dbPTM

SFSWA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SFSWA_MOUSE
UniProt AC	Q3USH5
Protein Name	Splicing factor, suppressor of white-apricot homolog
Gene Name	Sfswap
Organism	Mus musculus (Mouse).
Sequence Length	945
Subcellular Localization	Nucleus .
Protein Description	Plays a role as an alternative splicing regulator. Regulates its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10 (By similarity)..
Protein Sequence	MYGAGGGRAKPERKGGVKEEAGPGGTGTGGNRVELLVFGYACKLFRDDERALAQEQGQHLIPWMGDPKILIDRYDGRGHLHDLSAYDAEYATWNRDYQLSEEEARVEALCDEERYLALHTDLLEEEARQEEEYKRLSEALAEDGNYSAVGFTYGSDYYDPSEPTEEEEPSKQREKNEAENLEENEEPFIAPLGLSVPSDVELPPTAKMHAIIERTANFVCKQGAQFEIMLKAKQARNSQFDFLRFDHYLNPYYKFIQKAMKEGRYTVLAESKNEEKKKSGPTSDNEEEDDEEDGSYLHPSLFASKKSSRLEELMKPLKVVDPDHPLAALVRKAQADSSAPAPPTADGTPAQPSQVEYTADSTVAAMYYSYYMLPDGTYCLAPPPPGIDVATYYSTLPAGVTVSSSPGVTTTVPPPPGTTPPPPPTTAEPSSGVTSTTTTTSALAPVAIIPPPPDIQPVIDKLAEYVARNGLKFETSVRAKNDQRFEFLQPWHQYNAYYEFKKQFFLQKEGGGSTQAASTAEEAPTETAVEESGEAGEDGAPEGMAETGGRGSGKKEAGSSKSTVDGKLVKASFAPISFAIKAKENDLLPLEKNRVKLDDDSEEDEESRECQESTSSVANPSPAAAPPSVAVEEKKPQLTQEELEAKQAKQKLEDRLAAAAREKLAQASKESKEKQLQAERKRKAALFLQTLKNPLPEAEVGKLEESTFGVEDTGVMPCPLLVGGRTLPILEGKPPERPSNRCRDPPREEEREKKKKKHKKRSRTRSRSPKYHSSSKPRSRSHSKAKHSLPSAYRTVRRSRSRSRSPRRRAHSPERRREERSVPTAYRMSGSPGVSRKRTRSRSPHEKKKKRRSRSRTKAKARSQSTSPSKQAAQRPSAHSAHSASISPVESRGSSQERSRGVSQEKDGQISSAIVSSVQSKITQDLMAKVRAMLAASKNLQTSAS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74	Phosphorylation	PKILIDRYDGRGHLH CEEEEECCCCCCCCC	20.99	28542873
279	Phosphorylation	KNEEKKKSGPTSDNE CCHHHCCCCCCCCCC	59.91	24925903
282	Phosphorylation	EKKKSGPTSDNEEED HHCCCCCCCCCCCCC	52.84	24925903
283	Phosphorylation	KKKSGPTSDNEEEDD HCCCCCCCCCCCCCC	41.39	24925903
295	Phosphorylation	EDDEEDGSYLHPSLF CCCCCCCCCCCHHHH	36.52	25159016
296	Phosphorylation	DDEEDGSYLHPSLFA CCCCCCCCCCHHHHC	17.98	25159016
300	Phosphorylation	DGSYLHPSLFASKKS CCCCCCHHHHCCCCC	25.93	25777480
304	Phosphorylation	LHPSLFASKKSSRLE CCHHHHCCCCCHHHH	33.03	25777480
315	Acetylation	SRLEELMKPLKVVDP HHHHHHHCCCCCCCC	60.88	23806337
583	Acetylation	ISFAIKAKENDLLPL EEEEEEECCCCCCCC	52.64	22826441
601	Phosphorylation	RVKLDDDSEEDEESR CCCCCCCCHHHHHHH	50.29	25521595
607	Phosphorylation	DSEEDEESRECQEST CCHHHHHHHHHHHHH	31.19	26239621
613	Phosphorylation	ESRECQESTSSVANP HHHHHHHHHCCCCCC	14.01	26239621
614	Phosphorylation	SRECQESTSSVANPS HHHHHHHHCCCCCCC	25.03	26239621
615	Phosphorylation	RECQESTSSVANPSP HHHHHHHCCCCCCCC	31.90	26239621
616	Phosphorylation	ECQESTSSVANPSPA HHHHHHCCCCCCCCC	25.90	30635358
