SEM3G_HUMAN - dbPTM
SEM3G_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SEM3G_HUMAN
UniProt AC Q9NS98
Protein Name Semaphorin-3G
Gene Name SEMA3G
Organism Homo sapiens (Human).
Sequence Length 782
Subcellular Localization Secreted.
Protein Description Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity)..
Protein Sequence MAPSAWAICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFVRVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMAARIPENSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPEEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYCAWDGASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEHNSTFLECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEHGFSQTVVRLALVVIVASQLDNLFPPEPKPEEPPARGGLASTPPKAWYKDILQLIGFANLPRVDEYCERVWCRGTTECSGCFRSRSRGKQARGKSWAGLELGKKMKSRVHAEHNRTPREVEAT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MAPSAWAICWL
----CCCHHHHHHHH
27.2324043423
44N-linked_GlycosylationYRDLLSANRSAIFLG
HHHHHHCCCEEEEEC
34.75UniProtKB CARBOHYD
80PhosphorylationGGLDALYSLRLDQAW
CCHHHHHHCCCCCCC
14.0924719451
127N-linked_GlycosylationVRVLQPHNRTHLLAC
HHHHCCCCCCCEEEE
58.17UniProtKB CARBOHYD
264PhosphorylationGSNHVTVSRVGRVCV
CCCCEEEEEECCEEE
16.3424719451
396PhosphorylationQPGRPFGSTKDYPDE
CCCCCCCCCCCCHHH
32.4422468782
507PhosphorylationSVKRQMLYVGSRLGV
EECCHHHHHHCHHHH
9.45-
665PhosphorylationLEHGFSQTVVRLALV
CCCCCCHHHHHHHHH
21.5524719451
700PhosphorylationPARGGLASTPPKAWY
CCCCCCCCCCCCHHH
46.6325247763
701PhosphorylationARGGLASTPPKAWYK
CCCCCCCCCCCHHHH
37.6925247763
707PhosphorylationSTPPKAWYKDILQLI
CCCCCHHHHHHHHHH
12.0222817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SEM3G_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SEM3G_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SEM3G_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SEM3G_HUMAN !!

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SEM3G_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-707, AND MASSSPECTROMETRY.

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