dbPTM

SET2_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SET2_CAEEL
UniProt AC	Q18221
Protein Name	Histone-lysine N-methyltransferase set-2
Gene Name	set-2
Organism	Caenorhabditis elegans.
Sequence Length	1507
Subcellular Localization	Nucleus . Localized in mitotic and mid-late-stage meiotic nuclei but is undetectable in early pachytene nuclei.
Protein Description	Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells. [PubMed: 21527717]
Protein Sequence	MSTHDMNHHPPRKSHSKRDKPSSSNSGPKIENHKCKWAWQKVFETGKSFLRRDGFPQDCKSKEDFERIKRTGVRKTSENMLEDPRKNFESLQQSSVYQTNSFRNPRYLCRAHLRVDSYYCTIPPKREVSLFNMDDNCTEVLLRDFAKDCGKVEKAYVCIHPETKRHMKMAYVKFATVKEAHNFYSMYHAQNLLATKCTPRIDPFLSILNEEYEVATNGQVLPILPDDLASIDPSVLRDLRANFLRDQNEKYELAMRNTYEDEGGMLSGVIMDTSDHYERDYTMDHDVGPSSMKMSPIPPPPIKEESPPPPPPPPVASVSNLAPVPSVQLPYYNNIQPSSSTMHMPEFRPTEPPPSYSREDPYRSTSRSSLSRHRNRSRSPSDGMDRSGRSSSRRTHRRPESRNGSKNANGDVVKYETYKMEKRKIKYEGGNKKYEQVHIKERTAVIRGKNQLENVSSESASGSSSVDTYPDFSDEERKKKKRPKSPNRSKKDSRAFGWDSTDESDEDTRRRRSGRSQNRSSERKFQTTSSSSTRRELSSTHTNSVPNLKSHETPPPPPPKGHPSVHLQTPYQHVQPQMIPATYYNLPPQHMAPPPITTSLPPFCDFSQPPPGFTPTFKPITNAPLPTPYQASNIPQPGLVQIAALSAAPEPFSSIPGPPPGPAPIQEDVGRAESPEKPSLSERFSGIFGPTQREEPAQVEVEYDYPLKHSESHDDRHSLEDMDVEVSSDGETVSNVEKIECMEEKKRQDLERIAIARTPIVKKCKKRMMDELSRKVAEDIRQQIMRQCFAALDEKLHLKAIADEEKRKKEREEKARQEAEKPSNHLIADMMTLYNNQSFASSSRGFYRKQKPIPKSHPKHQEHHHHAKASVSTPVHSSSTSRNSSVAPTPQRTVSTSSSSSSAATSARVSEDESDSDSTPGEVQRRKTSVLSNDKRRRRASFSSTSIQSSPERQRDVSSSSRTSSSSSTSSMKQEETADEKSRKRKLIMSSDESSTTGSTATSVVSSRQSSLEPQQEKTDGEPPKKKSQTDFISERVSKIEGEERPLPEPVETSGPIIGDSSYLPYKIVHWEKAGIIEMNLPANSIRAHEYHPFTTEHCYFGIDDPRQPKIQIFDHSPCKSEPGSEPLKITPAPWGPIDNVAETGPLIYMDVVTAPKTVQKKQKPRKQVFEKDPYEYYEPPPTKRPAPPPRFKKTFKPRSEEEKKKIIGDCEDLPDLEDQWYLRAALNEMQSEVKSADELPWKKMLTFKEMLRSEDPLLRLNPIRSKKGLPDAFYEDEELDGVIPVAAGCSRARPYEKMTMKQKRSLVRRPDNESHPTAIFSERDETAIRHQHLASKDMRLLQRRLLTSLGDANNDFFKINQLKFRKKMIKFARSRIHGWGLYAMESIAPDEMIVEYIGQTIRSLVAEEREKAYERRGIGSSYLFRIDLHHVIDATKRGNFARFINHSCQPNCYAKVLTIEGEKRIVIYSRTIIKKGEEITYDYKFPIEDDKIDCLCGAKTCRGYLN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
1028	Phosphorylation	GEPPKKKSQTDFISE CCCCCCCCHHHHHHH	47.38	28854356
1030	Phosphorylation	PPKKKSQTDFISERV CCCCCCHHHHHHHHH	39.71	19530675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SET2_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SET2_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SET2_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SET2_CAEEL !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SET2_CAEEL

Related Literatures of Post-Translational Modification