UniProt ID | SEM4A_HUMAN | |
---|---|---|
UniProt AC | Q9H3S1 | |
Protein Name | Semaphorin-4A | |
Gene Name | SEMA4A | |
Organism | Homo sapiens (Human). | |
Sequence Length | 761 | |
Subcellular Localization |
Cell membrane Single-pass type I membrane protein . |
|
Protein Description | Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity).. | |
Protein Sequence | MALPALGLDPWSLLGLFLFQLLQLLLPTTTAGGGGQGPMPRVRYYAGDERRALSFFHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPGQLPFNVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPETNPRPGSCSVGPSSDKALTFMKDHFLMDEQVVGTPLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESCVDCVLARDPHCAWDPESRTCCLLSAPNLNSWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPCPHLSALASYYWSHGPAAVPEASSTVYNGSLLLIVQDGVGGLYQCWATENGFSYPVISYWVDSQDQTLALDPELAGIPREHVKVPLTRVSGGAALAAQQSYWPHFVTVTVLFALVLSGALIILVASPLRALRARGKVQGCETLRPGEKAPLSREQHLQSPKECRTSASDVDADNNCLGTEVA | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
44 | Phosphorylation | GPMPRVRYYAGDERR CCCCCEEEECCCHHH | 8.53 | - | |
45 | Phosphorylation | PMPRVRYYAGDERRA CCCCEEEECCCHHHH | 8.11 | - | |
59 | Ubiquitination | ALSFFHQKGLQDFDT HHHHHHHCCCCCCCE | 53.68 | - | |
106 | Phosphorylation | NMIPWPASDRKKSEC HCCCCCCCCCCCCCC | 33.59 | 25690035 | |
120 | N-linked_Glycosylation | CAFKKKSNETQCFNF CCEECCCCCCHHHHH | 66.28 | UniProtKB CARBOHYD | |
135 | N-linked_Glycosylation | IRVLVSYNVTHLYTC HHHHHHCCCCEEEEC | 25.38 | UniProtKB CARBOHYD | |
219 | Ubiquitination | LGSQPVLKTDNFLRW CCCCCEECCCCHHHH | 54.81 | - | |
277 | Ubiquitination | KNDVGGEKLLQKKWT HCCCCCHHHHHHHHH | 58.74 | - | |
372 | O-linked_Glycosylation | TTYRGPETNPRPGSC EEECCCCCCCCCCCC | 54.37 | OGP | |
440 | Phosphorylation | VMYLGTTTGSLHKAV EEEEECCCCCEEEEH | 25.31 | - | |
496 | N-linked_Glycosylation | VWRVPRANCSVYESC EEEECCCCCCEEHHH | 21.63 | UniProtKB CARBOHYD | |
522 | Phosphorylation | AWDPESRTCCLLSAP CCCCCCCEEEEEECC | 19.49 | 18452278 | |
533 | Phosphorylation | LSAPNLNSWKQDMER EECCCCHHHHHHHHH | 38.52 | 18452278 | |
535 | Ubiquitination | APNLNSWKQDMERGN CCCCHHHHHHHHHCC | 35.92 | - | |
549 | Phosphorylation | NPEWACASGPMSRSL CCCHHHHCCCCCCCC | 43.23 | 18452278 | |
607 | N-linked_Glycosylation | EASSTVYNGSLLLIV CCCCCEECCEEEEEE | 29.28 | UniProtKB CARBOHYD | |
662 | Ubiquitination | GIPREHVKVPLTRVS CCCHHHCCCCCEEEC | 39.79 | - | |
715 | Ubiquitination | RALRARGKVQGCETL HHHHHCCCCCCCCCC | 26.32 | - | |
721 | Phosphorylation | GKVQGCETLRPGEKA CCCCCCCCCCCCCCC | 31.95 | 30108239 | |
727 | Ubiquitination | ETLRPGEKAPLSREQ CCCCCCCCCCCCHHH | 62.31 | - | |
738 | Phosphorylation | SREQHLQSPKECRTS CHHHHCCCCHHHCCC | 44.28 | 28348404 | |
740 | Ubiquitination | EQHLQSPKECRTSAS HHHCCCCHHHCCCHH | 74.76 | - | |
744 | Phosphorylation | QSPKECRTSASDVDA CCCHHHCCCHHHCCC | 40.06 | 28857561 | |
745 | Phosphorylation | SPKECRTSASDVDAD CCHHHCCCHHHCCCC | 13.36 | 28450419 | |
747 | Phosphorylation | KECRTSASDVDADNN HHHCCCHHHCCCCCC | 37.62 | 28450419 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SEM4A_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SEM4A_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SEM4A_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of SEM4A_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
H00481 | Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); R | |||||
H00527 | Retinitis pigmentosa (RP) | |||||
OMIM Disease | ||||||
610282 | Retinitis pigmentosa 35 (RP35) | |||||
610283 | Cone-rod dystrophy 10 (CORD10) | |||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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