphorylation	Kinase	GSK-3	Q9U2Q9	GPS
430	S	Phosphorylation	Kinase	PMK-1	Q17446	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	eel-1	Q9GUP2	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SKN1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SKN1_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCA11_CAEEL	wdr-23	genetic	23555279

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.