SEPT9_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEPT9_RAT
• UniProt AC: Q9QZR6
• Protein Name: Septin-9
• Gene Name: 9-Sep
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 564
• Subcellular Localization: Cytoplasm, cytoskeleton . In embryonic fibroblasts, associated with actin stress fibers. No apparent co-distribution with microtubules, but some colocalization with vimentin filaments in the perinuclear region.
• Protein Description: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)..
• Protein Sequence: MERDRITALKRSFEVEEIEPPNSTPPRRVQTPLLRATVASSSQKFQDLGVKNSEPAARLVDTLSQRSPKPSLRRVDLAGAKAPEPMSRRTELSIDISSKQVESTASTPGPSRFGLKRAEVLGHKTPEPVPRRTEITIVKPQESGLRRVETPASKAPEGSAMPVTDAAPKRVEIQVPKPAEAPNCPLPPQTLENSEAPMSQLQSRLEPRPPVTEVPYRNQEDSEVAPSCVVDMADNPRDAMLKQAPVSRNEKAPVDFGYVGIDSILEQMRRKAMKQGFEFNIMVVGQSGLGKSTLINTLFKSKISRKSVQPISEERIPKTIEIKSITHDIEEKGVRMKLTVIDTPGFGDHINNENCWQPIMKFINDQYEKYLQEEVNINRKKRIPDTRVHCCLYFIPATGHSLRPLDIEFMKRLSKVVNIVPVIAKADTLTLEERVYFKQRITSDLLSNGIDVYPQKEFDEAEDRLVNEKFREMIPFAVVGSDHEYQVNGKRILGRKTKWGTIEVENTTHCEFAYLRDLLIRTHMQNIKDITSNIHFEAYRVKRLNEGNSAMANGIEKEPETQEM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MERDRITA -------CCHHHHHH	9.58	-
12	Phosphorylation	RITALKRSFEVEEIE HHHHHHHCEEEEECC	24.95	24259510
23	Phosphorylation	EEIEPPNSTPPRRVQ EECCCCCCCCCCCCC	48.33	27097102
24	Phosphorylation	EIEPPNSTPPRRVQT ECCCCCCCCCCCCCC	43.91	27097102
31	Phosphorylation	TPPRRVQTPLLRATV CCCCCCCCHHHHHHH	17.04	29779826
37	Phosphorylation	QTPLLRATVASSSQK CCHHHHHHHCCCCHH	15.35	25575281
40	Phosphorylation	LLRATVASSSQKFQD HHHHHHCCCCHHHHH	26.62	23984901
41	Phosphorylation	LRATVASSSQKFQDL HHHHHCCCCHHHHHH	27.35	23984901
42	Phosphorylation	RATVASSSQKFQDLG HHHHCCCCHHHHHHC	34.59	25403869
44	Acetylation	TVASSSQKFQDLGVK HHCCCCHHHHHHCCC	47.11	22902405
62	Phosphorylation	PAARLVDTLSQRSPK HHHHHHHHHHHCCCC	22.34	25403869
64	Phosphorylation	ARLVDTLSQRSPKPS HHHHHHHHHCCCCCC	26.16	27097102
67	Phosphorylation	VDTLSQRSPKPSLRR HHHHHHCCCCCCCCC	29.64	28689409
71	Phosphorylation	SQRSPKPSLRRVDLA HHCCCCCCCCCHHCC	40.40	25403869
90	Phosphorylation	PEPMSRRTELSIDIS CCCCCCCEEEEEECC	39.92	27097102
93	Phosphorylation	MSRRTELSIDISSKQ CCCCEEEEEECCCCC	16.39	27097102
97	Phosphorylation	TELSIDISSKQVEST EEEEEECCCCCCCCC	27.95	30181290
98	Phosphorylation	ELSIDISSKQVESTA EEEEECCCCCCCCCC	27.69	30181290
103	Phosphorylation	ISSKQVESTASTPGP CCCCCCCCCCCCCCC	30.34	23984901
104	Phosphorylation	SSKQVESTASTPGPS CCCCCCCCCCCCCCC	15.89	23984901
106	Phosphorylation	KQVESTASTPGPSRF CCCCCCCCCCCCCHH	34.91	23984901
107	Phosphorylation	QVESTASTPGPSRFG CCCCCCCCCCCCHHC	29.78	22108457
111	Phosphorylation	TASTPGPSRFGLKRA CCCCCCCCHHCCCHH	46.27	23984901
125	Phosphorylation	AEVLGHKTPEPVPRR HHHCCCCCCCCCCCC	27.49	23298284
139	Acetylation	RTEITIVKPQESGLR CCEEEEECCCCCCCC	36.81	22902405
150	Phosphorylation	SGLRRVETPASKAPE CCCCCCCCCHHHCCC	22.69	29779826
153	Phosphorylation	RRVETPASKAPEGSA CCCCCCHHHCCCCCC	30.47	16641100
258	Phosphorylation	KAPVDFGYVGIDSIL CCCCCCCCCCHHHHH	8.76	-
307	Phosphorylation	KSKISRKSVQPISEE HCCCCCCCCCCCCHH	25.52	29779826
312	Phosphorylation	RKSVQPISEERIPKT CCCCCCCCHHHCCCE	39.84	25403869
332	Acetylation	ITHDIEEKGVRMKLT EECCHHHHCCEEEEE	50.33	22902405
332	Ubiquitination	ITHDIEEKGVRMKLT EECCHHHHCCEEEEE	50.33	-
428	Phosphorylation	PVIAKADTLTLEERV HEEEECCCCCHHHHH	26.88	23984901
430	Phosphorylation	IAKADTLTLEERVYF EEECCCCCHHHHHHH	33.93	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEPT9_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEPT9_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEPT9_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SEPT9_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomics of vasopressin-sensitive renal cells:regulation of aquaporin-2 phosphorylation at two sites.";
Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-31 AND THR-150, AND MASSSPECTROMETRY.
PubMed: 16641100