dbPTM

SH2B2_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SH2B2_RAT
UniProt AC	Q9Z200
Protein Name	SH2B adapter protein 2
Gene Name	Sh2b2
Organism	Rattus norvegicus (Rat).
Sequence Length	621
Subcellular Localization	Cytoplasm. Membrane. Recruited to the membrane by binding to an autophosphorylated receptor after receptor stimulation by its extracellular ligand.
Protein Description	Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis (By similarity). Involved in stimulation of glucose uptake by insulin. Involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Induces cytoskeletal reorganization and neurite outgrowth in cultured neurons..
Protein Sequence	MNGATPGSAAAPAPVPDWRQFCELHAQVAAVDFAHKFCRFLRDNPTYDTPDAGTSFSRHFAANFLAVFSEEVRRVLGTAADTMEPEPAVTSVTSALKTATYGHSRSSEDVSAHVATKARVRKGFSLRNMSLCVVDGVRDLWHRRASPEPEGGATPKTTEPVSEPRDKWTRRLRLARTLAAKVELVDIQREGALRFMVADDAASGPGGTAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASRVTSCSCELLTEADMPRPPETMTAVGAVVTAPHGRARDTVGESLAHVPLETFLQTLESSGGVSESNNTGDEGAELDPDAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPDPGPAPNTAAPVPACWTEPAGQHYFSSLATATCPPTSPSNGAGASSSSGSSSSATSVPPRPAEGPLSARSRSNSTEHLLEAASGATEEPADATLGRARAVENQYSFY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Phosphorylation	FLRDNPTYDTPDAGT HHCCCCCCCCCCCCC	21.05	-
98	Phosphorylation	SVTSALKTATYGHSR HHHHHHHHHHCCCCC	25.69	23984901
100	Phosphorylation	TSALKTATYGHSRSS HHHHHHHHCCCCCCC	34.96	23984901
101	Phosphorylation	SALKTATYGHSRSSE HHHHHHHCCCCCCCH	15.46	23984901
104	Phosphorylation	KTATYGHSRSSEDVS HHHHCCCCCCCHHHH	29.51	23984901
106	Phosphorylation	ATYGHSRSSEDVSAH HHCCCCCCCHHHHHH	40.88	27097102
107	Phosphorylation	TYGHSRSSEDVSAHV HCCCCCCCHHHHHHH	36.38	27097102
111	Phosphorylation	SRSSEDVSAHVATKA CCCCHHHHHHHHHHH	25.61	22673903
125	Phosphorylation	ARVRKGFSLRNMSLC HHHCCCCCCCCEEEE	34.78	25532521
130	Phosphorylation	GFSLRNMSLCVVDGV CCCCCCEEEEEEECH	23.36	-
146	Phosphorylation	DLWHRRASPEPEGGA HHHHHCCCCCCCCCC	28.16	28432305
154	Phosphorylation	PEPEGGATPKTTEPV CCCCCCCCCCCCCCC	28.70	28432305
162	Phosphorylation	PKTTEPVSEPRDKWT CCCCCCCCCCCCHHH	53.23	22673903
303	Phosphorylation	GCVDPGDSEEDTGLS CCCCCCCCHHHHCCC	49.12	-
584	Phosphorylation	EGPLSARSRSNSTEH CCCCCCCCCCCCHHH	39.51	23984901
586	Phosphorylation	PLSARSRSNSTEHLL CCCCCCCCCCHHHHH	36.06	28432305
588	Phosphorylation	SARSRSNSTEHLLEA CCCCCCCCHHHHHHH	36.10	30240740
589	Phosphorylation	ARSRSNSTEHLLEAA CCCCCCCHHHHHHHH	31.51	25532521
597	Phosphorylation	EHLLEAASGATEEPA HHHHHHHCCCCCCCC	35.69	23984901
600	Phosphorylation	LEAASGATEEPADAT HHHHCCCCCCCCHHH	44.39	25575281
618	Phosphorylation	ARAVENQYSFY---- HHHHHHCCCCC----	16.60	14690593

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
588	S	Phosphorylation	Kinase	AKT1	P31749	PSP
588	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
618	Y	Phosphorylation	Kinase	INSR	P15127	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SH2B2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SH2B2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SH2B2_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SH2B2_RAT

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"APS facilitates c-Cbl tyrosine phosphorylation and GLUT4translocation in response to insulin in 3T3-L1 adipocytes."; Liu J., Kimura A., Baumann C.A., Saltiel A.R.; Mol. Cell. Biol. 22:3599-3609(2002). Cited for: FUNCTION, INTERACTION WITH CBL AND CAP, AND PHOSPHORYLATION ATTYR-618.	11997497 [Abstract]