dbPTM

SIGA_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SIGA_ARATH
UniProt AC	O24629
Protein Name	RNA polymerase sigma factor sigA
Gene Name	SIGA
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	502
Subcellular Localization	Plastid, chloroplast .
Protein Description	Essential protein. Sigma factors are initiation factors that promote the attachment of plastid-encoded RNA polymerase (PEP) to specific initiation sites and are then released. Controls the transcription of the psaA gene and thus modulates photosystem stoichiometry. Thereby maintains a harmonious electron flow and photosynthetic efficiency..
Protein Sequence	MATAAVIGLNTGKRLLSSSFYHSDVTEKFLSVNDHCSSQYHIASTKSGITAKKASNYSPSFPSSNRHTQSAKALKESVDVASTEKPWLPNGTDKELEEECYDDDDLISHSVEAILLLQKSMLEKSWNLSFEKAVSSEYPGKGTIRKKKIPVITCSGISARQRRIGAKKKTNMTHVKAVSDVSSGKQVRGYVKGVISEDVLSHVEVVRLSKKIKSGLRLDDHKSRLKDRLGCEPSDEQLAVSLKISRAELQAWLMECHLAREKLAMSNVRLVMSIAQRYDNLGAEMSDLVQGGLIGLLRGIEKFDSSKGFRISTYVYWWIRQGVSRALVDNSRTLRLPTHLHERLGLIRNAKLRLQEKGITPSIDRIAESLNMSQKKVRNATEAVSKVFSLDRDAFPSLNGLPGETHHSYIADTRLENNPWHGYDDLALKEEVSKLISATLGEREKEIIRLYYGLDKECLTWEDISKRIGLSRERVRQVGLVALEKLKHAARKRKMEAMILKN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
170	Phosphorylation	RIGAKKKTNMTHVKA HHCCCCCCCCCEEEE	38.82	20498041

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SIGA_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
170	T	Oxidation	20498041
The phosphorylation of Thr-170 mediated by oxidative conditions of plastoquinone (PQ) changes the promoter specificity, selectively inhibiting the transcription of the psaA gene, which encodes a PS-I protein.
170	T	Phosphorylation	20498041
The phosphorylation of Thr-170 mediated by oxidative conditions of plastoquinone (PQ) changes the promoter specificity, selectively inhibiting the transcription of the psaA gene, which encodes a PS-I protein.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SIGA_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SIGA_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SIGA_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Sigma factor phosphorylation in the photosynthetic control ofphotosystem stoichiometry."; Shimizu M., Kato H., Ogawa T., Kurachi A., Nakagawa Y., Kobayashi H.; Proc. Natl. Acad. Sci. U.S.A. 107:10760-10764(2010). Cited for: PHOSPHORYLATION AT THR-170, AND MUTAGENESIS OF THR-170.	20498041 [Abstract]