SHRM1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHRM1_MOUSE
• UniProt AC: Q5SX79
• Protein Name: Protein Shroom1
• Gene Name: Shroom1
• Organism: Mus musculus (Mouse).
• Sequence Length: 823
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: May be involved in the assembly of microtubule arrays during cell elongation..
• Protein Sequence: MEALGTGRDRTSQASATESLDLRRLSTRADSAYSSFSTASGDPETRTPSPGTERLPYLDWDYVRVVWGSQSPTSKDAVLSTTQRPVQAVAGHSDPRSPEVQGSPGPLNRQDTPLLYALAAEAEATAHTAEPPSPPASRDAYRQRLQGAQRRVLRETSFQRKEFRMSLPGRLRPAVPTRLPTAHVRSASSSQELGEEEPARTAVPALAAAGRGRLSSQQRQCCFSEPGKLHRVGWSGGPTGEDLRKDYSTQELQRGMHAKSKGLLETQSLSSTELNSGPADLGNAHRPAGRSQSVSGEVMGPCKGSERTVATVQAVPQRADIRRPLLHTKLSRSLTQKEVTGVCPGEALQTKPAGCGRRISETSVSTPGPSLPEDDVFLREAKTPSPQDSQGLPTSTSYRQYENDLSKKAGQIAVSAERPLHETPGITGTEDCGQAVNGSVDLSRPTSIPETTNDDIPTFDTNGTTDPSAATEKKPLKPPPVDVLRPSDSETPGSPHHTSLTWGQFDSKTTWPSRHFEALVQELARLDPSLSRTLAAQPGPEPPQGLLDGLFPVEEIRSAMRPALEEMGEKAAGASEEGSCGHHLTQDLQTSQEASRSENSTPDPDQSSGQEFPEGNSTQAKKVELARLLQKMLQDLHAEQERLRGTAADWTQRNGALEAAVSQACTPRELERFRRFMTDLERVLGLLLLLGSRLVRVNLALARAGSNSDPDERASLLQRLQLLQRQQEEAKELKEHVARREQTLRQVLERELPAEHLRSYCVLLASKARILSQQRSLDDRIRFLKDQLDTIWSDLSHHPLSPRLTWAPAIRPLNKQPFLATLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEALGTGR -------CCCCCCCC	6.49	-
11	Phosphorylation	LGTGRDRTSQASATE CCCCCCCCCCCCHHH	29.49	21743459
12	Phosphorylation	GTGRDRTSQASATES CCCCCCCCCCCHHHH	25.33	21743459
15	Phosphorylation	RDRTSQASATESLDL CCCCCCCCHHHHHHH	28.25	21743459
17	Phosphorylation	RTSQASATESLDLRR CCCCCCHHHHHHHHH	24.50	21743459
19	Phosphorylation	SQASATESLDLRRLS CCCCHHHHHHHHHHH	23.87	21743459
37	Phosphorylation	DSAYSSFSTASGDPE HHHHHHCCCCCCCCC	25.63	29472430
38	Phosphorylation	SAYSSFSTASGDPET HHHHHCCCCCCCCCC	23.88	29472430
40	Phosphorylation	YSSFSTASGDPETRT HHHCCCCCCCCCCCC	43.76	29472430
45	Phosphorylation	TASGDPETRTPSPGT CCCCCCCCCCCCCCC	45.27	25521595
47	Phosphorylation	SGDPETRTPSPGTER CCCCCCCCCCCCCCC	35.22	29472430
49	Phosphorylation	DPETRTPSPGTERLP CCCCCCCCCCCCCCC	35.04	25521595
52	Phosphorylation	TRTPSPGTERLPYLD CCCCCCCCCCCCCCC	22.70	29472430
69	Phosphorylation	YVRVVWGSQSPTSKD EEEEEECCCCCCCHH	16.27	26643407
71	Phosphorylation	RVVWGSQSPTSKDAV EEEECCCCCCCHHHH	31.66	25521595
73	Phosphorylation	VWGSQSPTSKDAVLS EECCCCCCCHHHHHH	54.37	26643407
74	Phosphorylation	WGSQSPTSKDAVLST ECCCCCCCHHHHHHC	31.74	26643407
74	O-linked_Glycosylation	WGSQSPTSKDAVLST ECCCCCCCHHHHHHC	31.74	30059200
97	Phosphorylation	AGHSDPRSPEVQGSP CCCCCCCCCCCCCCC	30.70	25619855
103	Phosphorylation	RSPEVQGSPGPLNRQ CCCCCCCCCCCCCCC	15.02	25521595
112	Phosphorylation	GPLNRQDTPLLYALA CCCCCCCCHHHHHHH	13.90	20469934
116	Phosphorylation	RQDTPLLYALAAEAE CCCCHHHHHHHHHHH	13.78	20469934
125	Phosphorylation	LAAEAEATAHTAEPP HHHHHHHHCCCCCCC	15.52	23984901
128	Phosphorylation	EAEATAHTAEPPSPP HHHHHCCCCCCCCCC	30.19	23984901
133	Phosphorylation	AHTAEPPSPPASRDA CCCCCCCCCCCCHHH	54.98	27180971
