dbPTM

SI1L1_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SI1L1_RAT
UniProt AC	O35412
Protein Name	Signal-induced proliferation-associated 1-like protein 1
Gene Name	Sipa1l1
Organism	Rattus norvegicus (Rat).
Sequence Length	1822
Subcellular Localization	Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse, synaptosome. Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons.
Protein Description	Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis..
Protein Sequence	MTSLKRSQTERPVTADRASVVSTDGTPKVHTDDFYMRRFRSQNGSLGSSVMAAVGPPRSEGPHHITSTPGVPKMGVRARIADWPPRKENVKESSRSSQEIETSSCLESLSSKGSPVSQGSSVSLNSNDSAMLKSIQNTLKNKTGPAESMDSRFLMPEAYPSSPRKALRRIRQRSNSDITISELDVDSFDECISPTYKSGPSLHREYGSTSSIDKQGTSGESFFGLLKGYKDDRADRGPTPTKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSTSFSSPMGSTEDFNSKGSLGMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESTSFESALSSHCTNAGVAVLEVPKESLMLHLDRVRRYTVEHVDLGAYYYRKCFYQKEHWNYFGADENLGPVAVSIRREKPEDMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVIPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNTPKVTEQFMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVRAHNPCTESVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMGAIVWAVRAKDYNKAMEFDCLLGISNEFIVLIEQETKSVVFNCSCRDVIGWTSSDSSLKIFYERGECISVESFMSSEDIKEIVKRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEGIVADVEPYGYAWQAGLKQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDDCTPRRSCSETYRMPVMEYKMNEGVSYEYKFPFRSNNKWQRNAGKGAHSPQVPLQLQSPMISRVNAGKGDGKMPLPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMALARSQCRNSPSNLSSSSETGSGGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDIGGSGKSTPSWQRSEDSLADQMEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESDLNSYNYLQGTSADSGIDTASYGLSHGSTASLGASTSSPRSGPGKEKVAPLWHSSSEVLSLADRTLETEGHGMDRKTESSLSLDIHSKSQGGSSPLTRENSTFSINDATSHTSTMSSRHSASPVVFSSARSSPKEELHPTTSSQLAPSFSSSSSSSSGPRTFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEIAHTRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESPTPESQKNFKFHGLSSPQSPFPSTPTSRRALHRTLSDESIYSSQREHFFTSRASLLDQALPNDVFFSSTYPSLPKSLPLRRPSYTLGMKSLHGEFFASDSSLTDIQETRRQPIPDPGLMPLPDTASDLDWSNLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEEQALVQMKSYSSSKDSSPTLASKVDQLEGMLKMLREDLKKEKEDKAHLQAEVEHLREDNLRLQEESQNASDKLKKFTEWVFNTIDMS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
93	Phosphorylation	RKENVKESSRSSQEI CHHCCCCCCCCCCHH	25.90	28689409
94	Phosphorylation	KENVKESSRSSQEIE HHCCCCCCCCCCHHH	36.95	28689409
96	Phosphorylation	NVKESSRSSQEIETS CCCCCCCCCCHHHHH	38.02	28689409
97	Phosphorylation	VKESSRSSQEIETSS CCCCCCCCCHHHHHH	30.62	28689409
108	Phosphorylation	ETSSCLESLSSKGSP HHHHHHHHHHCCCCC	22.17	30181290
110	Phosphorylation	SSCLESLSSKGSPVS HHHHHHHHCCCCCCC	39.00	30181290
