SIA8F_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIA8F_HUMAN
• UniProt AC: P61647
• Protein Name: Alpha-2,8-sialyltransferase 8F
• Gene Name: ST8SIA6
• Organism: Homo sapiens (Human).
• Sequence Length: 398
• Subcellular Localization: Golgi apparatus membrane ; Single-pass type II membrane protein .
• Protein Description: Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity)..
• Protein Sequence: MRPGGALLALLASLLLLLLLRLLWCPADAPGRARILVEESREATHGTPAALRTLRSPATAVPRATNSTYLNEKSLQLTEKCKNLQYGIESFSNKTKGYSENDYLQIITDIQSCPWKRQAEEYANFRAKLASCCDAVQNFVVSQNNTPVGTNMSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGDVSKDVGSKTNLVTINPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEESKARQKVLFFHPKYLKDLALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNKLPKHGFHQMPKEYSQILQLHMKGILKLQFSKCEVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	ARILVEESREATHGT EEEEEECHHHHHCCC	23.16	24719451
44	Phosphorylation	VEESREATHGTPAAL EECHHHHHCCCHHHH	18.98	24719451
65	Phosphorylation	ATAVPRATNSTYLNE CCCCCCCCCCHHCCH	30.86	29759185
66	N-linked_Glycosylation	TAVPRATNSTYLNEK CCCCCCCCCHHCCHH	31.22	UniProtKB CARBOHYD
67	Phosphorylation	AVPRATNSTYLNEKS CCCCCCCCHHCCHHH	17.67	29759185
78	Phosphorylation	NEKSLQLTEKCKNLQ CHHHHHHHHHHHHCH	22.04	29759185
92	Ubiquitination	QYGIESFSNKTKGYS HHHHHHCCCCCCCCC	46.85	22817900
93	N-linked_Glycosylation	YGIESFSNKTKGYSE HHHHHCCCCCCCCCC	54.74	UniProtKB CARBOHYD
97	Ubiquitination	SFSNKTKGYSENDYL HCCCCCCCCCCCCHH	36.11	22817900
151	N-linked_Glycosylation	NNTPVGTNMSYEVES CCCCCCCCEEEEEEC	16.09	UniProtKB CARBOHYD
196	N-linked_Glycosylation	VGNGGILNKSLCGTE EECCCCCCHHHCCCC	29.92	UniProtKB CARBOHYD
213	Ubiquitination	KSDFVFRCNLPPTTG CCCEEEEECCCCCCC	4.10	22817900
218	Ubiquitination	FRCNLPPTTGDVSKD EEECCCCCCCCCCCC	41.28	22817900
218	Phosphorylation	FRCNLPPTTGDVSKD EEECCCCCCCCCCCC	41.28	22468782
238	Phosphorylation	NLVTINPSIITLKYG CEEEECCCCEEEECC	23.33	22468782
243	Ubiquitination	NPSIITLKYGNLKEK CCCCEEEECCCCCCC	42.32	22817900
248	Acetylation	TLKYGNLKEKKALFL EEECCCCCCCEEEEH	72.06	7825145
248	Ubiquitination	TLKYGNLKEKKALFL EEECCCCCCCEEEEH	72.06	22817900
272	Phosphorylation	FFLLPAFSFRANTGT EEEEEEEEEECCCCC	18.87	24719451
284	Phosphorylation	TGTSFKVYYTLEESK CCCEEEEEEEECHHH	7.42	25072903
285	Phosphorylation	GTSFKVYYTLEESKA CCEEEEEEEECHHHH	14.08	25072903
286	Phosphorylation	TSFKVYYTLEESKAR CEEEEEEEECHHHHC	15.26	25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIA8F_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIA8F_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIA8F_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SIA8F_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.