UniProt ID | SEM3G_HUMAN | |
---|---|---|
UniProt AC | Q9NS98 | |
Protein Name | Semaphorin-3G | |
Gene Name | SEMA3G | |
Organism | Homo sapiens (Human). | |
Sequence Length | 782 | |
Subcellular Localization | Secreted. | |
Protein Description | Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).. | |
Protein Sequence | MAPSAWAICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFVRVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMAARIPENSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPEEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYCAWDGASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEHNSTFLECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEHGFSQTVVRLALVVIVASQLDNLFPPEPKPEEPPARGGLASTPPKAWYKDILQLIGFANLPRVDEYCERVWCRGTTECSGCFRSRSRGKQARGKSWAGLELGKKMKSRVHAEHNRTPREVEAT | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
4 | Phosphorylation | ----MAPSAWAICWL ----CCCHHHHHHHH | 27.23 | 24043423 | |
44 | N-linked_Glycosylation | YRDLLSANRSAIFLG HHHHHHCCCEEEEEC | 34.75 | UniProtKB CARBOHYD | |
80 | Phosphorylation | GGLDALYSLRLDQAW CCHHHHHHCCCCCCC | 14.09 | 24719451 | |
127 | N-linked_Glycosylation | VRVLQPHNRTHLLAC HHHHCCCCCCCEEEE | 58.17 | UniProtKB CARBOHYD | |
264 | Phosphorylation | GSNHVTVSRVGRVCV CCCCEEEEEECCEEE | 16.34 | 24719451 | |
396 | Phosphorylation | QPGRPFGSTKDYPDE CCCCCCCCCCCCHHH | 32.44 | 22468782 | |
507 | Phosphorylation | SVKRQMLYVGSRLGV EECCHHHHHHCHHHH | 9.45 | - | |
665 | Phosphorylation | LEHGFSQTVVRLALV CCCCCCHHHHHHHHH | 21.55 | 24719451 | |
700 | Phosphorylation | PARGGLASTPPKAWY CCCCCCCCCCCCHHH | 46.63 | 25247763 | |
701 | Phosphorylation | ARGGLASTPPKAWYK CCCCCCCCCCCHHHH | 37.69 | 25247763 | |
707 | Phosphorylation | STPPKAWYKDILQLI CCCCCHHHHHHHHHH | 12.02 | 22817900 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SEM3G_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SEM3G_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SEM3G_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of SEM3G_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-707, AND MASSSPECTROMETRY. |