dbPTM

SIL1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SIL1_DROME
UniProt AC	Q9VBV5
Protein Name	Nucleotide exchange factor SIL1
Gene Name	CG10420
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	429
Subcellular Localization	Endoplasmic reticulum lumen.
Protein Description	Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for an ER lumenal chaperone of HSP70 family (By similarity)..
Protein Sequence	MSGKQVVILLGSVLILGCLQVAAATETDNKTNDFVATDEWQTIAEGQAIPRGLHVRINLQTGLKEAKLLDESERGTSLQSQPDDQNARESHDDNEPLALDYKPDIIEESIRRVKEQKKSYAELRKAYKEFQKNFRTDGELIVQLIDQFRNFSRTPLESEMRSKLDCLENLEYLLHQIDNALMFIDNGGLDDVLLPIVVNDTSTSLRVSAMRVLGSLASNNPKAQIKVFEKNFGSHLAQILTSSGNVGEISAALHAFGALLRKFPLAQQRVLSTSGTQALIKVLQSPDVELRSKAKVVTLISDLVLEKRSVLDVSKDDPEASSTMAQYVLLDFESWLKTPGYCAAVDTVLTKEFLLLLEQPEVVEQFATALETTEDMCTSTWSQSSGLRHALLTVRNRYANSTDEYRLEVSQILAKLCERLFNKPKHTEL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	N-linked_Glycosylation	AAATETDNKTNDFVA HHHHCCCCCCCCEEC	61.54	-
150	N-linked_Glycosylation	QLIDQFRNFSRTPLE HHHHHHHCCCCCCCH	40.30	-
199	N-linked_Glycosylation	VLLPIVVNDTSTSLR EEEEEEECCCCCCHH	35.63	-
400	N-linked_Glycosylation	TVRNRYANSTDEYRL HHHHHHCCCCCHHHH	36.19	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SIL1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SIL1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SIL1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SIL1_DROME

Related Literatures of Post-Translational Modification