SFR19_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SFR19_MOUSE
• UniProt AC: Q5U4C3
• Protein Name: Splicing factor, arginine/serine-rich 19
• Gene Name: Scaf1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1256
• Subcellular Localization: Nucleus.
• Protein Description: May function in pre-mRNA splicing..
• Protein Sequence: MEEEDESRGKTEESGEDRGDGPPDRDPALSPSAFILRAIQQAVGSSLQGDLPNDKDGARCRGLRWRRCCRSPRSEPRSQESGAADTATVLDTAADSFLVELVSILDPPDTWVPSRLDLQPGESEDMLELVAEVRIGDRDPMPLPVPSLFPRLRAWRTGKTVSPQSHASRPACSRHLTLGTGDGGPAPPPAPSSASSSPSPSPSSSSPSPPPPPPPPPPPALPAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDDSPRREPPPPQTLGAPGTPPQADSTRAEGAPRRRVFVLGPEAEACHEGKVSVEVVTAGAPALSLPPLPPTDPEIEEGEIVQPEEEPRVAVSLFRAARPRQPPASVATLASVAAPAAPPASAPRAPEGDDFLSLHADSDGEGALQVDLGEPPAPPAADARWGGLDLRRKILTQRRERYRQRSASPGPPPARKKARRERQRSGDPAPPDSPSWEAKKHRSRERKLGSHSTARRRSRSRSRRRSRSRSADRRRGGHRSRSREKRRRRRRSASPPPAASSSSSSRRERHRGKRREGGKKKKKRSRSRAEKRSGDLEKLPASVPPSGSDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRPDKAEPRAPSPAPAVSPKREVLYDSEGLSADERGGKSDKDRRRSGAASSSSSSREKGSRRKALDGDRGRDRDRSSKKTRPPKDSTPGSGPLPKAPPSSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDSSSSGLGSIGVKFSRDRESRSPFLKPDERAPAEVAKVAPGSNKPKKTKAKAKAGAKKAKGTKGKTKPSKTRKKVRSGGSSTASGGPGSLKKSKADSCSQAASAKGTEETSWSGEERTTKAPSTPPPKVAPPPPALTPDSQTVDSSCKTPEVSFLPEEASEDTGVRVGAEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPAARISQLPTLPPPMPWNLPAGVDCTTSGVLALTALLFKMEEANLASRAKAQELIQATNQILSHRKPSSTLGVTPAPVPTSLGLPPGPSSYLLPGSLPIGGCGSTPPTPTGLAPASDKREGSSSSEGRGDTDKYLKKLHTQERAVEEVKLAIKPYYQKKDITKEEYKDILRKAVHKICHSKSGEINPVKVSNLVRAYVQRYRYFRKHGRKPGDPPGPPRPPKEPGPPDKGGPGLPLPPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Ubiquitination	QGDLPNDKDGARCRG CCCCCCCCCCCCCCC	65.78	22790023
160	Phosphorylation	RAWRTGKTVSPQSHA HHHHCCCCCCCCCCC	27.79	29472430
162	Phosphorylation	WRTGKTVSPQSHASR HHCCCCCCCCCCCCC	23.58	29472430
229	Phosphorylation	PAPRFDIYDPFHPTD CCCCCCCCCCCCCCC	21.29	25619855
235	Phosphorylation	IYDPFHPTDEAYSPP CCCCCCCCCCCCCCC	37.59	24925903
239	Phosphorylation	FHPTDEAYSPPPAPE CCCCCCCCCCCCCCC	21.47	24925903
240	Phosphorylation	HPTDEAYSPPPAPEQ CCCCCCCCCCCCCCC	37.67	24925903
249	Phosphorylation	PPAPEQKYDPFEPTG CCCCCCCCCCCCCCC	28.66	25293948
255	Phosphorylation	KYDPFEPTGSNPSSS CCCCCCCCCCCCCCC	46.15	25293948
257	Phosphorylation	DPFEPTGSNPSSSAG CCCCCCCCCCCCCCC	48.31	25293948
260	Phosphorylation	EPTGSNPSSSAGTPS CCCCCCCCCCCCCCC	40.97	25293948
