SEC7A_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEC7A_SCHPO
• UniProt AC: Q9UT02
• Protein Name: Protein transport protein sec71
• Gene Name: sec71
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1811
• Protein Description: May play a role in protein transport..
• Protein Sequence: MTDLEIETVSRVSSNPDEVKGSSVVEEEPDSESTIKSRVSDEIDEHDSIPEQSNTEKSIEINDKNLEAEKDIESNLSLRPPEDDLDSRSIESEQTGTLSKQTTSTSEAPQDLKIWKNISNASNQNSGKLNPQLFVIEAFKHMSKAKATKRHKKLREAINNVQIELQKQPFLLPEVILEPLVMACQTNSTTLLTITLDCFAKLIDYNYFDSPTLNPSDITLMERVVNTIASCFCGESTPERVQLQIVKALLAAITSERTIIRHSFLLTAVRQTYNIFLLCKDSTTQAIAQVALLQMVDSVFQRLSTVLNHEREFSTINMNKSSSNGTPDRANSPIPSQLSENKLTLESFEHRKSFDQVREEAPLEEDSLEQQLLRDAFLLIRALCKLSIKNIPYEHEYDLKSQSMRSKLMSLHLIYHILRTYMNILSDINVKIRSPTSTPTPLIDAVKQYICLALAKNVVSHVLPVFEISCEIFWLILSELKNFFKSELEVFFTEIFFPILEMRTSSNQQKIVLLNIFHRMCEEPQTLIELYLNYDCISGNTENIYERAIVTLSRIASQSTSDPPPSFVFRDDQLVIDKPGFVYHTLNDIPQLNSSTIGSYVHSHNPPYFDYQIRLKSYRCLISTLSSLFTWCNQTFAPTVEITAKDDETESTSKGEEPQKSKSEPPSAGINSTSMDNLESSGQALATDDPSQFENLKHRKKQLQEAIQKFNYKPKEGIKILLSSHFIASKTPTDIAKFLISTEGLDKAVLGEYLGEGNDENIAIMHSFVDHMSFNDIPFVNALRSFLQKFRLPGEAQKIDRFMLKFAEKYIDDNLGVFKNADTAYILAYSIIMLNTDLHSPQVKNRMTCQDFIKNNRGVDDGANLSDSFLTEVYEEIQKNEIVLKDEQDPTSNFPEIPGTSNLSFAANISNALATVGRDLQREAYYMASNKMANKTEALFKDLIREQRERGKLSGNDIYYTARHFEHVCPMFEAVWMPILAAFSEPLQLSSDPALIQLSLDGFRLAMNVIFFFSMDLPRNAFMQTLTKFTHLNNTSELKWTNMHALKTLLEISLAHGDKLRDSWKDVLLCISQLERVQLISAGVDINSLPDVSTTKPLRKSLDKNIRQSRSGSISLKHSKSFQSASTHSTKSSSVEIVREYSSREVVMAVDMLFSNTRNLGSEGIYDFVKALIEVSWEEIECSLELSNPRLFSLQKLVEISYYNMRRIRMEWSSIWSLLGTYFTQVSCHENSIIASFALDSLRQFSMQFLEIEELSHFKFQKDFLQPFSHAMENSQDLKIKDLVLRCIDQMIKARYQNIRSGWRTIFHILAYASKIENLLVLQCAISVVSSLGHEHISCVLTQGAYIDLISCITKFAKLNGNQKFCLSCVDMLKNLEHELIKHLKHMKKESVYSKKLEEEYWLPFLLSFNEIICEASDLEVRSKALKVLFDCLYRHADDFDEEFWETVSNKALLSIFSILSITNSQRLYLAKNTEETEVWMLTTMVEALKAFIELIKNLFERLHFLLPKALNLLEKCICQENSMISKVGLSCFSQFVLKNKNQFKDVDWDEIINSINQLLQMTLPIELRDPSLYPQVNSDSSLEDVKENSFRPHEISRFNSQSVFKSKKHHLKSIVVKCTLQLLMLNCLWELFHSDNMLTNIPKRKMVKLLDILKQSWEFAESFNSDFEIRAKILSSGIVEHMPNLLSQEALCAKLYFYTAFECMSSLKSDSHDTEEYNDLMDVFQKKIYLASQLVLHGFQRVIGDNPVKGVAAFQPVIAALVSYINSLDEIQFSRGKSEFYQLLCAIVACGHIDQQLGTSLSNAFLRYAC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MTDLEIETVSRVSSN CCCCEEEEEEECCCC	29.46	21712547
10	Phosphorylation	DLEIETVSRVSSNPD CCEEEEEEECCCCCC	34.09	24763107
13	Phosphorylation	IETVSRVSSNPDEVK EEEEEECCCCCCCCC	24.24	24763107
14	Phosphorylation	ETVSRVSSNPDEVKG EEEEECCCCCCCCCC	49.91	24763107
22	Phosphorylation	NPDEVKGSSVVEEEP CCCCCCCCCCCCCCC	17.78	24763107
23	Phosphorylation	PDEVKGSSVVEEEPD CCCCCCCCCCCCCCC	38.56	29996109
31	Phosphorylation	VVEEEPDSESTIKSR CCCCCCCCCCHHHHH	44.13	28889911
33	Phosphorylation	EEEPDSESTIKSRVS CCCCCCCCHHHHHCC	39.11	21712547
