SHKB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHKB1_MOUSE
• UniProt AC: Q6P7W2
• Protein Name: SH3KBP1-binding protein 1
• Gene Name: Shkbp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 704
• Subcellular Localization: Lysosome .
• Protein Description: Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. [PubMed: 21830225]
• Protein Sequence: MAVATTAVEGVPSRGAPGEVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTLKDETGAIFIDRDPTVFAPILNFLRTKELDPRGVHGSSLLHEAQFYGLTPLVRRLQVREELDRSSCGNVLFNGYLPPPVFPVKRRNRHSLVGPQQIGGRPAPVRRSNTMPPNLGNAGLLGRMLDERAPPSPSGQPEEPGMVRLVCGHHNWIAVAYTHFLVCYRLKEASGWQLAFSSPRLDWPIERLALAARVLGGAPGEHDKMVAAATGSEILLWALQAQGGGSEIGVFHLGVPVEALFFVGNQLIATSHTGRIGVWNAVTKHWQVQEVQPITSYDAAGSFLLLGCSNGSIYYVDVQKFPLRMKDNDLLVSELYRDPAEDGVTALSVYLTPKTSDSGNWIEIAYGTSSGVVRVIVQHPETVGSGPQLFQTFSVHRSPVTKIMLSEKHLISVCADNNHVRTWSVTRFRGMISTQPGSTPLASFKILALESVDGLGGCSAGNDIGPYGERDDQQVFIQKVVPNASQLFVRLSSTGQRVCSVRSVDGSPTTAFTVLECEGSRRLGSRPRRYLLTGQANGSLAMWDLTTAMDGLGQTPAGGLTEEELMDQLEQCELSPLASSRGSFPSPSPRTSLTSLHSASSNTSLYGPRGSPSPPQAEARRRGAGSFVDRCQELARGAPELRWPPTPAPRPSTSLGNPLTALKKTLNETSF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVATTAVE ------CCCEEECCC	10.31	-
36	Phosphorylation	RFSTSRQTLTWIPDS EEECCCCEEEECCHH	25.66	22705319
144	Phosphorylation	VKRRNRHSLVGPQQI CCCCCCCCCCCCHHC	22.85	25266776
161	Phosphorylation	RPAPVRRSNTMPPNL CCCCCCCCCCCCCCC	26.53	26643407
163	Phosphorylation	APVRRSNTMPPNLGN CCCCCCCCCCCCCCC	32.09	25266776
185	Phosphorylation	LDERAPPSPSGQPEE HCCCCCCCCCCCCCC	30.55	22942356
187	Phosphorylation	ERAPPSPSGQPEEPG CCCCCCCCCCCCCCC	55.16	28066266
431	Phosphorylation	QTFSVHRSPVTKIML EEEEEECCCCCEEEE	14.62	-
434	Phosphorylation	SVHRSPVTKIMLSEK EEECCCCCEEEECCC	20.45	-
435	Ubiquitination	VHRSPVTKIMLSEKH EECCCCCEEEECCCE	26.76	-
439	Phosphorylation	PVTKIMLSEKHLISV CCCEEEECCCEEEEE	27.50	-
616	Phosphorylation	PLASSRGSFPSPSPR HHHCCCCCCCCCCCC	32.64	22817900
619	Phosphorylation	SSRGSFPSPSPRTSL CCCCCCCCCCCCCCC	35.68	29472430
621	Phosphorylation	RGSFPSPSPRTSLTS CCCCCCCCCCCCCCE	31.20	22817900
631	Phosphorylation	TSLTSLHSASSNTSL CCCCEEEECCCCCCC	34.83	29472430
633	Phosphorylation	LTSLHSASSNTSLYG CCEEEECCCCCCCCC	27.43	29472430
634	Phosphorylation	TSLHSASSNTSLYGP CEEEECCCCCCCCCC	43.79	29472430
636	Phosphorylation	LHSASSNTSLYGPRG EEECCCCCCCCCCCC	23.27	29472430
637	Phosphorylation	HSASSNTSLYGPRGS EECCCCCCCCCCCCC	24.68	29472430
644	Phosphorylation	SLYGPRGSPSPPQAE CCCCCCCCCCCCHHH	24.39	25521595
646	Phosphorylation	YGPRGSPSPPQAEAR CCCCCCCCCCHHHHH	51.41	25521595
659	Phosphorylation	ARRRGAGSFVDRCQE HHHHCCCHHHHHHHH	22.89	26824392
693	Phosphorylation	TSLGNPLTALKKTLN CCCCCHHHHHHHHHH	31.07	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SHKB1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHKB1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHKB1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SHKB1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.