| UniProt ID | SEM3C_HUMAN | |
|---|---|---|
| UniProt AC | Q99985 | |
| Protein Name | Semaphorin-3C | |
| Gene Name | SEMA3C | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 751 | |
| Subcellular Localization | Secreted. | |
| Protein Description | Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity).. | |
| Protein Sequence | MAFRTICVLVGVFICSICVKGSSQPQARVYLTFDELRETKTSEYFSLSHHPLDYRILLMDEDQDRIYVGSKDHILSLNINNISQEALSVFWPASTIKVEECKMAGKDPTHGCGNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRRSEDQVFMIDSKCESGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYFFFKEKLTDNNRSTKQIHSMIARICPNDTGGLRSLVNKWTTFLKARLVCSVTDEDGPETHFDELEDVFLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLSDIQTVFNGPFAHKEGPNHQLISYQGRIPYPRPGTCPGGAFTPNMRTTKEFPDDVVTFIRNHPLMYNSIYPIHKRPLIVRIGTDYKYTKIAVDRVNAADGRYHVLFLGTDRGTVQKVVVLPTNNSVSGELILEELEVFKNHAPITTMKISSKKQQLYVSSNEGVSQVSLHRCHIYGTACADCCLARDPYCAWDGHSCSRFYPTGKRRSRRQDVRHGNPLTQCRGFNLKAYRNAAEIVQYGVKNNTTFLECAPKSPQASIKWLLQKDKDRRKEVKLNERIIATSQGLLIRSVQGSDQGLYHCIATENSFKQTIAKINFKVLDSEMVAVVTDKWSPWTWASSVRALPFHPKDIMGAFSHSEMQMINQYCKDTRQQHQQGDESQKMRGDYGKLKALINSRKSRNRRNQLPES | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 44 | Phosphorylation | RETKTSEYFSLSHHP HCCCCCCCEECCCCC | 9.76 | - | |
| 67 | Phosphorylation | DEDQDRIYVGSKDHI CCCCCCEEECCCCEE | 10.31 | 20873877 | |
| 70 | Phosphorylation | QDRIYVGSKDHILSL CCCEEECCCCEEEEE | 25.51 | 20873877 | |
| 81 | N-linked_Glycosylation | ILSLNINNISQEALS EEEEECCCCCHHHHH | 31.34 | UniProtKB CARBOHYD | |
| 123 | N-linked_Glycosylation | VRVIQTFNRTHLYVC HHHHHCCCCCEEEEC | 51.86 | UniProtKB CARBOHYD | |
| 194 | Phosphorylation | MYIDFMGTDAAIFRS CEEEECCCHHHHHHH | 15.63 | - | |
| 203 | Phosphorylation | AAIFRSLTKRNAVRT HHHHHHHHHCCCCCC | 29.25 | 21712546 | |
| 252 | N-linked_Glycosylation | KEKLTDNNRSTKQIH EEECCCCCCCHHHHH | 41.93 | UniProtKB CARBOHYD | |
| 268 | N-linked_Glycosylation | MIARICPNDTGGLRS HHHHHCCCCCCHHHH | 55.88 | UniProtKB CARBOHYD | |
| 270 | Phosphorylation | ARICPNDTGGLRSLV HHHCCCCCCHHHHHH | 39.53 | - | |
| 465 | N-linked_Glycosylation | KVVVLPTNNSVSGEL EEEEEECCCCCCCEE | 36.52 | UniProtKB CARBOHYD | |
| 585 | N-linked_Glycosylation | IVQYGVKNNTTFLEC HHHHCCCCCCEEEEC | 48.99 | UniProtKB CARBOHYD | |
| 586 | N-linked_Glycosylation | VQYGVKNNTTFLECA HHHCCCCCCEEEECC | 34.48 | UniProtKB CARBOHYD | |
| 596 | Phosphorylation | FLECAPKSPQASIKW EEECCCCCCCHHHHH | 22.61 | - | |
| 600 | Phosphorylation | APKSPQASIKWLLQK CCCCCCHHHHHHHHC | 21.32 | - | |
| 671 | Phosphorylation | SEMVAVVTDKWSPWT HHEEEEEECCCCCCC | 25.84 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SEM3C_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SEM3C_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SEM3C_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SEM3C_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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