SERA_RAT - dbPTM
SERA_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SERA_RAT
UniProt AC O08651
Protein Name D-3-phosphoglycerate dehydrogenase
Gene Name Phgdh
Organism Rattus norvegicus (Rat).
Sequence Length 533
Subcellular Localization
Protein Description Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Does not catalyze the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate..
Protein Sequence MAFANLRKILISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGVLVMNTPNGNSLSAAELTCGMLMCLARQIPQATASMKDGKWDRKKFMGTELNGKTLGILGLGRIGREVAARMQAFGMKTVGYDPIISPEVAASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDSTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMHAWAGSPKGTIQVVTQGTSLKNAGTCLSPAVIVGLLREASKQADVNLVNAKLLVKEAGLNVTTSHSPGVPGEQGIGECLLTVALAGAPYQAVGLVQGTTPMLQMLNGAVFRPEVPLRRGQPLLLFRAQPSDPVMLPTMIGLLAEAGVQLLSYQTSKVSDGDTWHVMGLSSLLPSLDAWKQHVSEAFQFCF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAFANLRKI
------CCCCCHHHH		16.56-
12PhosphorylationNLRKILISDSLDPCC
CHHHHHHCCCCCHHH		20.0823984901
14PhosphorylationRKILISDSLDPCCRK
HHHHHCCCCCHHHHH		28.0723984901
21AcetylationSLDPCCRKILQDGGL
CCCHHHHHHHHHCCC		33.58-
58AcetylationLIVRSATKVTADVIN
EEECCCCCCHHHHHH		36.9922902405
58UbiquitinationLIVRSATKVTADVIN
EEECCCCCCHHHHHH		36.99-
78PhosphorylationQVVGRAGTGVDNVDL
HEECCCCCCCCCCCH		32.8021738781
132AcetylationTASMKDGKWDRKKFM
HHHCCCCCCCHHHHC		56.9322902405
137AcetylationDGKWDRKKFMGTELN
CCCCCHHHHCCEEEC		41.2972613607
137UbiquitinationDGKWDRKKFMGTELN
CCCCCHHHHCCEEEC		41.29-
147PhosphorylationGTELNGKTLGILGLG
CEEECCEEEEEECHH		31.4523984901
287PhosphorylationSCPHLGASTKEAQSR
CCCCCCCCHHHHHHH		37.9123984901
288PhosphorylationCPHLGASTKEAQSRC
CCCCCCCHHHHHHHH		32.1623984901
322PhosphorylationVVNAQALTSAFSPHT
EEEHHHHHHCCCCCC		22.4823984901
323PhosphorylationVNAQALTSAFSPHTK
EEHHHHHHCCCCCCC		28.3223984901
326PhosphorylationQALTSAFSPHTKPWI
HHHHHCCCCCCCCCH		18.5823984901
329PhosphorylationTSAFSPHTKPWIGLA
HHCCCCCCCCCHHHH		42.0323984901
358PhosphorylationKGTIQVVTQGTSLKN
CCEEEEEECCCCCCC		23.5623984901
361PhosphorylationIQVVTQGTSLKNAGT
EEEEECCCCCCCCCC		22.5223984901
362PhosphorylationQVVTQGTSLKNAGTC
EEEECCCCCCCCCCC		44.1423984901
369S-nitrosocysteineSLKNAGTCLSPAVIV
CCCCCCCCCCHHHHH		3.28-
369S-nitrosylationSLKNAGTCLSPAVIV
CCCCCCCCCCHHHHH		3.2816418269
371PhosphorylationKNAGTCLSPAVIVGL
CCCCCCCCHHHHHHH		16.9823984901
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SERA_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SERA_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SERA_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SERA_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SERA_RAT

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Related Literatures of Post-Translational Modification

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