SERK5_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SERK5_ARATH
• UniProt AC: Q8LPS5
• Protein Name: Somatic embryogenesis receptor kinase 5
• Gene Name: SERK5
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 601
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Serine/threonine-kinase of unknown function..
• Protein Sequence: MEHGSSRGFIWLILFLDFVSRVTGKTQVDALIALRSSLSSGDHTNNILQSWNATHVTPCSWFHVTCNTENSVTRLDLGSANLSGELVPQLAQLPNLQYLELFNNNITGEIPEELGDLMELVSLDLFANNISGPIPSSLGKLGKLRFLRLYNNSLSGEIPRSLTALPLDVLDISNNRLSGDIPVNGSFSQFTSMSFANNKLRPRPASPSPSPSGTSAAIVVGVAAGAALLFALAWWLRRKLQGHFLDVPAEEDPEVYLGQFKRFSLRELLVATEKFSKRNVLGKGRFGILYKGRLADDTLVAVKRLNEERTKGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPEGNPALDWPKRKHIALGSARGLAYLHDHCDQKIIHLDVKAANILLDEEFEAVVGDFGLAKLMNYNDSHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQKAFDLARLANDDDIMLLDWVKEVLKEKKLESLVDAELEGKYVETEVEQLIQMALLCTQSSAMERPKMSEVVRMLEGDGLAERWEEWQKEEMPIHDFNYQAYPHAGTDWLIPYSNSLIENDYPSGPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	N-linked_Glycosylation	NNILQSWNATHVTPC HCHHHHCCCCCCCCC	39.96	-
81	N-linked_Glycosylation	RLDLGSANLSGELVP EEECCCCCCCCCHHH	36.12	-
105	N-linked_Glycosylation	YLELFNNNITGEIPE EHHHHCCCCCCCCCH	34.01	-
129	N-linked_Glycosylation	SLDLFANNISGPIPS HHHHHHCCCCCCCCC	26.77	-
151	N-linked_Glycosylation	LRFLRLYNNSLSGEI HHHHCCCCCCCCCCC	35.88	-
184	N-linked_Glycosylation	LSGDIPVNGSFSQFT CCCCCCCCCCHHHHH	34.73	-
272	Phosphorylation	LRELLVATEKFSKRN HHHHHHHHHHHHCCC	32.03	-
298	Phosphorylation	KGRLADDTLVAVKRL CCCCCCCEEEEEEEC	24.55	-
319	Phosphorylation	GGELQFQTEVEMISM CCEEEEHHHHHHHHH	43.20	24243849
325	Phosphorylation	QTEVEMISMAVHRNL HHHHHHHHHHHHHHH	10.20	24243849
356	Phosphorylation	YPYMANGSVASCLRE EHHCCCCCHHHHHHC	17.83	24243849
359	Phosphorylation	MANGSVASCLRERPE CCCCCHHHHHHCCCC	16.13	-
432	Phosphorylation	KLMNYNDSHVTTAVR HHCCCCCCCCHHHHH	19.07	23111157
435	Phosphorylation	NYNDSHVTTAVRGTI CCCCCCCHHHHHHHH	12.01	23111157
436	Phosphorylation	YNDSHVTTAVRGTIG CCCCCCHHHHHHHHC	23.28	23111157
441	Phosphorylation	VTTAVRGTIGHIAPE CHHHHHHHHCCCCHH	17.14	18694562
449	Phosphorylation	IGHIAPEYLSTGKSS HCCCCHHHHHCCCCC	12.61	25561503
451	Phosphorylation	HIAPEYLSTGKSSEK CCCHHHHHCCCCCCC	33.92	19880383
452	Phosphorylation	IAPEYLSTGKSSEKT CCHHHHHCCCCCCCC	46.14	25561503
456	Phosphorylation	YLSTGKSSEKTDVFG HHHCCCCCCCCCCCH	46.74	24243849
506	Phosphorylation	LKEKKLESLVDAELE HHHHCHHHHHCHHHC	44.09	19880383
532	Phosphorylation	IQMALLCTQSSAMER HHHHHHHCCCCHHCC	31.30	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SERK5_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SERK5_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SERK5_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of SERK5_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Identification of in vitro phosphorylation sites in the Arabidopsisthaliana somatic embryogenesis receptor-like kinases.";
Karlova R., Boeren S., van Dongen W., Kwaaitaal M., Aker J.,Vervoort J., de Vries S.C.;
Proteomics 9:368-379(2009).
Cited for: AUTOPHOSPHORYLATION, AND PHOSPHORYLATION AT THR-441 AND SER-506.
PubMed: 19105183