| UniProt ID | SERC5_HUMAN | |
|---|---|---|
| UniProt AC | Q86VE9 | |
| Protein Name | Serine incorporator 5 {ECO:0000305} | |
| Gene Name | SERINC5 {ECO:0000312|HGNC:HGNC:18825} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 423 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Cytoplasm, perinuclear region . (Microbial infection) Upon HIV-1 infection, it is redirected to perinuclear region following interaction with HIV-1 Nef, excluding it from virions particles, thereby preve |
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| Protein Description | Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. [PubMed: 26416733] | |
| Protein Sequence | MSAQCCAGQLACCCGSAGCSLCCDCCPRIRQSLSTRFMYALYFILVVVLCCIMMSTTVAHKMKEHIPFFEDMCKGIKAGDTCEKLVGYSAVYRVCFGMACFFFIFCLLTLKINNSKSCRAHIHNGFWFFKLLLLGAMCSGAFFIPDQDTFLNAWRYVGAVGGFLFIGIQLLLLVEFAHKWNKNWTAGTASNKLWYASLALVTLIMYSIATGGLVLMAVFYTQKDSCMENKILLGVNGGLCLLISLVAISPWVQNRQPHSGLLQSGVISCYVTYLTFSALSSKPAEVVLDEHGKNVTICVPDFGQDLYRDENLVTILGTSLLIGCILYSCLTSTTRSSSDALQGRYAAPELEIARCCFCFSPGGEDTEEQQPGKEGPRVIYDEKKGTVYIYSYFHFVFFLASLYVMMTVTNWFNHVRSAFHLLP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 35 | Phosphorylation | RIRQSLSTRFMYALY HHHHHHHHHHHHHHH | 32.97 | 23532336 | |
| 39 | Phosphorylation | SLSTRFMYALYFILV HHHHHHHHHHHHHHH | 7.25 | 23532336 | |
| 63 | Ubiquitination | TTVAHKMKEHIPFFE HHHHHHHHHHCCHHH | 51.44 | - | |
| 63 (in isoform 4) | Ubiquitination | - | 51.44 | - | |
| 74 | Ubiquitination | PFFEDMCKGIKAGDT CHHHHHHCCCCCCCH | 57.97 | 29967540 | |
| 77 | Ubiquitination | EDMCKGIKAGDTCEK HHHHCCCCCCCHHHH | 55.79 | 29967540 | |
| 79 | Ubiquitination | MCKGIKAGDTCEKLV HHCCCCCCCHHHHHH | 26.26 | 27667366 | |
| 113 | N-linked_Glycosylation | CLLTLKINNSKSCRA HHHHHHCCCCCHHHH | 45.17 | UniProtKB CARBOHYD | |
| 116 | Ubiquitination | TLKINNSKSCRAHIH HHHCCCCCHHHHEEC | 56.55 | 27667366 | |
| 183 | N-linked_Glycosylation | FAHKWNKNWTAGTAS HHHHCCCCCCCCHHC | 37.81 | UniProtKB CARBOHYD | |
| 345 | Phosphorylation | SDALQGRYAAPELEI CHHHCCCCCCCHHEE | 17.59 | 26657352 | |
| 373 | Ubiquitination | TEEQQPGKEGPRVIY CCCCCCCCCCCEEEE | 67.20 | 29901268 | |
| 373 (in isoform 4) | Ubiquitination | - | 67.20 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SERC5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SERC5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SERC5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SERC5_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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