SEM5A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEM5A_RAT
• UniProt AC: D3ZTD8
• Protein Name: Semaphorin-5A {ECO:0000250|UniProtKB:Q13591}
• Gene Name: Sema5a {ECO:0000312|Ensembl:ENSRNOP00000016506}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1074
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Description: Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis..
• Protein Sequence: MKGACILAWLFSSLGVWRLARPETQDPAKCQRAEHPVVSYKEIGPWLREFRAENAVDFSRLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVQWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTIRSLSNLTEIHDQISGMARCPYSPQHNSTALLTASGELYAATAMDFPGRDPAIYRSLGTLPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAISQAFNGPFKYQENSRSAWLPYPNPNPNFQCGTMDQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGRDTLVHIIYLATDYGTIKKVRAPLSQSSGSCLLEEIELFPERKSEPIRSLKILHSQSVLFVGLQEHVVKIPLKRCHFHQTRGACIGAQDPYCGWDAVMKKCTSLEESLSMTQWDQSVPTCPTRNLTVDGSFGPWSPWTPCTHTDGTAVGSCLCRSRSCDSPAPQCGGWQCEGPRMEITNCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHVFWTGWGPWERCTAQCGGGIQARRRTCENGPDCAGCNVEYQPCNTNACPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLPDPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEFQECNILPCPVDGVWSCWSSWSKCSATCGGGHYMRTRSCTNPAPAYGGDICLGLHTEEALCNTQTCPENWSEWSEWSVCDASGTQVRTRQCILLFPVGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNMFHMMAVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVSPAALNSSITNHINKLDKYDSVEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
147	N-linked_Glycosylation	CTIRSLSNLTEIHDQ EEEEHHCCCHHHHHH		-
168	N-linked_Glycosylation	CPYSPQHNSTALLTA CCCCCCCCCCEEEEC		-
227	N-linked_Glycosylation	VSSYDIGNFTYFFFR ECEEECCCCEEEEEC		-
277	N-linked_Glycosylation	TFMKARLNCSRPGEV HHHHHHHCCCCCCCC		-
323	N-linked_Glycosylation	ASAVCVFNLSAISQA HHEEEEEEHHHHHHH		-
367	N-linked_Glycosylation	MDQGLYVNLTERNLQ CCCCEEEECCCCCHH		-
536	N-linked_Glycosylation	VPTCPTRNLTVDGSF CCCCCCCCEEECCCC		-
591	N-linked_Glycosylation	GPRMEITNCSRNGGW CCCEEEEECCCCCCC		-
717	N-linked_Glycosylation	WTPWTPVNISDNGGH CCCCCCEECCCCCCC		-
898	N-linked_Glycosylation	NTQTCPENWSEWSEW CCCCCCCCHHHHCCC		-
933	N-linked_Glycosylation	VGSQCSGNTTESRPC CCCCCCCCCCCCCCC		-
1015	N-linked_Glycosylation	PVSPAALNSSITNHI CCCHHHHCHHHHHHH		-
1027	Ubiquitination	NHINKLDKYDSVEAI HHHHHHCCCCHHHHH		-
1035	Ubiquitination	YDSVEAIKAFNKNNL CCHHHHHHHHHHCCC		-
1039	Ubiquitination	EAIKAFNKNNLILEE HHHHHHHHCCCEECC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEM5A_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEM5A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEM5A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SEM5A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.