37	Phosphorylation	DSESTIKSRVSDEID CCCCHHHHHCCCCCC	33.78	29996109
40	Phosphorylation	STIKSRVSDEIDEHD CHHHHHCCCCCCCCC	28.54	28889911
48	Phosphorylation	DEIDEHDSIPEQSNT CCCCCCCCCCCCCCC	41.78	24763107
53	Phosphorylation	HDSIPEQSNTEKSIE CCCCCCCCCCCCEEE	44.02	29996109
55	Phosphorylation	SIPEQSNTEKSIEIN CCCCCCCCCCEEEEC	50.46	29996109
58	Phosphorylation	EQSNTEKSIEINDKN CCCCCCCEEEECCCC	21.15	21712547
87	Phosphorylation	PPEDDLDSRSIESEQ CCCCCCCCCCCCCCC	34.91	21712547
89	Phosphorylation	EDDLDSRSIESEQTG CCCCCCCCCCCCCCC	34.36	25720772
92	Phosphorylation	LDSRSIESEQTGTLS CCCCCCCCCCCCCCC	33.08	25720772
95	Phosphorylation	RSIESEQTGTLSKQT CCCCCCCCCCCCCCC	28.25	21712547
99	Phosphorylation	SEQTGTLSKQTTSTS CCCCCCCCCCCCCCC	23.66	29996109
103	Phosphorylation	GTLSKQTTSTSEAPQ CCCCCCCCCCCCCCC	27.75	25720772
104	Phosphorylation	TLSKQTTSTSEAPQD CCCCCCCCCCCCCCC	33.07	25720772
105	Phosphorylation	LSKQTTSTSEAPQDL CCCCCCCCCCCCCCH	28.61	25720772
106	Phosphorylation	SKQTTSTSEAPQDLK CCCCCCCCCCCCCHH	31.37	25720772
119	Phosphorylation	LKIWKNISNASNQNS HHHHHHHHCCCCCCC	35.42	25720772
122	Phosphorylation	WKNISNASNQNSGKL HHHHHCCCCCCCCCC	43.10	25720772
321	Phosphorylation	STINMNKSSSNGTPD EEEECCCCCCCCCCC	33.71	21712547
322	Phosphorylation	TINMNKSSSNGTPDR EEECCCCCCCCCCCC	29.45	21712547
323	Phosphorylation	INMNKSSSNGTPDRA EECCCCCCCCCCCCC	46.50	28889911
326	Phosphorylation	NKSSSNGTPDRANSP CCCCCCCCCCCCCCC	26.68	28889911
332	Phosphorylation	GTPDRANSPIPSQLS CCCCCCCCCCCCCCC	24.19	28889911
336	Phosphorylation	RANSPIPSQLSENKL CCCCCCCCCCCCCCC	44.46	29996109
353	Phosphorylation	ESFEHRKSFDQVREE HHHHHHHCHHHHHHH	33.73	28889911
649	Phosphorylation	ITAKDDETESTSKGE EEECCCCCCCCCCCC	42.08	25720772
651	Phosphorylation	AKDDETESTSKGEEP ECCCCCCCCCCCCCC	45.46	25720772
652	Phosphorylation	KDDETESTSKGEEPQ CCCCCCCCCCCCCCC	28.38	24763107
672	Phosphorylation	PPSAGINSTSMDNLE CCCCCCCCCCCCCHH	21.68	27738172
741	Phosphorylation	DIAKFLISTEGLDKA HHHHHHHCCCCCCHH	23.66	28889911
742	Phosphorylation	IAKFLISTEGLDKAV HHHHHHCCCCCCHHH	27.38	28889911
1101	Phosphorylation	TTKPLRKSLDKNIRQ CCHHHHHHHHHCHHH	35.05	29996109
1113	Phosphorylation	IRQSRSGSISLKHSK HHHHCCCCEEECCCC	15.39	28889911
1115	Phosphorylation	QSRSGSISLKHSKSF HHCCCCEEECCCCCC	32.82	21712547
1121	Phosphorylation	ISLKHSKSFQSASTH EEECCCCCCCCCCCC	31.37	24763107
1134	Phosphorylation	THSTKSSSVEIVREY CCCCCCCCCHHHHHC	30.75	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEC7A_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEC7A_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEC7A_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of SEC7A_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40; THR-326; SER-332;SER-353; SER-741 AND THR-742, AND MASS SPECTROMETRY.
PubMed: 18257517