111	Phosphorylation	SCLESLSSKGSPVSQ HHHHHHHCCCCCCCC	46.45	30181290
114	Phosphorylation	ESLSSKGSPVSQGSS HHHHCCCCCCCCCCC	26.35	21630457
117	Phosphorylation	SSKGSPVSQGSSVSL HCCCCCCCCCCCEEC	32.01	21630457
120	Phosphorylation	GSPVSQGSSVSLNSN CCCCCCCCCEECCCC	21.67	21630457
159	Phosphorylation	RFLMPEAYPSSPRKA HHCCCCCCCCCHHHH	11.28	25575281
161	Phosphorylation	LMPEAYPSSPRKALR CCCCCCCCCHHHHHH	40.05	22108457
162	Phosphorylation	MPEAYPSSPRKALRR CCCCCCCCHHHHHHH	24.99	22108457
187	Phosphorylation	ISELDVDSFDECISP EEEECCCCCHHHCCC	34.15	-
193	Phosphorylation	DSFDECISPTYKSGP CCCHHHCCCCCCCCC	23.89	-
206	Phosphorylation	GPSLHREYGSTSSID CCCCCCHHCCCCCCC	19.14	22673903
208	Phosphorylation	SLHREYGSTSSIDKQ CCCCHHCCCCCCCCC	24.98	29779826
209	Phosphorylation	LHREYGSTSSIDKQG CCCHHCCCCCCCCCC	23.33	22673903
210	Phosphorylation	HREYGSTSSIDKQGT CCHHCCCCCCCCCCC	27.30	22673903
211	Phosphorylation	REYGSTSSIDKQGTS CHHCCCCCCCCCCCC	34.59	22673903
217	Phosphorylation	SSIDKQGTSGESFFG CCCCCCCCCCCCHHH	30.94	28689409
221	Phosphorylation	KQGTSGESFFGLLKG CCCCCCCCHHHHHHC	29.42	28689409
239	Phosphorylation	DRADRGPTPTKLSDF CCCCCCCCCCCHHHE	46.55	29779826
244	Phosphorylation	GPTPTKLSDFLITGG CCCCCCHHHEEECCC	28.07	23984901
249	Phosphorylation	KLSDFLITGGGKGSG CHHHEEECCCCCCCC	31.74	23984901
255	Phosphorylation	ITGGGKGSGFSLDVI ECCCCCCCCCCEEEC	39.90	27097102
258	Phosphorylation	GGKGSGFSLDVIDGP CCCCCCCCEEECCCC	27.47	23984901
286	Phosphorylation	EKPLKRRSKSETGDS CCCCCCCCCCCCCCH	44.56	27097102
288	Phosphorylation	PLKRRSKSETGDSSI CCCCCCCCCCCCHHH	41.45	27097102
290	Phosphorylation	KRRSKSETGDSSIFR CCCCCCCCCCHHHHH	54.07	27097102
293	Phosphorylation	SKSETGDSSIFRKLR CCCCCCCHHHHHHHH	27.03	27097102
310	Phosphorylation	KGEELGKSSDLEDNR CCHHCCCCCCCCCCC	27.56	28432305
311	Phosphorylation	GEELGKSSDLEDNRS CHHCCCCCCCCCCCC	50.10	28432305
318	Phosphorylation	SDLEDNRSEDSVRPW CCCCCCCCCCCCCCC	52.59	25575281
321	Phosphorylation	EDNRSEDSVRPWTCP CCCCCCCCCCCCCCC	18.90	25575281
326	Phosphorylation	EDSVRPWTCPKCFAH CCCCCCCCCCCHHCC	22.93	30181290
559	Phosphorylation	LEDAIPSTAKHSTAR HHHHCCCCCCCCCCC	34.08	22668510
563	Phosphorylation	IPSTAKHSTARGLPL CCCCCCCCCCCCCCH	24.05	22668510
839	Acetylation	NAAHKSEKFRAMATR HHHHHHHHHHHHHHH	47.44	22902405
964	Phosphorylation	YERGECISVESFMSS EECCCEEEHHHCCCH	31.33	25575281
967	Phosphorylation	GECISVESFMSSEDI CCEEEHHHCCCHHHH	24.88	25575281
970	Phosphorylation	ISVESFMSSEDIKEI EEHHHCCCHHHHHHH	28.68	25575281
971	Phosphorylation	SVESFMSSEDIKEIV EHHHCCCHHHHHHHH	27.74	25575281
1117	Phosphorylation	NAGKGAHSPQVPLQL CCCCCCCCCCCCCEE	19.25	-
1126	Phosphorylation	QVPLQLQSPMISRVN CCCCEECCCCCCCCC	25.65	-
1153	Phosphorylation	RAANIPRSISSDGRP HHHCCCCCCCCCCCC	22.82	27097102
1155	Phosphorylation	ANIPRSISSDGRPLE HCCCCCCCCCCCCCC	24.51	27097102
