SIA7A_HUMAN - dbPTM
SIA7A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SIA7A_HUMAN
UniProt AC Q9NSC7
Protein Name Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Gene Name ST6GALNAC1
Organism Homo sapiens (Human).
Sequence Length 600
Subcellular Localization Golgi apparatus membrane
Single-pass type II membrane protein .
Protein Description
Protein Sequence MRSCLWRCRHLSQGVQWSLLLAVLVFFLFALPSFIKEPQTKPSRHQRTENIKERSLQSLAKPKSQAPTRARRTTIYAEPVPENNALNTQTQPKAHTTGDRGKEANQAPPEEQDKVPHTAQRAAWKSPEKEKTMVNTLSPRGQDAGMASGRTEAQSWKSQDTKTTQGNGGQTRKLTASRTVSEKHQGKAATTAKTLIPKSQHRMLAPTGAVSTRTRQKGVTTAVIPPKEKKPQATPPPAPFQSPTTQRNQRLKAANFKSEPRWDFEEKYSFEIGGLQTTCPDSVKIKASKSLWLQKLFLPNLTLFLDSRHFNQSEWDRLEHFAPPFGFMELNYSLVQKVVTRFPPVPQQQLLLASLPAGSLRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAFSLTQSLLILGNRGFKNVPLGKDVRYLHFLEGTRDYEWLEALLMNQTVMSKNLFWFRHRPQEAFREALHMDRYLLLHPDFLRYMKNRFLRSKTLDGAHWRIYRPTTGALLLLTALQLCDQVSAYGFITEGHERFSDHYYDTSWKRLIFYINHDFKLEREVWKRLHDEGIIRLYQRPGPGTAKAKN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
33PhosphorylationFFLFALPSFIKEPQT
HHHHHHHHHCCCCCC		40.2224719451
58PhosphorylationIKERSLQSLAKPKSQ
HHHHHHHHHHCCHHH		35.2724719451
73PhosphorylationAPTRARRTTIYAEPV
CCCCCCCCEEECEEC		16.4023312004
74PhosphorylationPTRARRTTIYAEPVP
CCCCCCCEEECEECC		15.3523312004
76PhosphorylationRARRTTIYAEPVPEN
CCCCCEEECEECCCC		11.6523312004
138PhosphorylationKTMVNTLSPRGQDAG
HHHCCCCCCCCCCCC		15.5422817900
148PhosphorylationGQDAGMASGRTEAQS
CCCCCCCCCCCCHHH		21.66-
151O-linked_GlycosylationAGMASGRTEAQSWKS
CCCCCCCCCHHHHHC		38.92OGP
155PhosphorylationSGRTEAQSWKSQDTK
CCCCCHHHHHCCCCC		43.44-
161PhosphorylationQSWKSQDTKTTQGNG
HHHHCCCCCCCCCCC		23.7423532336
179O-linked_GlycosylationRKLTASRTVSEKHQG
EEEEECCCCCHHHCC		26.36OGP
181PhosphorylationLTASRTVSEKHQGKA
EEECCCCCHHHCCCC		40.0726670566
190PhosphorylationKHQGKAATTAKTLIP
HHCCCCCCCHHHHCC		31.95-
199PhosphorylationAKTLIPKSQHRMLAP
HHHHCCHHHHCCCCC		26.34-
220PhosphorylationRTRQKGVTTAVIPPK
CCCCCCCEEEECCCC		20.08-
221PhosphorylationTRQKGVTTAVIPPKE
CCCCCCEEEECCCCC		19.27-
227MethylationTTAVIPPKEKKPQAT
EEEECCCCCCCCCCC		76.4523644510
234O-linked_GlycosylationKEKKPQATPPPAPFQ
CCCCCCCCCCCCCCC		30.95OGP
288PhosphorylationDSVKIKASKSLWLQK
CCCEEEECCCHHHHH		20.1326074081
290PhosphorylationVKIKASKSLWLQKLF
CEEEECCCHHHHHHH		23.4526074081
300N-linked_GlycosylationLQKLFLPNLTLFLDS
HHHHHCCCEEEEECC		48.05UniProtKB CARBOHYD
302PhosphorylationKLFLPNLTLFLDSRH
HHHCCCEEEEECCCC		23.3125690035
307PhosphorylationNLTLFLDSRHFNQSE
CEEEEECCCCCCHHH		29.7825690035
311N-linked_GlycosylationFLDSRHFNQSEWDRL
EECCCCCCHHHHHHH		38.04UniProtKB CARBOHYD
331N-linked_GlycosylationPFGFMELNYSLVQKV
CCCCHHCCHHHHHHH		15.84UniProtKB CARBOHYD
375N-linked_GlycosylationVGNGGILNNSHMGQE
ECCCCCCCCCCCCCC		46.14UniProtKB CARBOHYD
393PhosphorylationHDYVFRLSGALIKGY
CCCEEHHHCCEEEEE		20.1224719451
460N-linked_GlycosylationWLEALLMNQTVMSKN
HHHHHHHCCCHHHCC		34.05UniProtKB CARBOHYD
564PhosphorylationSWKRLIFYINHDFKL
CCHHEEEEECCCCHH		8.20-
595O-linked_GlycosylationYQRPGPGTAKAKN--
EECCCCCCCCCCC--		28.2855834623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SIA7A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SIA7A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SIA7A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EF1A2_HUMANEEF1A2physical
28514442
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SIA7A_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, AND MASSSPECTROMETRY.

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