261	Phosphorylation	PTGSNPSSSAGTPSP CCCCCCCCCCCCCCH	26.01	25293948
262	Phosphorylation	TGSNPSSSAGTPSPE CCCCCCCCCCCCCHH	34.75	25293948
265	Phosphorylation	NPSSSAGTPSPEEEE CCCCCCCCCCHHHHH	21.95	25293948
267	Phosphorylation	SSSAGTPSPEEEEEE CCCCCCCCHHHHHHH	44.79	25293948
291	Phosphorylation	SQSISRISETLAGIY HHHHHHHHHHHHHHC	24.34	25159016
298	Phosphorylation	SETLAGIYDDNSLSQ HHHHHHHCCCCCCCC	19.14	25159016
302	Phosphorylation	AGIYDDNSLSQDFPG HHHCCCCCCCCCCCC	36.07	25159016
304	Phosphorylation	IYDDNSLSQDFPGDD HCCCCCCCCCCCCCC	27.76	25159016
312	Phosphorylation	QDFPGDDSPRREPPP CCCCCCCCCCCCCCC	25.66	25619855
322	Phosphorylation	REPPPPQTLGAPGTP CCCCCCCCCCCCCCC	32.69	25619855
328	Phosphorylation	QTLGAPGTPPQADST CCCCCCCCCCCCCCC	30.64	25521595
334	Phosphorylation	GTPPQADSTRAEGAP CCCCCCCCCCCCCCC	23.86	25619855
335	Phosphorylation	TPPQADSTRAEGAPR CCCCCCCCCCCCCCC	34.15	25619855
442	Phosphorylation	PEGDDFLSLHADSDG CCCCCCEEEECCCCC	20.36	27087446
447	Phosphorylation	FLSLHADSDGEGALQ CEEEECCCCCCCCEE	48.58	27087446
487	Phosphorylation	LTQRRERYRQRSASP HHHHHHHHHHHHCCC	13.32	29514104
491	Phosphorylation	RERYRQRSASPGPPP HHHHHHHHCCCCCCH	25.43	25521595
493	Phosphorylation	RYRQRSASPGPPPAR HHHHHHCCCCCCHHH	31.47	25521595
510	Phosphorylation	ARRERQRSGDPAPPD HHHHHHHHCCCCCCC	38.93	25521595
518	Phosphorylation	GDPAPPDSPSWEAKK CCCCCCCCCCHHHHH	26.97	25521595
520	Phosphorylation	PAPPDSPSWEAKKHR CCCCCCCCHHHHHHH	41.31	23684622
532	Acetylation	KHRSRERKLGSHSTA HHHHHHHHHCCHHHH	53.07	30988429
535	Phosphorylation	SRERKLGSHSTARRR HHHHHHCCHHHHHHH	25.38	26824392
537	Phosphorylation	ERKLGSHSTARRRSR HHHHCCHHHHHHHHH	26.01	28066266
538	Phosphorylation	RKLGSHSTARRRSRS HHHCCHHHHHHHHHH	20.82	28066266
577	Phosphorylation	KRRRRRRSASPPPAA HHHHHHHCCCCCCCC	31.15	25521595
579	Phosphorylation	RRRRRSASPPPAASS HHHHHCCCCCCCCCC	38.90	25521595
585	Phosphorylation	ASPPPAASSSSSSRR CCCCCCCCCCCHHHH	32.62	25159016
586	Phosphorylation	SPPPAASSSSSSRRE CCCCCCCCCCHHHHH	29.52	23984901
587	Phosphorylation	PPPAASSSSSSRRER CCCCCCCCCHHHHHH	31.57	23984901
588	Phosphorylation	PPAASSSSSSRRERH CCCCCCCCHHHHHHH	33.99	23984901
589	Phosphorylation	PAASSSSSSRRERHR CCCCCCCHHHHHHHH	29.79	23984901
590	Phosphorylation	AASSSSSSRRERHRG CCCCCCHHHHHHHHC	36.99	25159016
618	Phosphorylation	RSRAEKRSGDLEKLP HHHHHHHHCCHHHCC	47.96	26824392
627	Phosphorylation	DLEKLPASVPPSGSD CHHHCCCCCCCCCCC	32.96	28285833
631	Phosphorylation	LPASVPPSGSDRDSR CCCCCCCCCCCHHHH	44.87	25338131
633	Phosphorylation	ASVPPSGSDRDSRRR CCCCCCCCCHHHHHC	33.53	27149854