1156	Phosphorylation	NIPRSISSDGRPLER CCCCCCCCCCCCCCC	42.27	25403869
1166	Phosphorylation	RPLERRLSPGSDIYV CCCCCCCCCCCCEEE	25.96	23984901
1169	Phosphorylation	ERRLSPGSDIYVTVS CCCCCCCCCEEEEHH	24.99	23984901
1172	Phosphorylation	LSPGSDIYVTVSSMA CCCCCCEEEEHHHHH	8.61	23984901
1174	Phosphorylation	PGSDIYVTVSSMALA CCCCEEEEHHHHHHH	9.56	23984901
1188	Phosphorylation	ARSQCRNSPSNLSSS HHHHHCCCCCCCCCC	15.45	28432305
1190	Phosphorylation	SQCRNSPSNLSSSSE HHHCCCCCCCCCCCC	50.66	28432305
1193	Phosphorylation	RNSPSNLSSSSETGS CCCCCCCCCCCCCCC	32.21	27097102
1194	Phosphorylation	NSPSNLSSSSETGSG CCCCCCCCCCCCCCC	40.84	27097102
1195	Phosphorylation	SPSNLSSSSETGSGG CCCCCCCCCCCCCCC	28.90	27097102
1196	Phosphorylation	PSNLSSSSETGSGGG CCCCCCCCCCCCCCC	40.92	27097102
1198	Phosphorylation	NLSSSSETGSGGGTY CCCCCCCCCCCCCCC	38.30	27097102
1209	Phosphorylation	GGTYRQKSMPEGFGV CCCCCCCCCCCCCCC	31.09	27097102
1220	Phosphorylation	GFGVSRRSPASIDRQ CCCCCCCCCHHCCCC	24.57	29779826
1273	Phosphorylation	VLPAFRESPSGRLMR HHHHHHHCCCCCCCC	21.80	29779826
1275	Phosphorylation	PAFRESPSGRLMRQD HHHHHCCCCCCCCCC	45.91	28432305
1288	Phosphorylation	QDPVVHLSPNKQGHS CCCEEECCCCCCCCC	16.14	27097102
1327	Phosphorylation	KWYDGDRTESDLNSY CCCCCCCCHHHHHHC	44.58	28689409
1333	Phosphorylation	RTESDLNSYNYLQGT CCHHHHHHCCHHCCC	23.27	28689409
1340	Phosphorylation	SYNYLQGTSADSGID HCCHHCCCCCCCCCC	14.05	28689409
1344	Phosphorylation	LQGTSADSGIDTASY HCCCCCCCCCCCHHH	37.05	18723513
1348	Phosphorylation	SADSGIDTASYGLSH CCCCCCCCHHHCCCC	18.64	18723513
1366	Phosphorylation	ASLGASTSSPRSGPG CCCCCCCCCCCCCCC	35.53	28689409
1367	Phosphorylation	SLGASTSSPRSGPGK CCCCCCCCCCCCCCC	25.15	22817900
1383	Phosphorylation	KVAPLWHSSSEVLSL CCCCCCCCHHHHHHH	24.79	27097102
1384	Phosphorylation	VAPLWHSSSEVLSLA CCCCCCCHHHHHHHH	20.03	27097102
1385	Phosphorylation	APLWHSSSEVLSLAD CCCCCCHHHHHHHHH	34.44	27097102
1389	Phosphorylation	HSSSEVLSLADRTLE CCHHHHHHHHHHCHH	27.04	28432305
1406	Phosphorylation	GHGMDRKTESSLSLD CCCCCCCCCCEEEEE	41.83	30181290
1408	Phosphorylation	GMDRKTESSLSLDIH CCCCCCCCEEEEEEE	41.64	25575281
1409	Phosphorylation	MDRKTESSLSLDIHS CCCCCCCEEEEEEEC	18.75	25575281
1411	Phosphorylation	RKTESSLSLDIHSKS CCCCCEEEEEEECCC	26.41	25575281
1416	Phosphorylation	SLSLDIHSKSQGGSS EEEEEEECCCCCCCC	34.04	30181290
1418	Phosphorylation	SLDIHSKSQGGSSPL EEEEECCCCCCCCCC	36.75	28432305
1422	Phosphorylation	HSKSQGGSSPLTREN ECCCCCCCCCCCCCC	35.29	28432305
1423	Phosphorylation	SKSQGGSSPLTRENS CCCCCCCCCCCCCCC	27.49	22108457
1426	Phosphorylation	QGGSSPLTRENSTFS CCCCCCCCCCCCCEE	39.04	28432305
1430	Phosphorylation	SPLTRENSTFSINDA CCCCCCCCCEECCCC	26.52	30181290
1431	Phosphorylation	PLTRENSTFSINDAT CCCCCCCCEECCCCC	32.74	30181290
1433	Phosphorylation	TRENSTFSINDATSH CCCCCCEECCCCCCC	22.14	30181290
