SHPRH_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHPRH_MOUSE
• UniProt AC: Q7TPQ3
• Protein Name: E3 ubiquitin-protein ligase SHPRH
• Gene Name: Shprh
• Organism: Mus musculus (Mouse).
• Sequence Length: 1674
• Protein Description: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'..
• Protein Sequence: MSSRRKRAPPMKVDEERQQQLHWNMHEDLRSEPLTMTVGEQACSDADSSSDCIIIDEGPPESALHRDKKRRSETVSVLEATEEETRLSVTLNVTVSPYRVDNSWKAFLGDFALQLLPKESLVEHFSERTFTLSPSESSSQFLIYVHSECKNVEKQENVLEGSAGVCSKGIRVESSFSSDMLQDLAWLQKRRGIKLYQRPDGTHTIKVGIYILEAGLTRLDFMSDAGSRMKKFNQLMKRVMEKLHNFIIPDVLEEEEEGSESEPEGQDIDELYHFVKQTHQQETRSVQVDVQHPALIPVLRPYQREAVNWMLQQEQFRSAPPADNSLHFLWREIVTPDGLKLYYNPYTGCIIRDFPHAGPQLLGGILADEMGLGKTVEVLALILTHTRQDVKQDALTLPEGKVVNYFIPTHCPREKVKNREIQDTEYEPKEKVHCPPTRVMILTAVKEMNGKKGVSILSIYKYVSSIFRYDVQRNRGLLKRMLKCLIFEGLVKQIKGHGFSGTFTLGKNYKEDVFDKTKKQAVGSPRKIEKELRKSVNKDADSEYLPSNTSDDDEPYYYYCKAGKSRSKLKKPALLTKKGKGQSVHLDSQGDAPAAGVCASTDVHVSENTCVSEDKQTQEAKDCAESPNPAAEELAQSNTSSPCETSDYRFECICGEFDQIGHKPRVQCLKCHLWQHAKCVNYEEKNLKVKPFYCPHCLVAMEPVSTRATLIISPSSICHQWVDEINRHVRSSSLRVLVYQGVKKHGFLQPHFLAEQDIVIITYDVLRSELNYVNIPHSNSEDGRRLRNQKRYMAIPSPLVAVEWWRICLDEAQMVECPTVKAAEMAQRLSGINRWCISGTPVQRGLEDLFGLVVFLGIEPYCVKHWWIRLLYHPYCKKNPQHLYSFIAKIMWRSAKKDVIDQIQIPPQTEEMHWLHFSPVERHFYHRQHEVCCQDAIVKLRKISDWALKLSSLDRRTVSSILYPLLRLRQACCHPQAVRGEFLPLQKSTMTMEELLTSLQKKCGTECEEAHRQLVCALNGLAGIHIIKGEYALAAELYREVLRSSEEHKGKLKTDSLQRLHATHNLMELLGAKHPGIPPTLRDGRLEEEAKQLREHYMSKCNTEVAEAQQALQPVQQSIRELQRKIHSNSPWWLNVIHRAMEFSVDEELVQRVRNEISSNYKQQTDKLSMSEKFRDCRGLQFLLTTQMEELHKFQKLVREAVKKLEKPPSREVIESATVCHLRPARLPLNCCVFCKADELFTEYESKLFFNTVKGQTAIFEEMIEDEEGLVDDRVPTTTRGLWAVSETERSMKAILSFARSHRFDVEYVDEGSVSMDLFEAWKKEYKLLHEYWMTLRNRVSAVDELAMATERLRVRHPKEPKPNPPVHHIIEPHEVEQNRIKLVNDKAVATSQLQKKLGQLLYLTNLEKSQDKTSGGINPEPCPICARQLGKQWAVLTCGHCFCNECTSIIIEQYSVGSHRSSIKCAICRQTTSHKEVSYVFTSEKANQEDDIPVKGSHSTKVEAVVRTLMKIQLRDPGAKALVFSTWQDVLDIISKALTDNNMEFTQISRIKTFQENLSAFKYDPHINILLLPLHTGSNGLTIIEATHVLLVEPILNPAHELQAIGRVHRIGQTKPTIVHRFLIKATIEERMQAMLKTAERSHTSSSGKHSEASVLTVAGLADLFTKENEELE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	HRDKKRRSETVSVLE CCCHHCHHCCEEEEE	41.47	28833060
