SIAT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIAT2_HUMAN
• UniProt AC: Q96JF0
• Protein Name: Beta-galactoside alpha-2,6-sialyltransferase 2
• Gene Name: ST6GAL2
• Organism: Homo sapiens (Human).
• Sequence Length: 529
• Subcellular Localization: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
• Protein Description: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids..
• Protein Sequence: MKPHLKQWRQRMLFGIFAWGLLFLLIFIYFTDSNPAEPVPSSLSFLETRRLLPVQGKQRAIMGAAHEPSPPGGLDARQALPRAHPAGSFHAGPGDLQKWAQSQDGFEHKEFFSSQVGRKSQSAFYPEDDDYFFAAGQPGWHSHTQGTLGFPSPGEPGPREGAFPAAQVQRRRVKKRHRRQRRSHVLEEGDDGDRLYSSMSRAFLYRLWKGNVSSKMLNPRLQKAMKDYLTANKHGVRFRGKREAGLSRAQLLCQLRSRARVRTLDGTEAPFSALGWRRLVPAVPLSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPSHHFIDSSLYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYIQHRQRNPNQPFYILHPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHPLLYEKLLVQRLNMGTQGDLHRKGKVVLPGFQAVHCPAPSPVIPHS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	O-linked_Glycosylation	NPAEPVPSSLSFLET CCCCCCCCCHHHHHH	44.11	OGP
69	O-linked_Glycosylation	MGAAHEPSPPGGLDA HCCCCCCCCCCCCCH	40.52	55835435
102	O-linked_Glycosylation	DLQKWAQSQDGFEHK CHHHHHHCCCCCCCH	23.61	55824263
113	Phosphorylation	FEHKEFFSSQVGRKS CCCHHHHHHHCCCCC	25.78	-
114	Phosphorylation	EHKEFFSSQVGRKSQ CCHHHHHHHCCCCCC	24.59	-
211	N-linked_Glycosylation	LYRLWKGNVSSKMLN HHHHHCCCCCHHHCC	27.11	UniProtKB CARBOHYD
228	Phosphorylation	LQKAMKDYLTANKHG HHHHHHHHHHHHHCC	10.63	28060719
230	Phosphorylation	KAMKDYLTANKHGVR HHHHHHHHHHHCCCC	23.19	28060719
339	Phosphorylation	EKDVGNKTTIRIINS CCCCCCCEEEEEECC	31.30	27251275
340	Phosphorylation	KDVGNKTTIRIINSQ CCCCCCEEEEEECCC	15.18	27251275
346	Phosphorylation	TTIRIINSQILTNPS EEEEEECCCCCCCCC	14.27	27251275
353	Phosphorylation	SQILTNPSHHFIDSS CCCCCCCCCCCCCCH	31.50	27251275
359	Phosphorylation	PSHHFIDSSLYKDVI CCCCCCCCHHCCCEE	19.89	27251275
360	Phosphorylation	SHHFIDSSLYKDVIL CCCCCCCHHCCCEEE	31.78	27251275
362	Phosphorylation	HFIDSSLYKDVILVA CCCCCHHCCCEEEEE	13.69	27251275
375	Phosphorylation	VAWDPAPYSANLNLW EECCCCCCCCCCCEE	23.63	26074081
376	Phosphorylation	AWDPAPYSANLNLWY ECCCCCCCCCCCEEE	15.04	26074081
383	Phosphorylation	SANLNLWYKKPDYNL CCCCCEEECCCCCCC	16.58	26074081
436	Phosphorylation	IQPNPPSSGFIGILI CCCCCCCCCHHHHHH	43.42	-
523	O-linked_Glycosylation	AVHCPAPSPVIPHS- EEECCCCCCCCCCC-	33.63	55826393
529	O-linked_Glycosylation	PSPVIPHS------- CCCCCCCC-------	36.24	55826399

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIAT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIAT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIAT2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SIAT2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.