SIX2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIX2_MOUSE
• UniProt AC: Q62232
• Protein Name: Homeobox protein SIX2
• Gene Name: Six2
• Organism: Mus musculus (Mouse).
• Sequence Length: 296
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. [PubMed: 20515681 During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1]
• Protein Sequence: MSMLPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENSENSNSSSHNPLASSLNGSGKSVLGSSEDEKTPSGTPDHSSSSPALLLSPPPPPGLPSLHSLGHPPGPSAVPVPVPGGGGADPLQHHHSLQDSILNPMSANLVDLGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSMLPTFGF ------CCCCCCCCC	29.09	25293948
6	Phosphorylation	--MSMLPTFGFTQEQ --CCCCCCCCCCHHH	32.22	25293948
10	Phosphorylation	MLPTFGFTQEQVACV CCCCCCCCHHHHHHH	31.41	25293948
215	Phosphorylation	SGKSVLGSSEDEKTP CCCCCCCCCCCCCCC	26.79	29550500
216	Phosphorylation	GKSVLGSSEDEKTPS CCCCCCCCCCCCCCC	47.47	29550500

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIX2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIX2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIX2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SIX2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.