74	Phosphorylation	DKKRRSETVSVLEAT CHHCHHCCEEEEEEC	21.23	28833060
88	Phosphorylation	TEEETRLSVTLNVTV CCCCEEEEEEEEEEE	15.12	25777480
90	Phosphorylation	EETRLSVTLNVTVSP CCEEEEEEEEEEECC	14.83	25777480
98	Phosphorylation	LNVTVSPYRVDNSWK EEEEECCEEECCCHH	18.76	25777480
259	Phosphorylation	LEEEEEGSESEPEGQ HCHHHCCCCCCCCCC	41.03	26643407
261	Phosphorylation	EEEEGSESEPEGQDI HHHCCCCCCCCCCCH	61.21	26643407
272	Phosphorylation	GQDIDELYHFVKQTH CCCHHHHHHHHHHHH	7.37	26643407
346	Phosphorylation	LKLYYNPYTGCIIRD CEEEECCCCCEEECC	16.48	-
347	Phosphorylation	KLYYNPYTGCIIRDF EEEECCCCCEEECCC	27.17	-
443	Phosphorylation	PTRVMILTAVKEMNG CCEEEEEEEHHHHCC	20.62	25159016
518	Acetylation	EDVFDKTKKQAVGSP HHCCHHHHHHHCCCH	48.94	22902405
524	Phosphorylation	TKKQAVGSPRKIEKE HHHHHCCCHHHHHHH	18.22	23684622
547	Phosphorylation	ADSEYLPSNTSDDDE CCCCCCCCCCCCCCC	50.58	26745281
549	Phosphorylation	SEYLPSNTSDDDEPY CCCCCCCCCCCCCCC	37.56	21149613
550	Phosphorylation	EYLPSNTSDDDEPYY CCCCCCCCCCCCCCE	43.20	21149613
556	Phosphorylation	TSDDDEPYYYYCKAG CCCCCCCCEEECCCC	11.31	26745281
557	Phosphorylation	SDDDEPYYYYCKAGK CCCCCCCEEECCCCC	9.93	29899451
626	Phosphorylation	EAKDCAESPNPAAEE HHHHHHCCCCHHHHH	16.08	25521595
731	Phosphorylation	EINRHVRSSSLRVLV HHHHHHHHCCCEEEE	24.16	26026062
732	Phosphorylation	INRHVRSSSLRVLVY HHHHHHHCCCEEEEE	23.87	26026062
739	Phosphorylation	SSLRVLVYQGVKKHG CCCEEEEECCHHHHC	8.73	26026062
778	Phosphorylation	NYVNIPHSNSEDGRR CCCCCCCCCCCCCHH	36.38	30635358
780	Phosphorylation	VNIPHSNSEDGRRLR CCCCCCCCCCCHHHH	39.83	30635358
1158	Phosphorylation	QRVRNEISSNYKQQT HHHHHHHHHCHHHHH	13.32	22871156
1350	Phosphorylation	VDELAMATERLRVRH HHHHHHHHHHHHCCC	14.46	28285833
1553	Ubiquitination	FTQISRIKTFQENLS HHHHHHHHHHHHHHH	42.02	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SHPRH_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHPRH_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHPRH_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
POLK_HUMAN	POLK	physical	21396873
POLH_HUMAN	POLH	physical	21396873
RAD18_HUMAN	RAD18	physical	21396873
HLTF_HUMAN	HLTF	physical	21396873

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.