621	Phosphorylation	TSSVANPSPAAAPPS HCCCCCCCCCCCCCC	27.29	25619855
628	Phosphorylation	SPAAAPPSVAVEEKK CCCCCCCCCCCCCCC	22.96	25777480
639	Phosphorylation	EEKKPQLTQEELEAK CCCCCCCCHHHHHHH	28.78	17525332
775	Phosphorylation	SPKYHSSSKPRSRSH CCCCCCCCCCCCCCC	50.09	24704852
803	Phosphorylation	VRRSRSRSRSPRRRA HHHHHHCCCCCCHHC	38.05	19854140
805	Phosphorylation	RSRSRSRSPRRRAHS HHHHCCCCCCHHCCC	24.81	19854140
812	Phosphorylation	SPRRRAHSPERRREE CCCHHCCCHHHHHHH	27.72	25266776
821	Phosphorylation	ERRREERSVPTAYRM HHHHHHCCCCCHHHH	35.41	28066266
824	Phosphorylation	REERSVPTAYRMSGS HHHCCCCCHHHHCCC	33.88	27600695
826	Phosphorylation	ERSVPTAYRMSGSPG HCCCCCHHHHCCCCC	14.88	26643407
829	Phosphorylation	VPTAYRMSGSPGVSR CCCHHHHCCCCCCCC	27.41	23684622
831	Phosphorylation	TAYRMSGSPGVSRKR CHHHHCCCCCCCCCC	15.92	25521595
835	Phosphorylation	MSGSPGVSRKRTRSR HCCCCCCCCCCCCCC	37.69	25159016
842	Methylation	SRKRTRSRSPHEKKK CCCCCCCCCHHHHHH	51.41	16188819
877	Phosphorylation	KQAAQRPSAHSAHSA HHHHHCCCCHHCCCC	40.58	28066266
880	Phosphorylation	AQRPSAHSAHSASIS HHCCCCHHCCCCCCC	27.65	28066266
883	Phosphorylation	PSAHSAHSASISPVE CCCHHCCCCCCCCCC	24.35	28066266
885	Phosphorylation	AHSAHSASISPVESR CHHCCCCCCCCCCCC	26.98	28066266
887	Phosphorylation	SAHSASISPVESRGS HCCCCCCCCCCCCCC	22.01	28066266
891	Phosphorylation	ASISPVESRGSSQER CCCCCCCCCCCHHHH	42.02	28066266
894	Phosphorylation	SPVESRGSSQERSRG CCCCCCCCHHHHHCC	27.95	-
895	Phosphorylation	PVESRGSSQERSRGV CCCCCCCHHHHHCCC	38.59	-
899	Phosphorylation	RGSSQERSRGVSQEK CCCHHHHHCCCCCCC	32.41	25619855
903	Phosphorylation	QERSRGVSQEKDGQI HHHHCCCCCCCCCCH	35.13	27087446
911	Phosphorylation	QEKDGQISSAIVSSV CCCCCCHHHHHHHHH	13.06	25619855
912	Phosphorylation	EKDGQISSAIVSSVQ CCCCCHHHHHHHHHH	24.52	25619855
916	Phosphorylation	QISSAIVSSVQSKIT CHHHHHHHHHHHHHH	20.76	25619855
917	Phosphorylation	ISSAIVSSVQSKITQ HHHHHHHHHHHHHHH	17.18	25619855
920	Phosphorylation	AIVSSVQSKITQDLM HHHHHHHHHHHHHHH	24.70	25619855
929	Acetylation	ITQDLMAKVRAMLAA HHHHHHHHHHHHHHH	20.49	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SFSWA_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SFSWA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SFSWA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SFSWA_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SFSWA_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-601, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283, AND MASSSPECTROMETRY.	17242355 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-639, AND MASSSPECTROMETRY.	17525332 [Abstract]