SFC6_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SFC6_SCHPO
• UniProt AC: O60174
• Protein Name: Transcription factor tau subunit sfc6
• Gene Name: sfc6 {ECO:0000312|EMBL:CAA18865.1}
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 582
• Subcellular Localization: Nucleus .
• Protein Description: TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. Cooperates with sfc3 in DNA binding. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization..
• Protein Sequence: MGPKSKEYENPSSYKNDEDNDDDGDFVLENVMSEEDIEIETPSRNRKRVSTTRRTPSKPIRSQPLTPSSSKGAGNEPKSQNSSTTRGSAKKQSSKGLEEKLINSYGTHVESLNKGRRLIEIWKYYETAPGQSSFEGQTSSDSKLQTLLNLDGQQLLSYSENPFYLFEVKNLSISFHFESPQQVEPCQPVNPFKENPQKSGFVVNTGIPLSSVSWLPTNKETQFLAVGGMLKFSETTESVFMRTSGRNQIQLWKLENKTNFKSEFILYHDWGSVLQLEWCPTISVEDSILGFLAVVCSDGKLRVLRVPRSPVKFHVFVEQADFTFGFNDSLISCCTWVSPEHGDIHQILVGCSNGYLALWDILSSQECPLFYIPYHDSYIHNVVQCLDDFPWLFLTTAFDCYTRIFDIRDPIIDNRPLSHKRDICYTITWNNMLQSIISCSESQSVVIESLRGTSTQLLDERNGSIISLSNSKFHPFVACAASDGIVTIVNPFRLLGFSHKQKANVHRIFQLEYSEKQDSYRMLDGFRPRLPKAKKLDMYIYPWQIQVNKVEWNGNKGYAGWLASGMACGILRVEDLSAVERR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Phosphorylation	TPSKPIRSQPLTPSS CCCCCCCCCCCCCCC	36.55	21712547
66	Phosphorylation	PIRSQPLTPSSSKGA CCCCCCCCCCCCCCC	28.01	24763107
68	Phosphorylation	RSQPLTPSSSKGAGN CCCCCCCCCCCCCCC	41.84	21712547
69	Phosphorylation	SQPLTPSSSKGAGNE CCCCCCCCCCCCCCC	36.95	21712547
70	Phosphorylation	QPLTPSSSKGAGNEP CCCCCCCCCCCCCCC	39.17	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SFC6_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SFC6_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SFC6_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SFC4_SCHPO	sfc4	physical	10906331
SFC1_SCHPO	sfc1	physical	10906331
SFC9_SCHPO	sfc9	physical	26257282

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.