dbPTM

SIA7B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SIA7B_HUMAN
UniProt AC	Q9UJ37
Protein Name	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Gene Name	ST6GALNAC2
Organism	Homo sapiens (Human).
Sequence Length	374
Subcellular Localization	Golgi apparatus membrane Single-pass type II membrane protein .
Protein Description	Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins..
Protein Sequence	MGLPRGSFFWLLLLLTAACSGLLFALYFSAVQRYPGPAAGARDTTSFEAFFQSKASNSWTGKGQACRHLLHLAIQRHPHFRGLFNLSIPVLLWGDLFTPALWDRLSQHKAPYGWRGLSHQVIASTLSLLNGSESAKLFAPPRDTPPKCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVSYWNLGFTSVPQGQDLQYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHAYFGPEASASKFKLLHPDFISYLTERFLKSKLINTHFGDLYMPSTGALMLLTALHTCDQVSAYGFITSNYWKFSDHYFERKMKPLIFYANHDLSLEAALWRDLHKAGILQLYQR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	YFSAVQRYPGPAAGA HHHHHHHCCCCCCCC	8.75	-
85	N-linked_Glycosylation	PHFRGLFNLSIPVLL CCHHHHHCCCCCCHH	37.61	29251719
127	Phosphorylation	QVIASTLSLLNGSES HHHHHHHHHHCCCCC	30.79	-
130	N-linked_Glycosylation	ASTLSLLNGSESAKL HHHHHHHCCCCCCCC	58.18	29251719
132	Phosphorylation	TLSLLNGSESAKLFA HHHHHCCCCCCCCCC	27.57	-
161	N-linked_Glycosylation	VGNGGILNGSRQGPN ECCCCCCCCCCCCCC	44.46	29251719
194	Phosphorylation	ERDVGTKTSFYGFTV ECCCCCCCEEEEEEE	24.73	28985074
195	Phosphorylation	RDVGTKTSFYGFTVN CCCCCCCEEEEEEEC	20.30	28985074
197	Phosphorylation	VGTKTSFYGFTVNTM CCCCCEEEEEEECCC	15.88	28985074
217	O-linked_Glycosylation	SYWNLGFTSVPQGQD HHHCCCCCCCCCCCC	27.32	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SIA7B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SIA7B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SIA7B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SIA7B_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SIA7B_HUMAN

Related Literatures of Post-Translational Modification