SEM4A_HUMAN - dbPTM
SEM4A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SEM4A_HUMAN
UniProt AC Q9H3S1
Protein Name Semaphorin-4A
Gene Name SEMA4A
Organism Homo sapiens (Human).
Sequence Length 761
Subcellular Localization Cell membrane
Single-pass type I membrane protein .
Protein Description Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity)..
Protein Sequence MALPALGLDPWSLLGLFLFQLLQLLLPTTTAGGGGQGPMPRVRYYAGDERRALSFFHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPGQLPFNVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPETNPRPGSCSVGPSSDKALTFMKDHFLMDEQVVGTPLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESCVDCVLARDPHCAWDPESRTCCLLSAPNLNSWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPCPHLSALASYYWSHGPAAVPEASSTVYNGSLLLIVQDGVGGLYQCWATENGFSYPVISYWVDSQDQTLALDPELAGIPREHVKVPLTRVSGGAALAAQQSYWPHFVTVTVLFALVLSGALIILVASPLRALRARGKVQGCETLRPGEKAPLSREQHLQSPKECRTSASDVDADNNCLGTEVA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
44PhosphorylationGPMPRVRYYAGDERR
CCCCCEEEECCCHHH
8.53-
45PhosphorylationPMPRVRYYAGDERRA
CCCCEEEECCCHHHH
8.11-
59UbiquitinationALSFFHQKGLQDFDT
HHHHHHHCCCCCCCE
53.68-
106PhosphorylationNMIPWPASDRKKSEC
HCCCCCCCCCCCCCC
33.5925690035
120N-linked_GlycosylationCAFKKKSNETQCFNF
CCEECCCCCCHHHHH
66.28UniProtKB CARBOHYD
135N-linked_GlycosylationIRVLVSYNVTHLYTC
HHHHHHCCCCEEEEC
25.38UniProtKB CARBOHYD
219UbiquitinationLGSQPVLKTDNFLRW
CCCCCEECCCCHHHH
54.81-
277UbiquitinationKNDVGGEKLLQKKWT
HCCCCCHHHHHHHHH
58.74-
372O-linked_GlycosylationTTYRGPETNPRPGSC
EEECCCCCCCCCCCC
54.37OGP
440PhosphorylationVMYLGTTTGSLHKAV
EEEEECCCCCEEEEH
25.31-
496N-linked_GlycosylationVWRVPRANCSVYESC
EEEECCCCCCEEHHH
21.63UniProtKB CARBOHYD
522PhosphorylationAWDPESRTCCLLSAP
CCCCCCCEEEEEECC
19.4918452278
533PhosphorylationLSAPNLNSWKQDMER
EECCCCHHHHHHHHH
38.5218452278
535UbiquitinationAPNLNSWKQDMERGN
CCCCHHHHHHHHHCC
35.92-
549PhosphorylationNPEWACASGPMSRSL
CCCHHHHCCCCCCCC
43.2318452278
607N-linked_GlycosylationEASSTVYNGSLLLIV
CCCCCEECCEEEEEE
29.28UniProtKB CARBOHYD
662UbiquitinationGIPREHVKVPLTRVS
CCCHHHCCCCCEEEC
39.79-
715UbiquitinationRALRARGKVQGCETL
HHHHHCCCCCCCCCC
26.32-
721PhosphorylationGKVQGCETLRPGEKA
CCCCCCCCCCCCCCC
31.9530108239
727UbiquitinationETLRPGEKAPLSREQ
CCCCCCCCCCCCHHH
62.31-
738PhosphorylationSREQHLQSPKECRTS
CHHHHCCCCHHHCCC
44.2828348404
740UbiquitinationEQHLQSPKECRTSAS
HHHCCCCHHHCCCHH
74.76-
744PhosphorylationQSPKECRTSASDVDA
CCCHHHCCCHHHCCC
40.0628857561
745PhosphorylationSPKECRTSASDVDAD
CCHHHCCCHHHCCCC
13.3628450419
747PhosphorylationKECRTSASDVDADNN
HHHCCCHHHCCCCCC
37.6228450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SEM4A_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SEM4A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SEM4A_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SEM4A_HUMAN !!

Drug and Disease Associations
Kegg Disease
H00481 Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); R
H00527 Retinitis pigmentosa (RP)
OMIM Disease
610282Retinitis pigmentosa 35 (RP35)
610283Cone-rod dystrophy 10 (CORD10)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SEM4A_HUMAN

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Related Literatures of Post-Translational Modification

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