SHE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHE_HUMAN
• UniProt AC: Q5VZ18
• Protein Name: SH2 domain-containing adapter protein E
• Gene Name: SHE
• Organism: Homo sapiens (Human).
• Sequence Length: 495
• Protein Sequence: MQWSPTPGASACLGWASSLACSTAPTLLGRAGRGPLMAAKWFKEFPLNLKTVSERAKPGGGGGKLRKNSEAGGAGPGPGKGRKNSAAELGSGRAGVGPKDSRLSRDSLQGLIQAAAGKGRKNSRATEEEPHRGATKSSGCSTYINRLIKVDTQEKNGKSNYPSSSSSSSSSSSSASSSPSSLGPELDKGKIIKQQETVIILEDYADPYDAKRTKGQRDAERVGENDGYMEPYDAQQMITEIRRRGSKDPLVKALQLLDSPCEPADGGLKSETLAKRRSSKDLLGKPPQLYDTPYEPAEGGPRAEGKARPPDSRLPENDERPAAEYEQPWEWKKEQIVRALSVQFEGAERPSFREETVRQHHRQKSWTQKILKPALSDHSEGEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEKLPFKGAEHMTLLYPVHSKLH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Acetylation	KEFPLNLKTVSERAK HHCCCCCEEHHHHCC	45.89	90545
51	Phosphorylation	EFPLNLKTVSERAKP HCCCCCEEHHHHCCC	32.22	-
64	Ubiquitination	KPGGGGGKLRKNSEA CCCCCCCCCCCCCCC	48.68	-
69	Phosphorylation	GGKLRKNSEAGGAGP CCCCCCCCCCCCCCC	31.68	23403867
85	Phosphorylation	PGKGRKNSAAELGSG CCCCCCCCCHHHCCC	31.71	23403867
91	Phosphorylation	NSAAELGSGRAGVGP CCCHHHCCCCCCCCC	37.42	30576142
101	Phosphorylation	AGVGPKDSRLSRDSL CCCCCCCCCCCHHHH	41.05	30576142
104	Phosphorylation	GPKDSRLSRDSLQGL CCCCCCCCHHHHHHH	32.69	23403867
107	Phosphorylation	DSRLSRDSLQGLIQA CCCCCHHHHHHHHHH	22.83	27251275
118	Acetylation	LIQAAAGKGRKNSRA HHHHHHCCCCCCCCC	51.30	20167786
123	Phosphorylation	AGKGRKNSRATEEEP HCCCCCCCCCCCCCC	26.74	-
126	Phosphorylation	GRKNSRATEEEPHRG CCCCCCCCCCCCCCC	42.70	-
155	Ubiquitination	IKVDTQEKNGKSNYP EEECCCCCCCCCCCC	62.27	30230243
161	Phosphorylation	EKNGKSNYPSSSSSS CCCCCCCCCCCCCCC	16.16	25954137
164	Phosphorylation	GKSNYPSSSSSSSSS CCCCCCCCCCCCCCC	29.72	-
165	Phosphorylation	KSNYPSSSSSSSSSS CCCCCCCCCCCCCCC	38.28	-
166	Phosphorylation	SNYPSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
167	Phosphorylation	NYPSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
168	Phosphorylation	YPSSSSSSSSSSSSA CCCCCCCCCCCCCCC	35.87	-
170	Phosphorylation	SSSSSSSSSSSSASS CCCCCCCCCCCCCCC	35.87	25954137
171	Phosphorylation	SSSSSSSSSSSASSS CCCCCCCCCCCCCCC	35.87	25954137
172	Phosphorylation	SSSSSSSSSSASSSP CCCCCCCCCCCCCCC	30.20	-
180	Phosphorylation	SSASSSPSSLGPELD CCCCCCCHHHCCCCC	39.89	-
181	Phosphorylation	SASSSPSSLGPELDK CCCCCCHHHCCCCCC	40.50	-
204	Phosphorylation	TVIILEDYADPYDAK EEEEECCCCCHHHHC	11.97	-
228	Phosphorylation	RVGENDGYMEPYDAQ HHCCCCCCCCCCCHH	10.94	-
246	Phosphorylation	TEIRRRGSKDPLVKA HHHHHCCCCCHHHHH	31.88	23403867
278	Phosphorylation	ETLAKRRSSKDLLGK HHHHHHHCCHHHCCC	45.86	23312004
279	Phosphorylation	TLAKRRSSKDLLGKP HHHHHHCCHHHCCCC	28.51	23312004
290	Phosphorylation	LGKPPQLYDTPYEPA CCCCCCCCCCCCCCC	16.72	23312004
312	Phosphorylation	GKARPPDSRLPENDE CCCCCCCCCCCCCCC	41.30	-
341	Phosphorylation	EQIVRALSVQFEGAE HHHHHHHHHEECCCC	16.94	23403867
376	Phosphorylation	KILKPALSDHSEGEK HHHHHHHCCCCCCCC	35.07	23403867
379	Phosphorylation	KPALSDHSEGEKVDP HHHHCCCCCCCCCCC	52.89	23403867
452	Phosphorylation	AQTKDNKYTLNQTSA EECCCCCEECCCHHH	23.78	-
470	Phosphorylation	SIPEVVHYYSNEKLP CCHHHHHHHCCCCCC	9.29	-
471	Phosphorylation	IPEVVHYYSNEKLPF CHHHHHHHCCCCCCC	7.08	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SHE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DOK3_HUMAN	DOK3	physical	25814554
MOD5_HUMAN	TRIT1	physical	25814554

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.