| UniProt ID | SEM3A_HUMAN | |
|---|---|---|
| UniProt AC | Q14563 | |
| Protein Name | Semaphorin-3A | |
| Gene Name | SEMA3A | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 771 | |
| Subcellular Localization | Secreted. | |
| Protein Description | Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.. | |
| Protein Sequence | MGWLTRIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTLEVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRRTHEFERAPRSV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 42 | Phosphorylation | SYKEMLESNNVITFN EHHHHHHHCCEEEEC | 29.73 | - | |
| 53 | N-linked_Glycosylation | ITFNGLANSSSYHTF EEECCCCCCCCCEEE | 47.68 | UniProtKB CARBOHYD | |
| 97 | Phosphorylation | KIVWPVSYTRRDECK HEECCCCCCCHHHCH | 12.42 | 22817900 | |
| 125 | N-linked_Glycosylation | IKVLKAYNQTHLYAC HHHHHHHCCCCEEEC | 45.17 | UniProtKB CARBOHYD | |
| 160 | Phosphorylation | NIFKLENSHFENGRG CCEECCCCCCCCCCC | 21.85 | 27499020 | |
| 405 | Phosphorylation | DVITFARSHPAMYNP CCHHHHHCCCCCCCC | 30.32 | - | |
| 410 | Phosphorylation | ARSHPAMYNPVFPMN HHCCCCCCCCCCCCC | 20.58 | - | |
| 481 | Phosphorylation | EVLLEEMTVFREPTA HHHHHHCCCCCCCCC | 21.55 | 24719451 | |
| 490 | Phosphorylation | FREPTAISAMELSTK CCCCCCCEEEECCCC | 21.06 | 28555341 | |
| 496 | Phosphorylation | ISAMELSTKQQQLYI CEEEECCCCCCEEEC | 45.56 | 28555341 | |
| 590 | N-linked_Glycosylation | RIIYGVENSSTFLEC HEEEEECCCCCEEEE | 38.56 | UniProtKB CARBOHYD | |
| 698 | Phosphorylation | MSNSMTPSQKVWYRD CCCCCCCCHHHHHHH | 33.20 | - | |
| 727 | Ubiquitination | EFCEQVWKRDRKQRR HHHHHHHHHHHHHHH | 45.63 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SEM3A_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SEM3A_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SEM3A_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SEM3A_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 614897 | Hypogonadotropic hypogonadism 16 with or without anosmia (HH16) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