663	Phosphorylation	FAIKRTITVGRPDKA EEEEEEEECCCCCCC	19.12	-
669	Acetylation	ITVGRPDKAEPRAPS EECCCCCCCCCCCCC	58.28	15606775
676	Phosphorylation	KAEPRAPSPAPAVSP CCCCCCCCCCCCCCC	32.48	27087446
682	Phosphorylation	PSPAPAVSPKREVLY CCCCCCCCCCCEEEE	27.15	27087446
689	Phosphorylation	SPKREVLYDSEGLSA CCCCEEEECCCCCCC	23.69	22324799
691	Phosphorylation	KREVLYDSEGLSADE CCEEEECCCCCCCCC	21.73	25521595
695	Phosphorylation	LYDSEGLSADERGGK EECCCCCCCCCCCCC	44.52	25521595
699	Dimethylation	EGLSADERGGKSDKD CCCCCCCCCCCCHHH	60.76	-
699	Methylation	EGLSADERGGKSDKD CCCCCCCCCCCCHHH	60.76	18965035
710	Phosphorylation	SDKDRRRSGAASSSS CHHHHHHHCCCCCCC	30.85	-
716	Phosphorylation	RSGAASSSSSSREKG HHCCCCCCCCCCCCC	31.57	-
724	Phosphorylation	SSSREKGSRRKALDG CCCCCCCCCCHHHCC	39.72	-
750	Phosphorylation	KTRPPKDSTPGSGPL CCCCCCCCCCCCCCC	42.50	25521595
751	Phosphorylation	TRPPKDSTPGSGPLP CCCCCCCCCCCCCCC	41.63	25521595
754	Phosphorylation	PKDSTPGSGPLPKAP CCCCCCCCCCCCCCC	38.14	29472430
793	Phosphorylation	VLIREGVSSTTPAKD HHCCCCCCCCCCCCC	32.59	26643407
794	Phosphorylation	LIREGVSSTTPAKDS HCCCCCCCCCCCCCC	33.62	26643407
795	Phosphorylation	IREGVSSTTPAKDSS CCCCCCCCCCCCCCC	29.32	26643407
796	Phosphorylation	REGVSSTTPAKDSSS CCCCCCCCCCCCCCC	24.17	25263469
801	Phosphorylation	STTPAKDSSSSGLGS CCCCCCCCCCCCCCH	31.26	26643407
802	Phosphorylation	TTPAKDSSSSGLGSI CCCCCCCCCCCCCHH	38.36	26643407
808	Phosphorylation	SSSSGLGSIGVKFSR CCCCCCCHHEEEECC	22.63	25619855
819	Phosphorylation	KFSRDRESRSPFLKP EECCCCCCCCCCCCC	38.66	28973931
821	Phosphorylation	SRDRESRSPFLKPDE CCCCCCCCCCCCCCC	29.32	26824392
841	Phosphorylation	VAKVAPGSNKPKKTK HHHHCCCCCCCCHHH	40.39	28066266
876	Phosphorylation	KTRKKVRSGGSSTAS CCCCCHHCCCCCCCC	50.96	29895711
879	Phosphorylation	KKVRSGGSSTASGGP CCHHCCCCCCCCCCC	28.21	29472430
880	Phosphorylation	KVRSGGSSTASGGPG CHHCCCCCCCCCCCC	31.13	30387612
881	Phosphorylation	VRSGGSSTASGGPGS HHCCCCCCCCCCCCC	26.92	30635358
883	Phosphorylation	SGGSSTASGGPGSLK CCCCCCCCCCCCCCC	44.35	30635358
888	Phosphorylation	TASGGPGSLKKSKAD CCCCCCCCCCHHHCC	39.90	29895711
906	Phosphorylation	QAASAKGTEETSWSG HHHHHCCCCCCCCCC	29.91	25159016
909	Phosphorylation	SAKGTEETSWSGEER HHCCCCCCCCCCCCC	29.30	30352176
910	Phosphorylation	AKGTEETSWSGEERT HCCCCCCCCCCCCCC	23.64	23684622
912	Phosphorylation	GTEETSWSGEERTTK CCCCCCCCCCCCCCC	35.77	25521595
917	Phosphorylation	SWSGEERTTKAPSTP CCCCCCCCCCCCCCC	35.61	26643407
918	Phosphorylation	WSGEERTTKAPSTPP CCCCCCCCCCCCCCC	31.28	26643407