1438	Phosphorylation	TFSINDATSHTSTMS CEECCCCCCCCCCCC	24.73	30181290
1449	Phosphorylation	STMSSRHSASPVVFS CCCCCCCCCCCEEEE	29.36	27097102
1451	Phosphorylation	MSSRHSASPVVFSSA CCCCCCCCCEEEECC	22.65	27097102
1456	Phosphorylation	SASPVVFSSARSSPK CCCCEEEECCCCCCC	16.10	27097102
1457	Phosphorylation	ASPVVFSSARSSPKE CCCEEEECCCCCCCH	19.08	27097102
1460	Phosphorylation	VVFSSARSSPKEELH EEEECCCCCCCHHCC	51.19	28689409
1461	Phosphorylation	VFSSARSSPKEELHP EEECCCCCCCHHCCC	34.14	22668510
1469	Phosphorylation	PKEELHPTTSSQLAP CCHHCCCCCHHHCCC	28.67	25575281
1470	Phosphorylation	KEELHPTTSSQLAPS CHHCCCCCHHHCCCC	30.72	28689409
1471	Phosphorylation	EELHPTTSSQLAPSF HHCCCCCHHHCCCCC	20.68	25575281
1472	Phosphorylation	ELHPTTSSQLAPSFS HCCCCCHHHCCCCCC	27.41	25575281
1477	Phosphorylation	TSSQLAPSFSSSSSS CHHHCCCCCCCCCCC	31.96	25575281
1479	Phosphorylation	SQLAPSFSSSSSSSS HHCCCCCCCCCCCCC	33.38	25575281
1480	Phosphorylation	QLAPSFSSSSSSSSG HCCCCCCCCCCCCCC	32.03	28689409
1481	Phosphorylation	LAPSFSSSSSSSSGP CCCCCCCCCCCCCCC	32.80	25575281
1482	Phosphorylation	APSFSSSSSSSSGPR CCCCCCCCCCCCCCC	35.87	30181290
1483	Phosphorylation	PSFSSSSSSSSGPRT CCCCCCCCCCCCCCC	35.87	30181290
1484	Phosphorylation	SFSSSSSSSSGPRTF CCCCCCCCCCCCCCC	30.39	30181290
1485	Phosphorylation	FSSSSSSSSGPRTFY CCCCCCCCCCCCCCC	41.06	30181290
1486	Phosphorylation	SSSSSSSSGPRTFYP CCCCCCCCCCCCCCC	55.56	30181290
1526	Phosphorylation	DTRKRHQSDGNEIAH CCCHHCCCCCCHHHH	41.16	28432305
1546	Phosphorylation	STRDLRASPKPTSKS HHCCHHCCCCCCCCC	27.33	29779826
1550	Phosphorylation	LRASPKPTSKSTIEE HHCCCCCCCCCHHHH	55.71	25575281
1551	Phosphorylation	RASPKPTSKSTIEED HCCCCCCCCCHHHHH	32.89	25575281
1553	Phosphorylation	SPKPTSKSTIEEDLK CCCCCCCCHHHHHHH	34.09	26022182
1567	Phosphorylation	KKLIDLESPTPESQK HHHHCCCCCCHHHHC	41.17	23712012
1569	Phosphorylation	LIDLESPTPESQKNF HHCCCCCCHHHHCCC	49.30	25403869
1572	Phosphorylation	LESPTPESQKNFKFH CCCCCHHHHCCCEEC	47.89	25403869
1582	Phosphorylation	NFKFHGLSSPQSPFP CCEECCCCCCCCCCC	44.56	27097102
1583	Phosphorylation	FKFHGLSSPQSPFPS CEECCCCCCCCCCCC	31.81	27097102
1586	Phosphorylation	HGLSSPQSPFPSTPT CCCCCCCCCCCCCCC	31.71	27097102
1590	Phosphorylation	SPQSPFPSTPTSRRA CCCCCCCCCCCHHHH	47.61	28432305
1591	Phosphorylation	PQSPFPSTPTSRRAL CCCCCCCCCCHHHHH	30.72	27097102
1593	Phosphorylation	SPFPSTPTSRRALHR CCCCCCCCHHHHHHH	34.65	27097102
1594	Phosphorylation	PFPSTPTSRRALHRT CCCCCCCHHHHHHHH	22.44	27097102
1601	Phosphorylation	SRRALHRTLSDESIY HHHHHHHHCCCHHHH	21.62	27097102
1603	Phosphorylation	RALHRTLSDESIYSS HHHHHHCCCHHHHHH	38.42	23712012
1606	Phosphorylation	HRTLSDESIYSSQRE HHHCCCHHHHHHHHH	31.64	27097102
1608	Phosphorylation	TLSDESIYSSQREHF HCCCHHHHHHHHHHH	16.14	28689409
1609	Phosphorylation	LSDESIYSSQREHFF CCCHHHHHHHHHHHH	20.51	28689409
