SHLB1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHLB1_RAT
• UniProt AC: Q6AYE2
• Protein Name: Endophilin-B1
• Gene Name: Sh3glb1 {ECO:0000312|EMBL:AAH79085.1}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 365
• Subcellular Localization: Cytoplasm . Golgi apparatus membrane ; Peripheral membrane protein . Mitochondrion outer membrane ; Peripheral membrane protein . Cytoplasmic vesicle, autophagosome membrane . Midbody . Association with the Golgi apparatus depends on the cell type. F
• Protein Description: May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity)..
• Protein Sequence: MNIMDFNVKKLAADAGTFLSRAVQFTEEKLGQAEKTELDAHLENLLSKAECTKVWTEKIMKQTEVLLQPNPNARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETKSSSEQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYVSNNNQTSGTPVPYTLSNTIGPSAVASTGSLVITCPPNLSDLKDSSSTRKARVLYDYDAANSTELSLLADEVITVFSVVGMDSDWLMGERGNQKGKVPITYLELLN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNIMDFNV -------CCCCCCCH	7.47	-
80	Phosphorylation	ARIEEFVYEKLDRKA CCHHHHHHHHCCCCC	16.80	21940666
145	Phosphorylation	TSALNFLTPLRNFIE HHHHHHHHHHHHHHH	19.01	-
157	Phosphorylation	FIEGDYKTIAKERKL HHHCCHHHHHHHHHH	21.67	23984901
200	Phosphorylation	QELRITQSEFDRQAE HHHHHCHHHHHHHHH	31.42	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
145	T	Phosphorylation	Kinase	CDK5	Q03114	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
145	T	Phosphorylation	Phosphorylated at Thr-145 by CDK5; this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHLB1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SHLB1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.