922	Phosphorylation	ERTTKAPSTPPPKVA CCCCCCCCCCCCCCC	59.41	25159016
923	Phosphorylation	RTTKAPSTPPPKVAP CCCCCCCCCCCCCCC	38.46	28542873
936	Phosphorylation	APPPPALTPDSQTVD CCCCCCCCCCCCCCC	27.44	25521595
939	Phosphorylation	PPALTPDSQTVDSSC CCCCCCCCCCCCCCC	29.02	25521595
941	Phosphorylation	ALTPDSQTVDSSCKT CCCCCCCCCCCCCCC	30.17	22942356
944	Phosphorylation	PDSQTVDSSCKTPEV CCCCCCCCCCCCCCC	33.04	25619855
945	Phosphorylation	DSQTVDSSCKTPEVS CCCCCCCCCCCCCCC	18.37	25521595
948	Phosphorylation	TVDSSCKTPEVSFLP CCCCCCCCCCCCCCC	29.07	25521595
952	Phosphorylation	SCKTPEVSFLPEEAS CCCCCCCCCCCHHHC	21.28	21659605
959	Phosphorylation	SFLPEEASEDTGVRV CCCCHHHCCCCCCCC	39.01	30635358
962	Phosphorylation	PEEASEDTGVRVGAE CHHHCCCCCCCCCCH	33.26	30635358
1012	Phosphorylation	AGSTAGDSGAEDGPA CCCCCCCCCCCCCCC	38.70	25338131
1097	Phosphorylation	VTPAPVPTSLGLPPG CCCCCCCCCCCCCCC	36.50	25159016
1098	Phosphorylation	TPAPVPTSLGLPPGP CCCCCCCCCCCCCCC	17.86	25159016
1106	Phosphorylation	LGLPPGPSSYLLPGS CCCCCCCHHHCCCCC	37.21	25159016
1107	Phosphorylation	GLPPGPSSYLLPGSL CCCCCCHHHCCCCCC	23.96	25159016
1108	Phosphorylation	LPPGPSSYLLPGSLP CCCCCHHHCCCCCCC	19.32	25159016
1113	Phosphorylation	SSYLLPGSLPIGGCG HHHCCCCCCCCCCCC	29.09	25159016
1121	Phosphorylation	LPIGGCGSTPPTPTG CCCCCCCCCCCCCCC	41.64	25159016
1122	Phosphorylation	PIGGCGSTPPTPTGL CCCCCCCCCCCCCCC	20.69	25159016
1125	Phosphorylation	GCGSTPPTPTGLAPA CCCCCCCCCCCCCCC	34.39	25159016
1127	Phosphorylation	GSTPPTPTGLAPASD CCCCCCCCCCCCCCC	47.51	-
1139	Phosphorylation	ASDKREGSSSSEGRG CCCCCCCCCCCCCCC	23.46	23684622
1140	Phosphorylation	SDKREGSSSSEGRGD CCCCCCCCCCCCCCC	49.06	23684622
1142	Phosphorylation	KREGSSSSEGRGDTD CCCCCCCCCCCCCHH	46.12	29514104
1170	Ubiquitination	EEVKLAIKPYYQKKD HHHHHHHHHHCCCCC	22.74	27667366
1208	Phosphorylation	EINPVKVSNLVRAYV CCCCCHHHHHHHHHH	20.80	28059163
1214	Phosphorylation	VSNLVRAYVQRYRYF HHHHHHHHHHHHHHH	6.12	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SFR19_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SFR19_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SFR19_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SFR19_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-328; SER-691; SER-695AND SER-821, AND MASS SPECTROMETRY.
PubMed: 19367708

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240; SER-510; SER-518;SER-691; SER-695; SER-912 AND THR-936, AND MASS SPECTROMETRY.
PubMed: 17242355