1610	Phosphorylation	SDESIYSSQREHFFT CCHHHHHHHHHHHHH	19.11	28689409
1619	Asymmetric dimethylarginine	REHFFTSRASLLDQA HHHHHHCHHHHHHHH	25.74	-
1619	Methylation	REHFFTSRASLLDQA HHHHHHCHHHHHHHH	25.74	-
1621	Phosphorylation	HFFTSRASLLDQALP HHHHCHHHHHHHHCC	28.49	-
1650	Phosphorylation	SLPLRRPSYTLGMKS CCCCCCCCEECCCHH	29.01	28432305
1651	Phosphorylation	LPLRRPSYTLGMKSL CCCCCCCEECCCHHH	14.52	25403869
1652	Phosphorylation	PLRRPSYTLGMKSLH CCCCCCEECCCHHHC	22.60	28432305
1665	Phosphorylation	LHGEFFASDSSLTDI HCCCCCCCCCCCCCH	32.63	-
1668	Phosphorylation	EFFASDSSLTDIQET CCCCCCCCCCCHHHH	40.03	-
1713	Phosphorylation	AYEVQRASFFAASDE HHHHHHHHHEECCCC	24.08	28689409
1718	Phosphorylation	RASFFAASDENHRPL HHHHEECCCCCCCCC	41.87	28689409
1726	Phosphorylation	DENHRPLSAASNSDQ CCCCCCCCCCCCCHH	25.19	28689409
1729	Phosphorylation	HRPLSAASNSDQLEE CCCCCCCCCCHHHHH	36.26	28689409
1731	Phosphorylation	PLSAASNSDQLEEQA CCCCCCCCHHHHHHH	25.00	28689409
1746	Phosphorylation	LVQMKSYSSSKDSSP HHHHHHHCCCCCCCH	34.91	-
1747	Phosphorylation	VQMKSYSSSKDSSPT HHHHHHCCCCCCCHH	32.92	-
1751	Phosphorylation	SYSSSKDSSPTLASK HHCCCCCCCHHHHHH	41.79	28432305
1752	Phosphorylation	YSSSKDSSPTLASKV HCCCCCCCHHHHHHH	31.85	22108457
1754	Phosphorylation	SSKDSSPTLASKVDQ CCCCCCHHHHHHHHH	36.58	28432305
1757	Phosphorylation	DSSPTLASKVDQLEG CCCHHHHHHHHHHHH	36.00	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1344	S	Phosphorylation	Kinase	PLK2	Q9R012	Uniprot
1348	T	Phosphorylation	Kinase	PLK2	Q9R012	Uniprot
1367	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
1367	S	Phosphorylation	Kinase	CDK5	Q03114	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1367	S	Phosphorylation		18498738
Phosphorylated at Ser-1367 by CDK5, creating a docking site for the POLO box domains of PLK2.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SI1L1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
UBC_RAT	Ubc	physical	23850969

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SI1L1_RAT

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Critical role of CDK5 and Polo-like kinase 2 in homeostatic synapticplasticity during elevated activity."; Seeburg D.P., Feliu-Mojer M., Gaiottino J., Pak D.T., Sheng M.; Neuron 58:571-583(2008). Cited for: PHOSPHORYLATION AT SER-1367, UBIQUITINATION, AND MUTAGENESIS OFSER-1367.	18498738 [Abstract]
"Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and theSCFbeta-TRCP ubiquitin ligase in hippocampal neurons."; Ang X.L., Seeburg D.P., Sheng M., Harper J.W.; J. Biol. Chem. 283:29424-29432(2008). Cited for: PHOSPHORYLATION AT SER-1344 AND THR-1348, UBIQUITINATION, ANDMUTAGENESIS OF SER-1344 AND THR-1348.	18723513 [Abstract]

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