137	Phosphorylation	EPPSPPASRDAYRQR CCCCCCCCHHHHHHH	36.15	23984901
157	Phosphorylation	RRVLRETSFQRKEFR HHHHHHHHCCCCCHH	18.03	29514104
166	Phosphorylation	QRKEFRMSLPGRLRP CCCCHHHCCCCCCCC	27.44	26824392
186	Phosphorylation	LPTAHVRSASSSQEL CCCHHCCCCCCCCCC	31.26	25619855
188	Phosphorylation	TAHVRSASSSQELGE CHHCCCCCCCCCCCC	31.59	25521595
189	Phosphorylation	AHVRSASSSQELGEE HHCCCCCCCCCCCCC	35.44	25619855
190	Phosphorylation	HVRSASSSQELGEEE HCCCCCCCCCCCCCC	25.77	25619855
215	Phosphorylation	AAGRGRLSSQQRQCC HCCCCCCCHHHHCHH	25.41	24719451
216	Phosphorylation	AGRGRLSSQQRQCCF CCCCCCCHHHHCHHC	34.62	24719451
224	Phosphorylation	QQRQCCFSEPGKLHR HHHCHHCCCCCCCEE	29.03	25521595
266	Phosphorylation	KSKGLLETQSLSSTE HHCCCCCCCCCCCCC	24.35	23984901
268	Phosphorylation	KGLLETQSLSSTELN CCCCCCCCCCCCCCC	37.32	26643407
270	Phosphorylation	LLETQSLSSTELNSG CCCCCCCCCCCCCCC	40.22	30352176
271	Phosphorylation	LETQSLSSTELNSGP CCCCCCCCCCCCCCC	31.06	26643407
272	Phosphorylation	ETQSLSSTELNSGPA CCCCCCCCCCCCCCC	40.91	26643407
276	Phosphorylation	LSSTELNSGPADLGN CCCCCCCCCCCCCCC	59.80	29472430
291	Phosphorylation	AHRPAGRSQSVSGEV CCCCCCCCCCCCCCE	26.37	25521595
293	Phosphorylation	RPAGRSQSVSGEVMG CCCCCCCCCCCCEEC	21.35	25521595
295	Phosphorylation	AGRSQSVSGEVMGPC CCCCCCCCCCEECCC	34.19	25521595
331	Phosphorylation	PLLHTKLSRSLTQKE HHHHHHHCCCCCCCC	22.75	29514104
360	Phosphorylation	AGCGRRISETSVSTP CCCCCCCCCCCCCCC	32.77	30352176
362	Phosphorylation	CGRRISETSVSTPGP CCCCCCCCCCCCCCC	27.86	29472430
363	Phosphorylation	GRRISETSVSTPGPS CCCCCCCCCCCCCCC	15.26	23984901
365	Phosphorylation	RISETSVSTPGPSLP CCCCCCCCCCCCCCC	28.75	23984901
366	Phosphorylation	ISETSVSTPGPSLPE CCCCCCCCCCCCCCC	30.06	23984901
383	Phosphorylation	VFLREAKTPSPQDSQ EEEEECCCCCCCCCC	35.73	25521595
385	Phosphorylation	LREAKTPSPQDSQGL EEECCCCCCCCCCCC	40.19	25521595
389	Phosphorylation	KTPSPQDSQGLPTST CCCCCCCCCCCCCCC	22.39	29472430
487	Phosphorylation	PVDVLRPSDSETPGS CCCCCCCCCCCCCCC	47.54	21183079
489	Phosphorylation	DVLRPSDSETPGSPH CCCCCCCCCCCCCCC	47.94	21183079
499	Phosphorylation	PGSPHHTSLTWGQFD CCCCCCCCCCCCCCC	21.31	21183079
501	Phosphorylation	SPHHTSLTWGQFDSK CCCCCCCCCCCCCCC	27.58	21183079
772	Phosphorylation	ASKARILSQQRSLDD HHHHHHHHHCCCHHH	23.15	24719451
790	Phosphorylation	FLKDQLDTIWSDLSH HHHHHHHHHHHHHCC	32.70	23984901
793	Phosphorylation	DQLDTIWSDLSHHPL HHHHHHHHHHCCCCC	25.48	23984901
796	Phosphorylation	DTIWSDLSHHPLSPR HHHHHHHCCCCCCCC	25.41	23984901
801	Phosphorylation	DLSHHPLSPRLTWAP HHCCCCCCCCCCCCC	16.66	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SHRM1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHRM1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHRM1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SHRM1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188; SER-293; THR-383AND SER-385, AND MASS SPECTROMETRY.
PubMed: 17242355