dbPTM

SEPT3_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SEPT3_RAT
UniProt AC	Q9WU34
Protein Name	Neuronal-specific septin-3
Gene Name	3-Sep
Organism	Rattus norvegicus (Rat).
Sequence Length	358
Subcellular Localization	Cytoplasm . Cytoplasm, cytoskeleton. Cell junction, synapse . In cultured hippocampal neurons, predominantly localized to presynaptic terminals.
Protein Description	Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)..
Protein Sequence	MSKGLPEARTDTAMSELVPEPRPKPAVPMKPVSINSNLLGCIGIDTIIEQMRKKTMKTGFDFNIMVVGQSGLGKSTLVNTLFKSQVSRKASSWNREEKIPKTVEIKAIGHVIEEGGVKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNVIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDEDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKRLNDNGGLPPGEGLLGTVLPPVPATPCPTAE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
91	Phosphorylation	SQVSRKASSWNREEK HHHHHHCCCCCCCCC	38.63	10744683
152	Acetylation	YINEQYEKFLKEEVN HHHHHHHHHHHHHHH	51.57	22902405
155	Acetylation	EQYEKFLKEEVNIAR HHHHHHHHHHHHHHH	55.77	22902405
198	Acetylation	EFMKHLSKVVNVIPV HHHHHHHHHHHHHHH	57.47	22902405
226	Ubiquitination	EFKQRVRKELEVNGI HHHHHHHHHHHHCCE	64.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
91	S	Phosphorylation	Kinase	PRKG1	P00516	GPS
91	S	Phosphorylation	Kinase	PKG-FAMILY	-	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
91	S	Phosphorylation		15107017
Phosphorylated by PKG on Ser-91.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SEPT3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SEPT3_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SEPT3_RAT

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphorylation of septin 3 on Ser-91 by cGMP-dependent proteinkinase-I in nerve terminals."; Xue J., Milburn P.J., Hanna B.T., Graham M.E., Rostas J.A.,Robinson P.J.; Biochem. J. 381:753-760(2004). Cited for: PHOSPHORYLATION AT SER-91, AND MUTAGENESIS OF SER-91 AND SER-92.	15107017 [Abstract]