dbPTM

SHP1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SHP1L_HUMAN
UniProt AC	Q9BZQ2
Protein Name	Testicular spindle-associated protein SHCBP1L {ECO:0000305}
Gene Name	SHCBP1L {ECO:0000312\|HGNC:HGNC:16788}
Organism	Homo sapiens (Human).
Sequence Length	653
Subcellular Localization	Cytoplasm, cytoskeleton, spindle . Colocalizes with alpha tubulin during meiosis. Colocalizes with HSPA2 at spindle during the meiosis process.
Protein Description	Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells..
Protein Sequence	MASGSKASVPADSFRTISPDRRGEKSASAVSGDTAAATTLKGTAIPVRSVVASPRPVKGKAGRETARLRLQRLPAAQAEDTGEAAAAAAEEPLLPVPEDEEEAQPLPPVCVSRMRGMWRDEKVSLYCDEVLQDCKAEDADEVMGKYLSEKLKLKDKWLGVWKTNPSVFFVKYEEASIPFVGILVEVTCEPYQDSSSRFKVTVSVAEPFSSNIANIPRDLVDEILEELEHSVPLLEVYPVEGQDTDIHVIALALEVVRFFYDFLWRDWDDEESCENYTALIEERINLWCDIQDGTIPGPIAQRFKKTLEKYKNKRVELIEYQSNIKEDPSAAEAVECWKKYYEIVMLCGLLKMWEDLRLRVHGPFFPRILRRRKGKREFGKTITHIVAKMMTTEMIKDLSSDTLLQQHGDLDLALDNCYSGDTVIIFPGEYQAANLALLTDDIIIKGVGKREEIMITSEPSRDSFVVSKADNVKLMHLSLIQQGTVDGIVVVESGHMTLENCILKCEGTGVCVLTGAALTITDSEITGAQGAGVELYPGSIAILERNEIHHCNNLRTSNSSKSTLGGVNMKVLPAPKLKMTNNHIYSNKGYGVSILQPMEQFFIVAEEALNKRASSGDKKDDKMLFKVMQNLNLEMNNNKIEANVKGDIRIVTS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MASGSKASVPADSFR CCCCCCCCCCHHHCC	8.57	18220336
16	Phosphorylation	VPADSFRTISPDRRG CCHHHCCCCCCCCCC	5.82	22210691
18	Phosphorylation	ADSFRTISPDRRGEK HHHCCCCCCCCCCCC	6.68	22210691
53	Phosphorylation	PVRSVVASPRPVKGK EEEEEEECCCCCCCC	25.83	-
58	Acetylation	VASPRPVKGKAGRET EECCCCCCCCCCHHH	63.40	24846323
60	Acetylation	SPRPVKGKAGRETAR CCCCCCCCCCHHHHH	7.25	24846333
80	Phosphorylation	LPAAQAEDTGEAAAA CCHHHCCCHHHHHHH	32.16	18220336
88	Phosphorylation	TGEAAAAAAEEPLLP HHHHHHHHHCCCCCC	24.64	-
90	Phosphorylation	EAAAAAAEEPLLPVP HHHHHHHCCCCCCCC	21.82	-
145	Acetylation	DADEVMGKYLSEKLK CHHHHHHHHHHHHHC	1.87	7675597
146	Phosphorylation	ADEVMGKYLSEKLKL HHHHHHHHHHHHHCC	27.95	-
218	Phosphorylation	NIANIPRDLVDEILE CCCCCCHHHHHHHHH	15.10	-
340	Phosphorylation	AVECWKKYYEIVMLC HHHHHHHHHHHHHHH	58.70	-
412	Phosphorylation	QQHGDLDLALDNCYS HHCCCHHHHCCCCCC	11.56	-
463	Phosphorylation	TSEPSRDSFVVSKAD ECCCCCCCEEEECCC	18.99	24719451
570	Acetylation	TLGGVNMKVLPAPKL CCCCCCCEEECCCCC	3.28	-
622	Acetylation	SGDKKDDKMLFKVMQ CCCCCCHHHHHHHHH	22.97	7627717
645	Acetylation	NKIEANVKGDIRIVT CEEEEEEECCEEEEC	49.88	-
653	Phosphorylation	GDIRIVTS------- CCEEEECC-------	34.29	-
725	Phosphorylation	------------------------------------------------------------------------------- -------------------------------------------------------------------------------	27.59	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SHP1L_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SHP1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SHP1L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SHP1L_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SHP1L_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, AND MASSSPECTROMETRY.	18220336 [Abstract]