dbPTM

SIL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SIL1_MOUSE
UniProt AC	Q9EPK6
Protein Name	Nucleotide exchange factor SIL1
Gene Name	Sil1
Organism	Mus musculus (Mouse).
Sequence Length	465
Subcellular Localization	Endoplasmic reticulum lumen .
Protein Description	Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5 (By similarity)..
Protein Sequence	MAPQHLPSTRMASPGMLLGLLLTSCLTLCLSCQNSNNFALTNPEKSIHQESDTKETREEEELDTEILEVFHPTQEWQTLQPGQAVPAGSHVRMNLQTGVNEVKLQQEDKFQNNLKGFKRGRRLDINANTYTSQDLKSALAKFKEGTEMENSKDELARQATVKQLFRPIEELKKEFDELNVVLETDMQIMVRLINKFNSSSSSLEEKVAALFDLEYYVHQMDNAQDLLSFGGLQVVINGLNSTEPLVKEYAAFVLGAAFSSNPKVQVEAIEGGALQKLLVILATNQPLPAKKKVLFALCSLLRHFPYAQQQFLKLGGLQVLRSLVQEKSAKVLAVRVVTLLYDLVTEKMFAEEEAELTQDSSPEKLQQYRQVQLLPGLQEQGWCEITAQLLALPEHDAREKVLQTLGALLTTCRDRYRQDLQLSRTLGRLQAEYQALASLELQEGEDDGYFRELLASINSLMKELR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Phosphorylation	SIHQESDTKETREEE CCCCCCCCCHHHHHH	39.81	27841257
115	Ubiquitination	DKFQNNLKGFKRGRR HHHHHHCCCHHCCCC	65.51	-
129	Phosphorylation	RLDINANTYTSQDLK CCCCCCCCCCCHHHH	26.26	28059163
130	Phosphorylation	LDINANTYTSQDLKS CCCCCCCCCCHHHHH	12.28	28059163
197	N-linked_Glycosylation	VRLINKFNSSSSSLE HHHHHHCCCCCCCHH	42.46	-
199	Phosphorylation	LINKFNSSSSSLEEK HHHHCCCCCCCHHHH	35.03	25521595
201	Phosphorylation	NKFNSSSSSLEEKVA HHCCCCCCCHHHHHH	40.67	25521595
240	N-linked_Glycosylation	QVVINGLNSTEPLVK EEEECCCCCCCHHHH	48.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SIL1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SIL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SIL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SIL1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SIL1_MOUSE

Related Literatures of Post-Translational Modification